Can cannabis oil help you sleep when You're depressed?

NCT ID NCT05041647

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larger study is possible, and to check for any sleep improvements and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cannabis oil (CBD/THC combination)

What this could lead to

If it works, this could point toward a new option for improving sleep in people with depression.

What could go wrong

This was a very small pilot study with only 14 participants, so results may not apply widely. The study focused on feasibility, not proof of effectiveness.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cannabis dependence Depression depressive disorder insomnia major depressive disorder Psychological Well-Being sleep disorder sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L9C 0E3, Canada