Could a TB vaccine help kids with type 1 diabetes?

NCT ID NCT05180591

Ongoing Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving the BCG vaccine (traditionally used for tuberculosis) twice, four weeks apart, can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control, reduces insulin use, and lowers the risk of dangerously low blood sugar. The trial is active but no longer recruiting new participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BCG vaccine (Bacillus Calmette-Guérin)
What this could lead to: If it works, this could offer a new way to help children with type 1 diabetes manage their blood sugar levels and reduce insulin needs.
What could go wrong: This is a mid-stage trial with 150 participants, so results are not yet proven. The BCG vaccine may not improve diabetes control, and side effects like injection-site reactions are possible.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DIABETES DIABETES MELLITUS, TYPE 1 DIABETES TYPE1

Contacts and locations

Locations

Immunobiology Labs CNY 149

Charlestown, Massachusetts, 02129, United States

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