Could a pill delay diabetes in kids? new trial hopes so

NCT ID NCT07222137

Recruiting now Prevention Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insulin treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: baricitinib
What this could lead to: If successful, this could provide a way to delay or prevent type 1 diabetes in children at high risk, potentially avoiding lifelong insulin dependence.
What could go wrong: This is an early phase 3 trial with only 150 participants, so results may not apply to everyone. Baricitinib is an immunosuppressant and may have side effects like increased infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus type 1 diabetes mellitus 1 type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 1

Contacts and locations

Locations

2Ca Braga
RECRUITING

Braga, 4710-243, Portugal
Abeno Medical Clinic
RECRUITING

Abeno, 545-0052, Japan
Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 2QQ, United Kingdom
Akershus Universitetssykehus
RECRUITING

Lørenskog, 1478, Norway
Alberta Children's Hospital
NOT_YET_RECRUITING

Calgary, T3B 6A8, Canada
Alberta Diabetes Institute
NOT_YET_RECRUITING

Edmonton, T6G 2E1, Canada
Antwerp University Hospital
NOT_YET_RECRUITING

Edegem, 2650, Belgium
Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T
NOT_YET_RECRUITING

Paris, 75019, France
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
NOT_YET_RECRUITING

Marseille, 13385, France
Azienda Ospedale - Università Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
RECRUITING

Verona, 37126, Italy
Azienda Ospedaliera Universitaria Meyer IRCCS
RECRUITING

Florence, 50139, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
RECRUITING

Novara, 28100, Italy
BC Diabetes Office
RECRUITING

Vancouver, V5Y 3W2, Canada
Birmingham Children's Hospital
NOT_YET_RECRUITING

Birmingham, B4 6NH, United Kingdom
Box Hill Hospital
RECRUITING

Box Hill, 3128, Australia
CHU Rangueil
NOT_YET_RECRUITING

Toulouse, 31059, France
CHU UCL Namur/Site Sainte Elisabeth
NOT_YET_RECRUITING

Namur, 5000, Belgium
CPCLIN
RECRUITING

São Paulo, 01228-200, Brazil
Carmel Hospital
NOT_YET_RECRUITING

Haifa, 3436212, Israel
Cendi - Endocrinologia e Diabetes
RECRUITING

Goiânia, 74230-035, Brazil
Centre Hospitalier Sud Francilien
NOT_YET_RECRUITING

Corbeil-Essonnes, 91106, France
Centre for Children's Health Research
RECRUITING

Brisbane, 4101, Australia
Centro Materno Infantil do Norte
RECRUITING

Porto, 4050, Portugal
Centro de Diabetes Curitiba
RECRUITING

Curitiba, 80810-040, Brazil
Centro de Pesquisa Clínica de Marília - CPCLIM
RECRUITING

Marília, 17504-072, Brazil
Children's Hospital of Philadelphia (CHOP)
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cliniques universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, 1200, Belgium
Diabeter - Rotterdam
RECRUITING

Rotterdam, 3011 TA, Netherlands
Freire Pesquisa Clínica
RECRUITING

Belo Horizonte, 30150-320, Brazil
Hadassah Medical Center
RECRUITING

Jerusalem, 9112001, Israel
Hannoversche Kinderheilanstalt
RECRUITING

Hanover, 30173, Germany
Haukeland Universitetssjukehus
RECRUITING

Bergen, 5021, Norway
Hopital Claude Huriez - CHU de Lille
NOT_YET_RECRUITING

Lille, 59037, France
Hopitaux Universitaires Paris Centre-Hopital Cochin
NOT_YET_RECRUITING

Paris, 75014, France
Hospices Civils de Lyon - Hopital Louis Pradel
NOT_YET_RECRUITING

Bron, 69677, France
Hospital Sant Joan de Déu
RECRUITING

Esplugues de Llobregat, 08950, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Walter Cantidio
RECRUITING

Fortaleza, 60430-270, Brazil
Hospital das Clinicas FMUSP
RECRUITING

São Paulo, 05403-000, Brazil
Hôpital Universitaire Necker Enfants Malades
NOT_YET_RECRUITING

Paris, 75015, France
IBTED - Tecnologia e Educação em Diabetes
RECRUITING

São Paulo, 04038-032, Brazil
IRCCS - AOU di Bologna
RECRUITING

Bologna, 40138, Italy
Institute of Diabetes, Technology and Research - Clalit Health
RECRUITING

Herzliya, 4600201, Israel
Instituto de Pesquisa Clinica
RECRUITING

São Paulo, 01223-001, Brazil
Iowa Diabetes and Endocrinology Research Center
RECRUITING

West Des Moines, Iowa, 50266, United States
Jinnouchi Hospital
RECRUITING

Kumamoto, 862-0976, Japan
Kaplan Medical Center
RECRUITING

Rehovot, 7610001, Israel
Klinik Josefinum
NOT_YET_RECRUITING

Augsburg, 86154, Germany
MTZ Clinical Research Powered by Pratia
NOT_YET_RECRUITING

