Smart insulin pumps put to the test in thousands of diabetes patients

NCT ID NCT04414280

Ongoing Disease control Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 1,600 people with type 1 diabetes, including young children aged 2-6, who use hybrid closed-loop insulin pumps (Medtronic, Tandem, or Omnipod). These devices automatically adjust insulin based on blood sugar readings but still require users to enter meal information. The goal is to see how well these pumps improve blood sugar control and quality of life over 24 months in real-world conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Hybrid closed-loop insulin pumps (Medtronic MiniMed 670G/780G, Tandem t:Slim X2 Control-IQ, Omnipod 5)

What this could lead to

If successful, this could show that automated insulin pumps help people with type 1 diabetes maintain better blood sugar levels with less effort, improving daily life and reducing complications.

What could go wrong

This is an observational study, not a controlled trial, so results may be influenced by other factors. The devices still require user input for meals, and long-term benefits or risks are not yet fully known.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 1

Contacts and locations

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Locations

AZ Delta

Roeselare, 8800, Belgium
AZ Delta - pediatrics

Roeselare, 8800, Belgium
AZ Groeninge - campus kennedylaan

Kortrijk, 8500, Belgium
AZ Oostende

Ostend, 8400, Belgium
AZ Sint-Jan

Bruges, 8000, Belgium
AZ Sint-Jan - pediatrics

Bruges, 8000, Belgium
AZ Turnhout - pediatrics

Turnhout, 2300, Belgium
AZORG

Aalst, 9300, Belgium
CHR Citadelle

Liège, 4000, Belgium
CHR Citadelle - pediatrics

Liège, 4030, Belgium
CHU Helora

Mons, 7000, Belgium
CHU UCL Namur - pediatrics

Yvoir, 5530, Belgium
CHU de Liège - site du Sart Tilman

Liège, 4000, Belgium
Clinique CHC Montlégia

Liège, 4000, Belgium
Clinique CHC Montlégia - pediatrics

Liège, 4000, Belgium
Cliniques Universitaires St. Luc

Brussels, 1200, Belgium
Cliniques Universitaires St. Luc - pediatrics

Brussels, 1200, Belgium
GZA Ziekenhuizen - campus Sint-Augustinus

Wilrijk, 2610, Belgium
GZA Ziekenhuizen - campus Sint-Vincentius

Antwerp, 2018, Belgium
Grand Hôpital de Charleroi - pediatrics

Charleroi, 6000, Belgium
Hôpital Erasme

Brussels, 1070, Belgium
Hôpital Universitaire des Enfants Reine Fabiola - pediatrics

Brussels, 1020, Belgium
Hôpital d'Arlon

Arlon, 6700, Belgium
Imeldaziekenhuis

Bonheiden, 2820, Belgium
Jessa

Hasselt, 3500, Belgium
Jessa - pediatrics

Hasselt, 3500, Belgium
UZ Antwerpen

Edegem, 2650, Belgium
UZ Antwerpen - pediatrics

Edegem, 2650, Belgium
UZ Brussel

Jette, 1090, Belgium
UZ Brussel - pediatrics

Jette, 1090, Belgium
UZ Gent

Ghent, 9000, Belgium
UZ Gent - pediatrics

Ghent, 9000, Belgium
UZ Leuven

Leuven, Vlaams-Brabant, 3000, Belgium
VITAZ

Sint-Niklaas, 9100, Belgium
Vitaz - pediatrics

Sint-Niklaas, 9100, Belgium
ZAS - pediatrics

Antwerp, 2020, Belgium
ZOL Maas en Kempen - pediatrics

Maaseik, 3680, Belgium
ZOL Sint-Jan

Genk, 3600, Belgium