Children's Hospital Of Fudan University

This phase 3 trial is testing whether atorvastatin, a common cholesterol drug, is safe and can reduce inflammation in children with Kawasaki disease who also have coronary artery abnormalities. The study will enroll 9 children and give them different doses of atorvastatin for 6 w…

This study tests whether giving oral antibiotics after Kasai surgery can prevent cholangitis, a serious bile duct infection, in infants with biliary atresia. About 356 babies will be randomly assigned to receive either preventive antibiotics or standard care, and they will be fol…

This study tests a new smart device that automatically lowers the dose of inhaled nitric oxide in newborns with persistent pulmonary hypertension. The device aims to make the weaning process safer and more consistent by using a gradual, real-time reduction instead of manual step …

This study tests whether a high-energy diet helps infants with congenital heart disease grow and develop their brains better after heart surgery. Researchers will compare high-energy versus standard nutrition in 160 babies aged 0-6 months. The goal is to see if the special diet i…

This study tests whether probiotics and prebiotics can safely help control appetite and weight gain in 60 children with Prader-Willi syndrome, a rare genetic condition that causes severe obesity. Researchers will measure changes in body mass index, body fat, and gut bacteria over…

This study tests a two-step transplant for children with type 1 diabetes who also have an immune deficiency. First, they receive umbilical cord blood stem cells to rebuild their immune system. Then, if that works well, they get a transplant of insulin-producing islet cells. The g…

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (feeling better and showing heal…

This study compares two non-drug approaches for helping obese children lose weight: ear acupressure (sticking tiny seeds on ear points) and an intermittent low-carbohydrate diet. Researchers will track changes in body weight and other health markers over three months in 240 child…

This study is testing whether a high-fiber supplement called Trimtab can help preserve beta-cell function in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. For 12 weeks, participants will take the supplement daily, and researchers will measure C-peptide l…

This study looks at whether giving gamma globulin to children with severe infections and inflammatory storms can lower death rates and shorten time in the intensive care unit. Researchers will compare 200 children who received gamma globulin with those who did not. The goal is to…

This study tests whether hydroxychloroquine, a drug used for malaria and arthritis, can safely improve breathing in children with interstitial lung disease caused by genetic mutations. Researchers will enroll 60 children and randomly assign them to receive the drug or not, measur…

This study looks at whether continuous blood purification (a slow, steady filtering of the blood) works better than standard non-continuous methods for children with severe sepsis. Researchers will track survival rates and kidney function in 90 children aged 29 days to 18 years. …

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive a team-based nutrition plan including special diets. The goal is to improve weight, height, and overall health during treatment.

This study tests whether a combination of Chinese herbs (Ziyin-Xiehuo granules) and tiny acupuncture needles placed under the skin can help girls with idiopathic precocious puberty. The 170 participants will receive either the herbs plus acupuncture or a placebo. Researchers will…

This study tests a developmental care program for very low birth weight infants (under 1500 grams). The program includes controlling light, noise, and sleep, plus encouraging skin-to-skin contact. Researchers want to see if it shortens hospital stays and increases family involvem…

This study tests whether a heart-lung bypass machine (ECMO) can help children with severe septic shock survive. Researchers will enroll 60 children and track how many leave the hospital alive. They also want to find the best time to start ECMO and which factors affect success.

This study tests a combination of early rehabilitation, nutrition support, and early tracheotomy to prevent children from becoming dependent on mechanical ventilators. Researchers will enroll 150 stable children on ventilators and compare the bundle approach to standard care. The…

This study compares two types of blood purification membranes (AN69ST and polysulphone) in 80 children with sepsis, ages 29 days to 18 years. The goal is to see which membrane better reduces inflammatory cytokines and organ damage. Children receive continuous blood purification f…

This study tests whether a special high-intensity interval training (HIIT) program can improve heart health in school-age children who are at high risk for cardiovascular disease. The program involves short bursts of intense exercise, done several times a week. Researchers will t…

This study is testing the drug dupilumab in 20 children whose eosinophilic gastrointestinal disorders have not responded to other treatments. The goal is to see if dupilumab can heal ulcers and reduce inflammation in the stomach and gut. Children receive injections every one or t…

This study follows 5 people with β-thalassemia who received CS-101, a gene-edited stem cell therapy, in an earlier trial. Researchers will monitor them for years to see if the treatment remains safe and allows them to stay free from blood transfusions. The goal is to understand w…

