Could a stress hormone be behind the hidden danger of low blood sugar?
NCT ID NCT06422494
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to see if this reduces the immune response. The goal is to understand if this immune reaction contributes to the higher risk of heart disease seen in people with type 1 diabetes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Insulin and glucose infusion to induce low blood sugar, plus phentolamine and propranolol to block adrenaline receptors
- What this could lead to
- If blocking adrenaline reduces the immune reaction during low blood sugar, it could point toward ways to lower the risk of heart problems in people with type 1 diabetes.
- What could go wrong
- This is a small, early-stage study in a controlled lab setting, so results may not apply to real-life situations. Blocking adrenaline could also have side effects, like changes in heart rate or blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Radboud University Medical Center, Nijmegen, Netherlands
Nijmegen, Gelderland, 6525 GA, Netherlands
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