DIABETES MELLITUS TYPE 1

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The goal is to see if sharing continuous glucose monitor data helps improve blood sugar levels and reduce diabetes-related stress. About 168 participants will be followe…

This study tests whether using a continuous glucose monitor (CGM) with the help of a Patient Navigator can improve diabetes management and quality of life for people with type 1 diabetes. The study includes 150 participants aged 14 to 64 who have had serious diabetes complication…

This study tests a family-based weight management program for youth with type 1 diabetes (ages 6-17) who are overweight or obese, along with one parent who is also overweight. The program adapts a proven treatment for home delivery, aiming to improve weight, blood sugar control, …

This study tests whether dulaglutide, a drug used in type 2 diabetes, can improve the function of small blood vessels in adults with type 1 diabetes. The goal is to see if it reduces oxidative stress and helps blood flow better in muscles. The trial was suspended and aimed to enr…

This early-stage study tests a new drug, NNC0194-0499, in 96 adults with type 1 diabetes. The goal is to see if adding this drug, alone or with semaglutide, helps keep blood sugar in a healthy range better than placebo. All participants continue their usual insulin. The study las…

This early-stage study tests whether a device called ENC-201-CED can safely hold insulin-producing cells under the skin in people with type 1 diabetes. Ten participants who already qualify for standard islet transplants will receive the device. The main goal is to check for side …

This study planned to test a combination of four drugs (ATG, low-dose IL-2, adalimumab, and exenatide) in people aged 18-35 newly diagnosed with type 1 diabetes. The goal was to see if the treatment could help the body keep making its own insulin and improve immune regulation. Ho…

This early-stage study tests whether infusions of stem cells from donated umbilical cords are safe and can help preserve the body's ability to make insulin in people recently diagnosed with type 1 diabetes. The trial involves 60 adults aged 18 to 40 who were diagnosed within the …

This study tests a new treatment called SR-02, which uses insulin-making cells implanted in the abdomen (omentum) of adults with type 1 diabetes who have dangerous low blood sugar episodes. The goal is to see if the implant is safe and can help the body produce its own insulin ag…

This study looks at whether using a continuous glucose monitor (CGM) helps people with diabetes who are on dialysis keep their blood sugar in a healthy range. About 96 adults with type 1 or type 2 diabetes and on either hemodialysis or peritoneal dialysis will be split into three…

This study follows 188 children and adolescents who completed the PROTECT study to see how safe teplizumab is over an extra 42 months. No new treatment is given—just monitoring for side effects and diabetes control. The goal is to understand long-term risks and benefits for manag…

This study tests the safety of transplanting donor islet cells into people with difficult-to-control type 1 diabetes. The goal is to see if the cells can help stabilize blood sugar and reduce the need for insulin injections. Participants also receive anti-rejection drugs to prote…

This study tests the safety of a 14-day treatment with teplizumab in 20 children under 8 years old who have early-stage (Stage 2) type 1 diabetes. The goal is to see if the drug is safe and how the body processes it. Teplizumab aims to slow down the disease and delay the need for…

This study tests two oral drugs (abrocitinib and ritlecitinib) in people aged 12–35 who were diagnosed with type 1 diabetes within the past 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, reducing the need for injected…

This study tests whether taking metformin daily during early pregnancy can prevent preeclampsia and other high blood pressure disorders in women with type 1 diabetes. About 60 pregnant women will take metformin or receive usual care starting before 20 weeks. The goal is to see if…

This study tests a treatment called Diamyd® in children aged 8 to 17 who are at high risk for type 1 diabetes. The goal is to see if giving the drug directly into lymph nodes is safe and can delay or prevent the disease from developing. Only 5 children with a specific genetic mar…

This study tests whether a program that combines a smartphone app with face-to-face therapy sessions can improve psychological well-being in children and adolescents with type 1 diabetes. About 122 young participants will use the app and attend therapy to learn skills for managin…

This study tests a 6-month program called Type 1 Together for teens aged 12-17 with type 1 diabetes who don't use a continuous glucose monitor (CGM) regularly. Participants get monthly meetings with a diabetes expert, access to educational app resources, and a mentor family to he…

This study tests whether virtual peer groups can help Latinx teenagers with type 1 diabetes use insulin pumps and continuous glucose monitors more often. About 120 teens and their caregivers will join online and in-person sessions to share experiences and get support. The goal is…

This study looks at how repeated low blood sugar (hypoglycemia) changes the brain's ability to sense danger in people with type 1 diabetes. Researchers will use brain scans to measure sugar levels in the brain before and after causing mild low blood sugar episodes. The goal is to…

This study looks at how people over 65 with type 1 diabetes age compared to those without diabetes. Researchers want to understand what helps them stay healthy and active as they get older. The study involves 400 participants from a long-term diabetes research project in Finland.

This study looks at whether adding mental health support to regular type 1 diabetes care can improve both mood and blood sugar levels. About 80 adults will fill out online surveys every six months for 18 months. Some will also have at least one talk session with a behavioral heal…