This pilot study tests the blood thinner Rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms after Kawasaki disease. The goal is to see if a specially adjusted dose can prevent new blood clots in the heart arteries while keeping bleeding risks low. Ch…

This study will screen 13,000 children in China using urine tests and ultrasound to find kidney disease early. The goal is to see how common kidney problems are in kids and to build a system to predict who is at risk. Children with abnormal results will be referred for further ca…

This study tests whether whole genome sequencing (looking at all DNA) finds more answers than whole exome sequencing (looking at just the protein-making parts) for children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test or th…

This study tests whether specially trained nurses can help children with cancer and their families by starting conversations about palliative care early. About 120 children recently diagnosed with cancer will be randomly assigned to either receive these nurse-led talks or standar…

This study tests a remote therapy model called STAR for toddlers with autism. 110 children will be split into two groups: one receiving STAR therapy plus community care, and the other receiving only community care. The goal is to see if STAR improves social and communication skil…

This study aims to screen 15,000 children aged 1-3 and their parents for familial hypercholesterolemia, a genetic condition that causes very high cholesterol and early heart disease. Researchers will use a simple finger-prick blood test to measure cholesterol and check for specif…

This study looks at how a special high-MCT (medium-chain triglyceride) diet affects growth in infants with biliary atresia after Kasai surgery. Researchers will track weight and length in 300 babies under 3 months old. The goal is to gather information, not to test a new treatmen…

This study watches 110 infants under 6 months who had a bowel ostomy to see how early feeding affects their weight and growth. Researchers will track weight, length, and stoma output over time. The goal is to learn more, not to test a new treatment.

This study is looking at whether a substance called FGF19 in the blood, measured before surgery, can help predict how well children with biliary atresia will do after their operation. Researchers will follow 200 children for one year after surgery, checking liver function and whe…

This study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…

This study reviews medical records of over 500 children in a pediatric intensive care unit (PICU) to find out what makes them more likely to get or carry a hard-to-treat bacteria called CRE. The goal is to identify risk factors and understand the bacteria better. The results coul…

This study is collecting genetic information from 2,000 infants in China who had seizures before their first birthday. Researchers aim to find gene changes linked to seizures and see if personalized treatments can help control them better. The goal is to understand the genetic ca…

This project will sequence the genes of 100,000 newborns in China over five years. The goal is to create a large genetic database, find how often gene changes occur, and improve testing for inherited diseases. Participants are healthy babies under 28 days old with Chinese parents…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study will gather health information from 5,000 children in China who have severe infections like pneumonia or sepsis. The goal is to learn how common these infections are, how well different treatments work, and to create tools that can predict which children are at highest…

This study follows 100 infants and toddlers with either a high or low family risk of autism spectrum disorder (ASD). Researchers will track how prosocial behaviors—like helping and understanding others—develop, along with brain network changes measured by EEG and MRI. The goal is…

This study looks back at the past 10 years to understand how a life-support machine called ECMO has been used in children across China. Researchers will gather information from 500 children, from newborns to 18-year-olds, to see how many survive after treatment, how long they nee…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at whether measuring a substance called copeptin in the blood can help doctors diagnose central diabetes insipidus (CDI) in children after brain surgery. CDI causes extreme thirst and frequent urination due to a hormone imbalance. The study will track copeptin le…

This study tests whether a special matching tool helps nurses pick the right IV device for children. About 394 nurses will use the tool and their choices will be compared to a group that doesn't use it. The goal is to see if the tool lowers mistakes and improves nurses' knowledge…

This study looks at 60 children with congenital diarrhea and enteropathy (CODE) in China. Researchers will collect medical history, blood, and stool samples to find biological markers and build a risk prediction model. No new treatment is being tested; the goal is to better under…

This project involves 2,750 children across multiple hospitals to improve how nurses insert gastric tubes. The team will train nurses using the latest evidence-based methods to increase success rates and reduce complications. The goal is to make the procedure safer and more consi…

This large observational study is tracking 1,400 newborns in China who have seizures. Researchers will use EEG to record brain activity and follow the babies' development over time. The goal is to better understand how common newborn seizures are and how they affect long-term hea…

This study aims to create a large database of medical information and biological samples from 2,000 newborns with brain conditions like encephalopathy. Researchers will collect blood, urine, and spinal fluid samples, along with genetic data, to better understand and monitor brain…

This study is testing whether using rapid genetic sequencing can help doctors diagnose and treat birth defects in newborns in intensive care. Researchers will enroll 2,000 babies and compare death rates, disability rates, and genetic findings. The goal is to see if personalized t…