DIABETES MELLITUS TYPE 1

This study tests a new pill called cadisegliatin taken alongside insulin in adults with type 1 diabetes. The goal is to see if it can lower the number of dangerously low blood sugar events (severe hypoglycemia) and improve overall blood sugar control. About 150 participants will …

This study tests whether transplanting insulin-producing cells from deceased donors can help people with brittle type 1 diabetes control blood sugar without insulin shots. Up to 20 adults aged 18-70 will receive the cells through a vein. The main goal is to see if this approach i…

This study is testing a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger pricks. The study will include 80 adults with type 1 or type 2 diabetes to see how accurate and safe the new system is compared to…

This study follows about 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly insulin. Researchers will track side effects and blood sugar control over one year. The goal is to see how well the drug works in everyday medical practice, not to c…

This study tests whether semaglutide, a drug already used for type 2 diabetes, can improve heart and kidney function in adults with type 1 diabetes. Researchers will measure artery stiffness, insulin sensitivity, and kidney blood flow in 60 participants over the course of the tri…

This study tests whether a very-low-carbohydrate (ketogenic) diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will compare the diet to usual care in 58 participants, measuring time in target blood sugar range and insulin sensitivity. The goa…

This early-stage study tests a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The goal is to see if it is safe and can help preserve the body's ability to make some insulin. The study involves 18 adults aged 18 to 35 who have had diabetes for le…

This study tests whether giving repeated doses of the BCG vaccine (traditionally used for tuberculosis) can improve blood sugar control in children aged 8 to 17 with type 1 diabetes. Researchers will measure changes in HbA1c, insulin use, and blood sugar swings over time. The goa…

This study tests if a new insulin taken once a week (insulin icodec) controls blood sugar as well as a standard daily insulin (insulin glargine) in adults with type 1 diabetes. About 877 participants will use either weekly or daily insulin, plus rapid-acting insulin at meals, for…

This study tests new versions of an insulin pump set that can be worn longer, up to 7 days, for people with type 1 diabetes. About 20 adults who already use a Tandem pump and Dexcom CGM will try the new set at home. The goal is to see if the set works safely for a full week witho…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study compares having one laser treatment session versus several sessions for people with proliferative diabetic retinopathy, a serious eye condition that can lead to blindness. Researchers want to see which approach is safer and works better. About 40 adults with diabetes a…

This study tests a treatment called VX-880 for people with type 1 diabetes who have severe low blood sugar episodes. The therapy uses special cells that can make insulin, aiming to reduce or eliminate the need for insulin injections. About 52 adults will receive the treatment and…

This study looks at how well a new insulin called insulin icodec controls blood sugar in people with type 1 diabetes who have never used it before. About 245 participants will take the insulin as prescribed by their doctor for 22 to 30 weeks. Researchers will track changes in blo…

This study tests whether a combination of special immune cells (Tregs) and an antibody drug (rituximab) can delay or prevent type 1 diabetes in children aged 6-16 who are at high risk but still produce insulin normally. About 150 participants will be randomly assigned to one of f…

This study tests whether baricitinib, a drug used for arthritis, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to 35) will receive either baricitinib or a placebo for 60 weeks. The …

This study follows 350 people with type 1 diabetes in France who use the Control-IQ system, a smart insulin pump that automatically adjusts insulin. The goal is to see how safe and effective the system is in everyday life, focusing on preventing dangerous blood sugar events and i…

This early-stage trial tests a new islet cell injection (RGB-5088) in 10 adults with type 1 diabetes who have severe low blood sugar episodes. The goal is to see if the treatment is safe and can help control blood sugar without insulin. Participants will be monitored for side eff…

This study tests whether an online training and peer support platform (Support-t) helps teenagers with type 1 diabetes prepare for moving from pediatric to adult healthcare. About 200 teens aged 14-16 from four Quebec hospitals will either receive usual care or also get access to…

This study tests whether the drug sotagliflozin can slow kidney function loss in 150 people with type 1 diabetes and moderate to severe kidney disease. Participants will take either the drug or a placebo daily for 3 years, while following a plan to prevent a serious side effect c…

This study is for children with a rare form of type 1 diabetes that also involves a weak immune system. Doctors first transplant umbilical cord blood stem cells to rebuild the immune system, then transplant islet cells to help the body make insulin again. The goal is to see if th…

This study enrolls 50 children and teens (ages 6 to under 18) with type 1 diabetes who have high blood sugar levels and come from low-income families. Participants will receive help getting approved for advanced insulin pumps and continuous glucose monitors, with an insurance nav…

