DIABETES MELLITUS, TYPE 1

This study is testing a potential cure for children with a rare, severe form of type 1 diabetes caused by an immune system defect. Doctors will first give children a transplant of umbilical cord blood stem cells to fix their immune system. If that works, they will then receive a …

This is an early-stage study to check the safety and side effects of a new drug called LY4057996 in healthy volunteers and people with Type 1 or Type 2 diabetes. Researchers will give the drug as an injection under the skin or into a vein and measure how the body processes it. Th…

This study aims to see if helping lower-income families overcome insurance and access barriers to get advanced diabetes technology improves blood sugar control in children with type 1 diabetes. It will enroll 50 children and adolescents from diverse racial/ethnic backgrounds who …

This study is testing if two slightly modified versions of an existing insulin pump set can safely last for up to 7 days at home. Twenty adults with type 1 diabetes will try each set for several weeks. The main goal is to see if the sets can survive the full week without causing …

This study is testing whether transplanting insulin-producing cells, called islets, from deceased donors is safe for people with type 1 diabetes who have already had a kidney transplant. The goal is to see if this procedure can help patients achieve better blood sugar control wit…

This study is testing how well and how safely an automated insulin delivery system works for adults with type 1 diabetes in everyday life. The system is a patch pump that uses an algorithm to automatically adjust insulin doses. Researchers will follow 200 participants for 24 week…

This study is testing whether a new once-weekly insulin injection works as well as the current standard daily insulin injection for controlling blood sugar in adults with type 1 diabetes. About 877 participants will use either the weekly insulin (icodec) or daily insulin (glargin…

This early-stage study is testing a new type of insulin (NNC0363-1063) to see how it interacts with a common non-glucose carbohydrate used in foods and drinks. It involves 36 adults with type 1 diabetes and will check if taking them together is safe and how the body processes the…

This pilot study aims to test if a hybrid closed-loop insulin pump system can help adults with poorly controlled Type 1 diabetes. It will enroll 40 diverse participants from Los Angeles who are not currently using an insulin pump. The main goal is to see if a larger trial is feas…

This study is testing a virtual peer support program designed to help Latinx teenagers with type 1 diabetes use helpful devices like insulin pumps and glucose monitors more often and confidently. The program, called DREAM, was created with input from families and healthcare teams…

This study tests whether providing meals and education after a hospital stay helps people with diabetes who struggle to afford enough food. Researchers will enroll 160 hospitalized patients with diabetes and food insecurity. Some will receive 90 days of meal delivery and nutritio…

This early-stage study is testing an experimental cell therapy called CELZ-201 in adults recently diagnosed with Type 1 Diabetes. The main goal is to see if the treatment is safe and if it can help the body produce its own insulin, potentially reducing the need for insulin inject…

This study is testing whether a very-low-carbohydrate ketogenic diet can help adults with type 1 diabetes better control their blood sugar levels. For 12 weeks, participants will follow either the ketogenic diet or a standard diabetes diet to compare safety and effectiveness. Res…

This study is testing whether using an automated insulin pump system or a special education program can help adults with type 1 diabetes regain their natural ability to feel the symptoms of dangerously low blood sugar (hypoglycemia). About 324 participants who have lost this warn…

This study aims to find the best time to exercise for people with type 1 diabetes. It will compare doing aerobic exercise before breakfast versus after breakfast over 12 weeks. Researchers want to see if exercising on an empty stomach helps control blood sugar better and reduces …

This clinical trial is testing an experimental cell therapy called VX-880 for adults with Type 1 diabetes who experience dangerous low blood sugar episodes. The treatment involves infusing specially engineered cells that may help the body produce its own insulin again. Researcher…

This study is testing whether giving the BCG vaccine (typically used against tuberculosis) multiple times can help children aged 8-18 who already have type 1 diabetes. Researchers want to see if the vaccine can improve long-term blood sugar control and reduce insulin needs over f…

This study is testing whether a medication called baricitinib can help preserve the body's own insulin-producing cells in people recently diagnosed with type 1 diabetes. The trial will involve 300 participants aged 1 to 36 years who were diagnosed within the last 100 days. Partic…

This study is monitoring the safety and real-world performance of Awiqli, a once-weekly insulin, in people with diabetes in Japan. About 630 participants who are already prescribed this medication by their doctor will be observed for one year. Researchers will track side effects,…

This study is testing whether adding a hormone called gastrin to an islet cell transplant can help people with difficult-to-control type 1 diabetes. Islet cells from a donor pancreas are transplanted to help the body make insulin again. Researchers hope gastrin injections will he…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This early-stage study is testing if two modified insulin formulas work faster than a standard one. It involves 20 adults with type 1 diabetes who use insulin pumps. Researchers will give participants different insulin shots and take frequent blood samples to see which one starts…

