New depression pill shows promise in early trial

NCT ID NCT06280235

Completed Symptom relief Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called BI 1569912 in 243 adults aged 18–65 with major depression that didn't improve with previous treatments. Participants took either a low, medium, or high dose of the drug or a placebo once daily for 6 weeks, while continuing their usual depression therapy. Researchers measured changes in depression symptoms using a standard rating scale to see if the drug helps more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 1569912
What this could lead to: If it works, this could offer a new add-on option for people with depression that hasn't improved with standard treatments.
What could go wrong: This is an early Phase 2 trial with only 243 participants over 6 weeks, so results may not apply to everyone. The drug may not outperform placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE DISORDER, MAJOR

Contacts and locations

Locations

A-SHINE s.r.o

Pilsen, 30100, Czechia
ActivMed Practices & Research

Methuen, Massachusetts, 01844, United States
Adams Clinical

Watertown, Massachusetts, 02472, United States
Aisakura Clinic

Fukuoka, 810-0001, Japan
Ambulatory for Individual Practice for Specialized Medical Care in Psychiatry - Dr Ivo Natsov

Cherven Bryag, 5980, Bulgaria
Anima Research Center

Alken, 3570, Belgium
Asclepes Research Centers-Panorama City-62905

Panorama City, California, 91402, United States
Beijing Anding Hospital

Beijing, 100088, China
Boston Clinical Trials

Roslindale, Massachusetts, 02135, United States
CCM Clinical Research Group, LLC-Miami-68482

Miami, Florida, 33133, United States
CT Clinical Research

Cromwell, Connecticut, 06416, United States
Charité - Universitätsmedizin Berlin

Berlin, 10117, Germany
Chicago Research Center, Incorporated

Chicago, Illinois, 60634, United States
Clintrial s.r.o.

Prague, 100 00, Czechia
DCC "Sv. Vrach and Sv. Sv. Kuzma and Damyan" OOD

Sofia, 1408, Bulgaria
DCC Mladost-M Varna OOD

Varna, 9020, Bulgaria
Excell Research Inc.

Oceanside, California, 92056, United States
Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan
Galiz Research

Hialeah, Florida, 33016, United States
Grayline Research Center

Wichita Falls, Texas, 76309, United States
Hassman Research Institute-Marlton-66897

Marlton, New Jersey, 08053, United States
Hebei Mental Health Center

Baoding, 71000, China
Hirota Clinic

Kurume-shi, 830-0033, Japan
Houston Clinical Trials, LLC

Bellaire, Texas, 77401, United States
Iwaki Clinic, Tokushima, Psychosomatic Medicine

Anan-shi, 774-0014, Japan
Kaku Mental Clinic

Fukuoka, 810-0022, Japan
Kuramitsu Hospital

Fukuoka, 819-0037, Japan
Kyorin University Hospital

Mitaka-shi, 181-8611, Japan
MHC - Ruse, EOOD

Rousse, 7003, Bulgaria
Maynds Tower Mental Clinic

Shibuya-ku, 151-0053, Japan
Medical Center "Sv.Naum"

Sofia, 1113, Bulgaria
Medical Center Hera EOOD

Sofia, 1510, Bulgaria
Medical Center Intermedica Ltd.

Sofia, 1680, Bulgaria
Mental Clinic Sakurazaka

Fukuoka, 810-0023, Japan
Midwest Clinical Research

Dayton, Ohio, 45417, United States
NRC Research Institute

Orange, California, 92868, United States
Neuro-Behavioral Clinical Research

North Canton, Ohio, 44720, United States
Neurobehavioral Research, Inc.

Cedarhurst, New York, 11516, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Peking University Sixth Hospital

Beijing, 100191, China
Premier Clinical Research Institute

Miami, Florida, 33122, United States
Rainbow and Sea Hospital

Karatsu-shi, 847-0031, Japan
Shanghai Mental Health Center

Shanghai, 200030, China
Shenzhen Kangning Hospital

Shenzhen, 518003, China
Somni Bene - Institut für Medizinische Forschung & Schlafmedizin Schwerin GmbH

Schwerin, 19053, Germany
Sooner Clinical Research

Oklahoma City, Oklahoma, 73112, United States
Southwest Biomedical Research, LLC

Tucson, Arizona, 85712, United States
The First Hospital of Hebei Medical University

Shijiazhuang, 50030, China
The Second Xiangya Hospital Of Central South University

Changsha, 410011, China
Tianjin Anding Hospital

Tianjin, 300222, China
Universitair Psychiatrisch Centrum Duffel (UPC Duffel)

Duffel, 2570, Belgium
iResearch Atlanta

Decatur, Georgia, 30030, United States

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