Children's Hospital Of Fudan University

This study tests if ear acupressure (stimulating points on the ear) can help obese children lose weight, compared to a diet that limits carbs on some days. The trial will include 240 children who have weight-related health risks and a specific pattern in Chinese medicine. The mai…

This study follows 5 people with beta-thalassemia who already received a one-time gene therapy called CS-101. Researchers want to see if the treatment remains safe and effective over many years, including whether patients can stay free from blood transfusions. The study does not …

This study looks at whether a special diet high in medium-chain triglycerides (MCTs) can help infants with biliary atresia grow better after Kasai surgery. About 300 infants under 3 months old who had the surgery will be followed. Researchers will track weight and length to see i…

This study is testing whether a 12-week high-fiber diet can help protect the beta-cells (the cells that make insulin) in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. The goal is to see if this dietary change can slow the loss of insulin production. Part…

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive either standard care or a team-based nutrition plan that includes special short-peptide supplements. The goal is to improve weight, heig…

This study tests if hydroxychloroquine, a medicine used for malaria and some immune conditions, can improve breathing in children with a rare genetic lung disease. About 60 children under 18 with a confirmed genetic cause will be randomly assigned to receive the drug or not. Rese…

This study looks at two ways to clean the blood in children with sepsis, a life-threatening infection. It compares continuous blood purification (done without stopping) to non-continuous methods. The goal is to see which approach helps more children survive 28 days after leaving …

This study looks at whether giving gamma globulin (a blood product with antibodies) can help children in the ICU who have severe infections and a dangerous overreaction called an inflammatory storm. The goal is to see if it lowers the risk of death and shortens time in the ICU. R…

This study tests whether a combination of Chinese herbs and intradermal acupuncture can help slow down or reverse early puberty in girls. About 170 girls diagnosed with idiopathic precocious puberty will receive either the treatment or a control. The main goal is to see if breast…

This study tests a new 'smart' feature on a machine that delivers inhaled nitric oxide to newborns with a serious lung condition called PPHN. Normally, doctors manually lower the gas dose step by step, which can be inconsistent and time-consuming. The smart device automatically r…

This study looks at whether probiotics and prebiotics can safely help control appetite and weight gain in 60 children with Prader-Willi syndrome, a rare genetic condition that causes severe obesity. Researchers will measure changes in body mass index, body fat, and gut bacteria o…

This study tests a personalized dose of the blood thinner rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms (large bulges in heart arteries) after Kawasaki disease. The goal is to see if the dose safely prevents new blood clots and major heart probl…

This study tests a bundle of early treatments—including intensive rehabilitation, nutrition support, and possible tracheotomy—to prevent children from becoming dependent on mechanical ventilation. Researchers will enroll 150 stable children on breathing machines and compare their…

This study looks at whether high-intensity interval training (HIIT) can help improve heart and metabolic health in children aged 7 to 18 who are at high risk for heart disease. Researchers will measure if HIIT can reverse early signs of problems like prediabetes, abnormal cholest…

This study looks at whether dupilumab can help children with severe eosinophilic gastrointestinal disorders (EGIDs) that haven't responded to other treatments. About 20 children will receive the drug to see if it heals ulcers and lowers inflammation in the gut. The goal is to con…

This study is for children with a rare form of type 1 diabetes that also involves a weak immune system. Doctors first transplant umbilical cord blood stem cells to rebuild the immune system, then transplant islet cells to help the body make insulin again. The goal is to see if th…

This study tests two types of blood purification filters (AN69ST and polysulphone) in 80 children with sepsis. The goal is to see which filter better reduces harmful inflammatory substances and organ damage. Children aged 29 days to 18 years with sepsis-related organ failure may …

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (symptom-free and healed gut) af…

This study compares two genetic tests—whole genome sequencing and whole exome sequencing—to see which one better diagnoses children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test. The goal is to find the cause faster and guid…

This study will test whether a special brain scan called magnetoencephalography (MEG) can help doctors better diagnose children with conditions like epilepsy, autism, ADHD, and brain tumors. Researchers will compare MEG signals from 1500 children with these disorders to signals f…