This study tests whether automated insulin pumps (hybrid closed loop systems) can improve blood sugar control in underserved adults with type 1 diabetes, who often have worse outcomes. About 140 participants will be randomly assigned to use one of three FDA-approved pumps or stan…

This study tests whether strictly avoiding low blood sugar (hypoglycemia) can help adults with type 1 diabetes regain the ability to feel warning symptoms. About 324 participants with impaired awareness of hypoglycemia will use a closed-loop insulin system and education. The goal…

This study tests whether adding a natural gut hormone called gastrin to islet cell transplants can help people with hard-to-control type 1 diabetes produce their own insulin and improve blood sugar. About 20 adults aged 18-68 with unstable blood sugar will receive donor islet cel…

This study looks at whether giving hospitalized diabetes patients who struggle to afford food access to free meals and nutrition education can reduce food insecurity and improve health. About 160 adults with type 1 or type 2 diabetes will be randomly assigned to receive either st…

This study looks at whether doing aerobic exercise before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Twenty adults with type 1 diabetes will train for 12 weeks. Researchers will track insulin use and blood sugar levels to find the best …

This study looks at whether inhaled insulin (Afrezza) is safer than standard pump insulin for preventing low blood sugar during exercise after a meal in adults with type 1 diabetes. About 30 people aged 18-65 who use a Tandem insulin pump with Control-IQ will complete three exerc…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already had a kidney transplant. The goal is to achieve better blood sugar control without needing insulin shots. Ten participants aged 18 to 68…

This study tests whether a hybrid closed-loop insulin pump can help adults with poorly controlled type 1 diabetes (A1c >8.5%) manage their condition more easily. The trial focuses on diverse patients from Los Angeles who are not currently using an insulin pump. Researchers want t…

This study tests a new automated insulin delivery system (the Medtrum TouchCare Nano with APGO algorithm) in 200 adults with type 1 diabetes. The system uses a patch pump to automatically adjust insulin based on blood sugar levels. Researchers will measure changes in blood sugar …

This study tests whether giving the COVID-19 vaccine to babies as young as 6 months old can lower their chance of developing type 1 diabetes. About 2,252 children with a high genetic risk for the disease will be randomly assigned to receive either the vaccine or a placebo. Resear…

This study tests whether baricitinib, an oral drug, can delay the start of type 1 diabetes in children aged 1 to 36 months who are at high risk. About 150 participants will receive either baricitinib or a placebo for up to 5 years. The main goal is to see if the drug can push bac…

This early-phase study tests a new drug called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the drug moves through the body and its effe…

This study tests a group-based psychological program called ACTnow for young adults (18-35) with type 1 diabetes who feel overwhelmed by their condition. The program includes six bi-weekly sessions with a psychologist and nurse, focusing on mindfulness and coping skills. Research…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve may get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a type of talk therapy for insomnia (CBTi) can help people with type 1 diabetes sleep better and control their blood sugar. About 15 adults with type 1 diabetes and poor sleep will either get 8 virtual therapy sessions or health education emails. Research…

This study looks at whether watching animated films or reading storybooks can lower fear and anxiety in children ages 7 to 12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and researchers will measure their anxiety and fear levels using spec…

This study looks at whether ultrasound images of the fetal liver can show signs of high insulin levels in babies of mothers with type 1 diabetes. Researchers will compare these images between 60 pregnant women with diabetes and healthy controls. The goal is to find a noninvasive …

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. Researchers will track 40 women over their cycles using a closed-loop insulin system. The goal is to understand when insulin needs change and how hormones affect glucose …

This study aims to understand how insulin sensitivity and blood sugar levels change across menstrual cycles in women with type 1 diabetes. Researchers will track 350 women aged 18-40 who use automated insulin delivery systems. The goal is to identify patterns that could help pers…

This study aims to learn the step-by-step process that causes type 1 diabetes. Researchers believe a person's immune system, guided by genes and environment, plays a key role. Participants include families with a history of type 1 diabetes and healthy controls. They provide a blo…

This early-stage study is testing a new insulin called NNC0363-1063 in 36 adults with type 1 diabetes. Researchers want to see how this insulin interacts with a non-glucose carbohydrate found in foods and drinks, and whether taking them together is safe. Participants will receive…

This study tests two experimental insulin formulas to see if they work faster than a standard insulin in adults with type 1 diabetes. Twenty participants will receive each insulin during three separate visits, and blood samples will track how quickly the insulin enters the bloods…