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Could a once-daily pill replace warfarin for kids with rare heart aneurysms?

NCT ID NCT05643651

Recruiting now Disease control Sponsor: Children's Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial compares two blood thinners—rivaroxaban (Xarelto) and warfarin—in children over 2 years old who have giant coronary artery aneurysms caused by Kawasaki disease. The goal is to see if rivaroxaban is safer and as effective as warfarin at preventing blood clots, major bleeding, and heart complications over three months. All children also receive an antiplatelet drug like aspirin or clopidogrel.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Rivaroxaban (Xarelto)
What this could lead to
If it works, this could offer a simpler, more predictable alternative to warfarin for preventing dangerous blood clots in children with giant coronary aneurysms after Kawasaki disease.
What could go wrong
This is an early exploratory trial with only 100 children, so results may not be definitive. Rivaroxaban could still cause bleeding or fail to prevent clots as well as warfarin.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary aneurysm Kawasaki disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY ANEURYSM KAWASAKI DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital of Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, 201102, China

    Contact

    Contact

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