Children's Hospital Of Fudan University

This study follows five patients with beta-thalassemia for two years after they received an experimental gene therapy called CS-101. The goal is to monitor the long-term safety of the treatment and see if patients remain free from needing blood transfusions. Researchers will trac…

This study is testing a potential cure for children with a rare, severe form of type 1 diabetes caused by an immune system defect. Doctors will first give children a transplant of umbilical cord blood stem cells to fix their immune system. If that works, they will then receive a …

This study is testing whether hydroxychloroquine, a medication used for malaria and autoimmune diseases, can help children with rare genetic lung disorders breathe easier. Researchers will compare children who receive the drug to those who don't to see if it improves oxygen level…

This study is testing whether a continuous blood filtering treatment helps children with severe bloodstream infections (sepsis) survive and recover better than standard care. Researchers will compare two groups of children to see if early use of this blood purification improves 2…

This 3-year study is testing a new remote therapy program called STAR, designed to help parents learn skills to support their toddlers with autism. The trial will compare the STAR program, delivered online, to standard community care. Researchers aim to see if this accessible, pa…

This study is testing whether dietary supplements called prebiotics and probiotics can help control appetite and weight gain in children with Prader-Willi syndrome, a rare genetic disorder that causes constant hunger and severe obesity. Sixty children will be divided into groups …

This study is looking back at past medical records to see if a treatment called gamma globulin helps children with severe infections. These children have a dangerous overreaction of their immune system, called an inflammatory storm, which can lead to organ failure. Researchers wi…

This study is testing whether a combination of traditional Chinese herbal medicine and small, shallow acupuncture needles can help slow down early puberty in girls. Researchers want to see if this approach can reduce early breast development and delay bone maturation compared to …

This study is testing whether a 12-week high-fiber diet can help protect the body's ability to produce insulin in children recently diagnosed with type 1 diabetes. Researchers will compare children who follow the special diet to those who receive usual care. They will measure ins…

This study is testing whether a drug called infliximab works better alone or when combined with other immunosuppressive medications to control Crohn's disease in children. It will involve 128 children aged 6-18 who have active Crohn's disease. The main goal is to see which approa…

This study is looking at a medication called dupilumab for children with a severe, hard-to-treat form of stomach and gut inflammation. It aims to see if the drug can help heal ulcers and reduce inflammation in kids who haven't responded well to other treatments. The researchers w…

This study is testing two different types of filters used in a blood-cleaning treatment for children with sepsis, a life-threatening response to infection. The goal is to see which filter is better at removing harmful inflammation-causing substances from the blood, which could he…

This study is testing whether a time-efficient exercise program called High-Intensity Interval Training (HIIT) can improve heart and metabolic health in children and teens who already show early warning signs. It will involve 336 participants aged 7-18 who have conditions like pr…

This small pilot study is testing a specific, lower dose of the blood thinner rivaroxaban in Chinese children who have developed a giant bulge (aneurysm) in their heart arteries after Kawasaki disease. The goal is to see if this dose is safe and effective at preventing dangerous …

This study aims to find out if a more comprehensive genetic test (whole genome sequencing) is better than a standard one (whole exome sequencing) at identifying the genetic causes of chronic diarrhea and intestinal problems in infants. Researchers will enroll 180 infants and rand…

This study is testing whether a faster genetic sequencing technology can improve how quickly doctors diagnose birth defects and genetic diseases in newborns. It will involve 2,000 babies in neonatal intensive care units who have unexplained health problems. The goal is to see if …

This study aims to see if measuring a substance in the blood called copeptin can help doctors quickly diagnose a water-balance disorder called central diabetes insipidus (CDI) in children after brain surgery. Researchers will track copeptin levels in 100 children in the intensive…

This study is testing a coordinated care plan designed to prevent children from becoming dependent on breathing machines (ventilators). The plan involves carefully timed rehabilitation, nutrition support, and procedures like tracheostomies. Researchers will compare children recei…

This study is testing whether a special nurturing approach called 'developmental care' helps very small premature babies. Researchers want to see if this gentle care helps babies leave the hospital sooner and allows families to be more involved in their care. The study involves 4…

This study is testing a new program where nurses start conversations about palliative care early in a child's cancer treatment. It aims to see if these regular talks improve the child's quality of life, manage symptoms better, and reduce stress for family caregivers compared to s…

This study aims to understand how social behaviors and brain connections develop differently in infants who have a higher chance of developing autism. Researchers will follow 100 infants from 3 months to 3 years old, comparing those with an autistic sibling to those without. The …

This study aims to create a large database and sample bank for newborns with serious brain conditions. It will collect medical information and samples like blood and urine from up to 2,000 babies across China. The goal is to use this 'big data' to better understand these conditio…

This study aims to better understand severe infections in children who are critically ill and admitted to pediatric intensive care units (PICUs) across China. Researchers will collect information from 2,000 patients over ten years to track what germs cause infections, how they ar…

This large, multi-hospital project aims to improve the safety and success of placing feeding tubes in children. It will review the latest medical evidence, update nurse training, and create standardized procedures to reduce errors. The goal is to ensure hospitalized children rece…

This study aims to understand how well a life-support machine called ECMO has worked for critically ill children in China over the past 10 years. Researchers will review the medical records of up to 500 children who received this treatment. The main goal is to learn about surviva…

This large research project aims to collect genetic information from 100,000 newborns in China over five years. The goal is to build a national database of newborn genes to understand how common certain inherited diseases are. This information will help create better standards fo…

This study aims to collect detailed information from 5,000 children in China who have severe infections like sepsis or pneumonia. The goal is to understand how common these illnesses are, what treatments work best, and to create better tools for predicting and diagnosing them. It…

This study aims to better understand a rare form of chronic diarrhea in children called congenital diarrhea and enteropathy (CODE). Researchers will collect detailed health information from 60 children with CODE and use advanced lab tests to look for biological markers. The goal …

This study aims to understand how common seizures are in newborn babies in China and what factors might increase the risk. Researchers will monitor 1,400 newborns (0-28 days old) who have been diagnosed with seizures, using brain wave tests (EEG) and collecting health information…

This study aims to understand the genetic causes of seizures in babies under one year old. Researchers will perform genetic tests on 2000 infants in China to identify patterns and see how current treatments work. The goal is to gather knowledge that could lead to more personalize…

This study looks back at medical records to understand what makes children in a pediatric intensive care unit (PICU) more likely to get or carry dangerous, drug-resistant bacteria called CRE. Researchers will analyze data from over 500 children hospitalized between 2018 and 2019.…

This study is testing a planning tool to see if it helps nurses make better choices when selecting intravenous (IV) lines for children in the hospital. Researchers will see if using the tool improves nurses' knowledge and reduces mistakes in picking the right type of IV device. T…

This study aims to understand how the bodies of critically ill children process the antifungal drug caspofungin. It will observe 60 children in intensive care who are already receiving this medication. The goal is to gather data to help doctors determine the safest and most effec…