Double transplant aims to cure diabetes in kids with weak immune systems

NCT ID NCT03835312

Recruiting now Disease control Sponsor: Children's Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a two-step transplant for children with type 1 diabetes who also have an immune deficiency. First, they receive umbilical cord blood stem cells to rebuild their immune system. Then, if that works well, they get a transplant of insulin-producing islet cells. The goal is to help their bodies make insulin again and improve their overall health. The trial is currently recruiting 50 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: umbilical cord blood stem cells and islet cells
What this could lead to: If it works, this could help children with type 1 diabetes and immune deficiency produce their own insulin again and reduce the need for daily insulin shots.
What could go wrong: This is an early-stage trial with only 50 participants. The procedure involves chemotherapy and immunosuppressive drugs, which carry risks like infection and graft-versus-host disease. Success is not guaranteed.

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Conditions

The condition(s) this trial relates to.

immunodeficiency disease inborn error of immunity monogenic diabetes type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 1 IMMUNOLOGIC DEFICIENCY SYNDROMES

Contacts and locations

Locations

Children's Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, China

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