Can these pills save Insulin-Making cells in newly diagnosed type 1 diabetes?
NCT ID NCT05743244
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests two oral drugs, abrocitinib and ritlecitinib, in 78 people aged 12-35 who were diagnosed with type 1 diabetes within the last 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, measured by a stimulated C-peptide test after 12 months. Participants are randomly assigned to receive one of the drugs or a placebo, and the study is double-blind, meaning neither patients nor doctors know who gets what.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Abrocitinib and Ritlecitinib (JAK inhibitor drugs)
What this could lead to
If successful, this could lead to a treatment that helps people with newly diagnosed type 1 diabetes keep making some of their own insulin for longer, reducing the need for injected insulin.
What could go wrong
This is an early phase 2 trial with only 78 people, so results may not apply to everyone. JAK inhibitors can have side effects like increased infection risk, and the drugs may not work as hoped.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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3. Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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Barbara Davis Center at University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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Benaroya Research Institute
Seattle, Washington, 98101, United States
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Children's Hospital Orange County
Orange, California, 92868, United States
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Columbia University-Naomi Berrie Diabetes Center
New York, New York, 10032, United States
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Emory Children's Center
Atlanta, Georgia, 30322, United States
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Hospital for Sick Children
Toronto, Ontario, M5G1X8, Canada
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Indiana University
Indianapolis, Indiana, 46202, United States
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Joslin Center at SUNY Upsate
Syracuse, New York, 13210, United States
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Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
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Perth Children's Hospital
Nedlands, Western Australia, 6009, Australia
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Queensland Children's Hospital
South Brisbane, Queensland, 4101, Australia
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Royal North Shore Hospital
Saint Leonards, New South Wales, 2065, Australia
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Stanford University
Palo Alto, California, 94304, United States
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The Children's Mercy Hospital
Kansas City, Missouri, 64111, United States
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The Royal Children's Hospital - Melbourne
Melbourne, Victoria, 3052, Australia
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UBMD Pediatrics
Buffalo, New York, 14203, United States
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University of California- San Francisco
San Francisco, California, 94143, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Louisville Pediatric Endocrinology
Louisville, Kentucky, 40202, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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University of South Florida Diabetes Center
Tampa, Florida, 33612, United States
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University of Texas Southwestern
Dallas, Texas, 75390, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Women and Children's Hospital-Adelaide
Adelaide, South Australia, 5006, Australia
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Yale University School of Medicine
New Haven, Connecticut, 06511, United States