This study tests whether giving daily oral antibiotics to infants with biliary atresia after Kasai surgery can prevent cholangitis, a serious liver infection. About 356 babies will be randomly assigned to receive antibiotics or not, and their health will be tracked for two years.…

This study tests a special care plan for very low birth weight babies (under 1500 grams) in 40 hospital intensive care units. The goal is to see if this care helps babies leave the hospital sooner and spend more time being held skin-to-skin by their parents. About 1600 babies wil…

This study tests a program where nurses start conversations about palliative care early for children with cancer. The goal is to see if this improves the child's quality of life and reduces side effects. About 120 children and their families will take part, with some getting the …

This study tests a new remote therapy program called STAR for toddlers with autism spectrum disorder (ASD). About 110 children will be split into two groups: one receives STAR therapy plus standard community care, the other only community care. The goal is to see if STAR helps im…

This study aims to find kidney disease early in children by using simple urine tests and ultrasound scans. About 13,000 children from China will be screened and followed for 3-6 years. Those with abnormal results will get further care. The goal is to better understand and prevent…

This study looks at how the antibiotic ceftazidime avibactam behaves in children with severe infections who are on life support. Researchers want to find the right dose by measuring drug levels in the blood. About 30 children in the ICU will take part. The goal is to improve trea…

This project will sequence the genes of 100,000 newborns in China over five years. The goal is to create a large genetic database, find how common gene mutations are, and set standards for genetic testing. It does not offer treatment but will help understand hereditary diseases i…

This study gathers health information from 5000 children (0-18 years) with severe pneumonia or sepsis across multiple hospitals in China. Researchers will analyze this data to learn how common severe infections are, what treatments work best, and how to predict which children are…

This study is observing 1,400 newborns in China who have seizures to find out how common they are and how they affect brain development. Doctors will use EEG to record brain activity and track the babies' progress over time. The goal is to better understand and diagnose seizures …

This study looks at whether a special matching tool helps nurses choose the best IV device for children. About 394 nurses will use the tool and record their choices. The goal is to see if the tool improves nurses' knowledge and reduces errors in selecting the right IV device.

This study looks at whether measuring a substance called copeptin in the blood can help doctors diagnose central diabetes insipidus (CDI) in children after brain surgery. CDI causes extreme thirst and frequent urination. The study will follow 100 children in the ICU after neurosu…

This study looks at whether a substance called FGF19 in the blood, measured before surgery, can help predict how well children with biliary atresia will recover. Researchers will follow 200 children for one year after surgery to see if FGF19 levels are linked to liver health and …

This study looks at children with a rare, severe form of diarrhea that starts early in life. Researchers will collect medical information and samples to find patterns and markers in the body. The goal is to better understand the condition and create a tool to predict risks. No ne…

This study is creating a large database of medical information, genetic data, and biological samples from 2,000 newborns with brain conditions like encephalopathy. The goal is to use this big data to better predict brain injury and guide treatment. It does not test a new treatmen…

This study watches how babies and toddlers at high or low risk for autism develop helpful behaviors and brain connections. Researchers will use play-based tests, EEG, and MRI scans during natural sleep to compare the two groups. The goal is to understand early differences that ma…

This study aims to collect and analyze data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Researchers will track which germs cause infections, how often children survive, and what treatments are used. Th…

This project works with nurses at multiple children's hospitals to improve how they place feeding tubes in young patients. The team will compare current methods to the latest evidence, train nurses on best practices, and track whether this leads to fewer complications and more su…

This study reviews medical records of children in the pediatric intensive care unit (PICU) to find out what makes them more likely to get or carry a hard-to-treat bacteria called CRE. Researchers will look at data from over 500 children to identify risk factors and understand the…

This study is testing whether advanced genetic testing can help doctors diagnose birth defects and genetic diseases faster in newborns in intensive care. By analyzing the babies' DNA, researchers hope to improve diagnosis rates and guide personalized treatments. The study will en…

This study watches how tube feeding affects weight and length in 110 infants under 6 months who had bowel surgery. It does not test any new treatment or medicine. The goal is to learn more about nutrition in these babies.

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing better. The goal is to improve treatme…