Could an arthritis drug lift depression in certain patients?

This study tests whether adding the anti-inflammatory drug celecoxib to standard depression treatment can improve symptoms in people with a specific subtype called immuno-metabolic depression (IMD). IMD is marked by symptoms like increased appetite, weight gain, and fatigue, along with signs of inflammation. The trial involves 140 adults with moderate to severe depression and elevated inflammation markers, comparing celecoxib to a placebo over 12 weeks.