This is an early safety study testing a new islet cell injection called RGB-5088 for adults with Type 1 diabetes. The main goal is to see if the treatment is safe and if it can help patients achieve better blood sugar control without severe low blood sugar events. Researchers wil…

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This study aims to see if using inhaled insulin for a meal is safer and works better than insulin delivered through a pump when people with type 1 diabetes exercise after eating. It will enroll about 30 adults who use a specific automated insulin pump system. Participants will co…

This study is testing whether a pill called sotagliflozin can slow down kidney damage in 150 people who have both type 1 diabetes and moderate to severe kidney disease. Participants will take either the real pill or a placebo (inactive pill) daily for three years, while following…

This is an early-stage study to check the safety and basic effects of a new drug called NNC0363-1063 for type 1 diabetes. It will involve 154 healthy volunteers and people with type 1 diabetes to see how the body processes the drug and how it impacts blood sugar levels after meal…

This study is testing the safety of transplanting insulin-producing cells into adults with severe, hard-to-control Type 1 diabetes. The goal is to help the body better manage blood sugar levels and reduce dangerous episodes of very low blood sugar. Researchers are giving cells fr…

This study is testing whether the medication semaglutide can improve heart and kidney health in adults with type 1 diabetes. Researchers want to see if it reduces artery stiffness and improves how the body uses insulin, similar to benefits seen in type 2 diabetes. The trial will …

This study is observing how well a new weekly insulin injection, called insulin icodec, controls blood sugar in real-world settings for adults with type 1 diabetes. It will follow 245 participants for about 6-7 months to see if the weekly shot improves blood sugar levels, makes t…

This study aims to see if automated insulin pump systems work well and are safe for adults with type 1 diabetes from underserved communities, who often have worse health outcomes. Researchers will compare three different FDA-approved pump systems against standard insulin injectio…

This study compares two common laser treatment schedules for a serious diabetic eye complication that can cause blindness. Researchers want to see if getting all the laser treatment in one session is as safe and effective as spreading it over several visits. They're enrolling 40 …

This study is testing if adding an investigational oral drug called cadisegliatin to standard insulin therapy can help adults with Type 1 diabetes. The main goal is to see if it reduces the number of serious low blood sugar events over 26 weeks. Researchers will compare the drug'…

This study aims to see if a computer analysis of regular pregnancy ultrasound pictures can detect a condition called fetal hyperinsulinemia, which is high insulin in babies of mothers with type 1 diabetes. Researchers will compare ultrasound images from 20 pregnant women with typ…

This study is testing whether the drug baricitinib can delay or prevent the onset of type 1 diabetes in people who are at high risk. It will involve about 150 children and young adults (ages 1 to under 36) who show early signs of the disease but do not yet need insulin. Participa…

This study is testing whether an experimental drug called Diamyd, injected directly into a lymph node, is safe and can prevent or delay the onset of type 1 diabetes. It involves 16 children and teenagers (ages 8-18) who have specific genetic and immune markers putting them at hig…

This study is testing whether a new cell-based therapy, with or without an antibody drug, can safely delay or prevent the onset of type 1 diabetes in children who are at high risk. About 150 children, aged 6 to 16, who have early signs of the disease but no symptoms, will be rand…

This large study is testing whether giving a COVID-19 vaccine to infants with a high genetic risk for type 1 diabetes can prevent the disease from developing. Over 2,200 children, aged 6 months to 7 months at the start, will receive either the real vaccine or a placebo. Researche…

This study is testing whether a virtual sleep therapy program can help people with type 1 diabetes who also have insomnia. Researchers want to see if improving sleep leads to better blood sugar control and quality of life. They will compare 15 participants receiving sleep therapy…

This study is testing if watching a short animated film and reading a storybook can help reduce fear and anxiety in children who have just been diagnosed with type 1 diabetes. It will involve 64 children aged 7 to 12. One group will watch the film and read the book, while another…

This study is testing two different online group therapy programs to help reduce the emotional distress that often comes with managing type 1 diabetes. Researchers will enroll 200 adults with type 1 diabetes who report significant distress. If the initial group program doesn't wo…

This study aims to understand the step-by-step process that leads to type 1 diabetes. Researchers will follow 4,000 participants, including families affected by the disease and healthy volunteers, for up to 10 years. They will collect blood samples and health information to learn…

This study aims to understand how menstrual cycles affect insulin needs and blood sugar levels in women with type 1 diabetes. Researchers will collect detailed data from 350 participants over several months to identify common patterns. The goal is to gather knowledge that could o…

This study aims to understand how a woman's natural menstrual cycle affects her blood sugar levels and energy use when she has type 1 diabetes. Researchers will closely monitor 40 women using automated insulin delivery systems to see how hormone changes during their cycle impact …