Warsaw, 02-172, Poland
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
RECRUITING

Warsaw, 04-501, Poland
Meir Medical Center
RECRUITING

Kfar Saba, 4428164, Israel
Nagano Municipal Hospital
RECRUITING

Nagano, 381-8551, Japan
Nakakinen clinic
RECRUITING

Naka, 311-0113, Japan
Niigata University Medical & Dental Hospital
RECRUITING

Niigata, 951-8520, Japan
Nippon Medical School Musashi Kosugi Hospital
RECRUITING

Kawasaki, 211-8533, Japan
Noah's Ark Children's Hospital for Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
Novak Center for Children's Health
NOT_YET_RECRUITING

Louisville, Kentucky, 40202, United States
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
RECRUITING

Barakaldo, 48903, Spain
Oslo Universitetssykehus Aker
RECRUITING

Oslo, 0586, Norway
Oslo Universitetssykehus Ullevål
RECRUITING

Oslo, 0450, Norway
Ospedale Microcitemico
NOT_YET_RECRUITING

Cagliari, 09121, Italy
Ospedale Pediatrico Salesi
RECRUITING

Ancona, 60123, Italy
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Oulun yliopistollinen sairaala
RECRUITING

Oulu, 90220, Finland
Perth Children's Hospital
RECRUITING

Perth, 6009, Australia
Pitie Salpetriere University Hospital
NOT_YET_RECRUITING

Paris, 75013, France
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B15 2TH, United Kingdom
Queen Elizabeth University Hospital
NOT_YET_RECRUITING

Glasgow, G51 4TF, United Kingdom
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, 4029, Australia
Royal Children's Hospital
NOT_YET_RECRUITING

Melbourne, 3052, Australia
Royal London Hospital
RECRUITING

London, E1 1BB, United Kingdom
Saitama Medical University Hospital
RECRUITING

Iruma, 350-0495, Japan
Schneider Children's Medical Center
RECRUITING

Petah Tikva, 4920235, Israel
Seino Internal Medicine Clinic
RECRUITING

Kōriyama, 963-8851, Japan
Sheba Medical Center
RECRUITING

Ramat Gan, 5262100, Israel
Sheba Medical Center
NOT_YET_RECRUITING

Ramat Gan, 5262100, Israel
Skånes Universitetssjukhus Malmö
RECRUITING

Malmö, 21428, Sweden
Soroka Medical Center
RECRUITING

Beersheba, 8410101, Israel
Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Southampton General Hospital
RECRUITING

Southampton, SO16 6YD, United Kingdom
St. George's Hospital
RECRUITING

London, SW17 0QT, United Kingdom
Stavanger Universitetssykehus
RECRUITING

Stavanger, 4011, Norway
Sydney Children's Hospital
RECRUITING

Randwick, 2031, Australia
TUM Klinikum
RECRUITING

München, 80939, Germany
Tallahassee Memorial HealthCare
NOT_YET_RECRUITING

Tallahassee, Florida, 32308, United States
Tampereen yliopistollinen sairaala
RECRUITING

Tampere, 33520, Finland
The Children's Hospital at Westmead
RECRUITING

Westmead, 2145, Australia
The John Radcliffe Hospital
RECRUITING

Oxford, OX3 9DU, United Kingdom
The Royal Melbourne Hospital
RECRUITING

Parkville, 3050, Australia
Turku University Hospital
RECRUITING

Turku, 20520, Finland
ULSAM - Hospital de Santa Luzia
RECRUITING

Viana do Castelo, 4900-858, Portugal
UZ Brussel
NOT_YET_RECRUITING

Brussels, 1090, Belgium
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Unidade Local De Saude De Gaia/Espinho E.P.E.
NOT_YET_RECRUITING

Vila Nova de Gaia, 4434-502, Portugal
Unidade Local de Saude de Matosinhos
RECRUITING

Matosinhos Municipality, 4464-513, Portugal
Universidade Federal do Rio de Janeiro
RECRUITING

Rio de Janeiro, 21941-590, Brazil
Universitaetsklinikum Augsburg
RECRUITING

Augsburg, 86156, Germany
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
NOT_YET_RECRUITING

Dresden, 01307, Germany
Universitetssjukhuset Örebro
RECRUITING

Örebro, 701 85, Sweden
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Naples Federico II
RECRUITING

Naples, 80100, Italy
University of Naples Federico II
RECRUITING

Naples, 80131, Italy
University of South Florida
SUSPENDED

Tampa, Florida, 33612, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Women's and Children's Hospital
RECRUITING

Adelaide, 5006, Australia
Yamanashi Prefectural Central Hospital
RECRUITING

Kofu, 400-8506, Japan
Yitzhak Shamir Medical Center
RECRUITING

Beer Yaacov, 70300, Israel

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