Coronary aneurysm

This trial is testing a new coronary extension catheter designed to help doctors deliver balloons and stents more easily during percutaneous coronary intervention (PCI) for coronary artery disease. The study will enroll about 69 adults who need PCI and for whom the catheter is pl…

This trial compares two blood thinners—rivaroxaban (Xarelto) and warfarin—in children over 2 years old who have giant coronary artery aneurysms caused by Kawasaki disease. The goal is to see if rivaroxaban is safer and as effective as warfarin at preventing blood clots, major ble…

This study looks at two different ways to use a heart-lung machine (ECMO) during high-risk heart procedures. One method sets up the machine just in case it's needed, while the other uses it from the start. The goal is to see which approach leads to fewer serious problems like dea…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal is to …

This registry is following 10,000 people who receive the BioFreedom Ultra stent, a device coated with the drug biolimus A9 to keep heart arteries open. The goal is to see how well the stent works in real-world patients, not just in controlled trials. Researchers will track proble…

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This pilot study tests the blood thinner Rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms after Kawasaki disease. The goal is to see if a specially adjusted dose can prevent new blood clots in the heart arteries while keeping bleeding risks low. Ch…

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study tests a new technology called IVUS-FFR that uses ultrasound images from inside heart arteries to quickly check if a blockage is serious enough to need a stent. Unlike the current standard test, it doesn't require an extra pressure wire or medication that can cause disc…

This study tests whether giving a set of nerve blocks (injections of numbing medicine) right after anesthesia but before surgery can reduce pain and the need for opioid painkillers after coronary artery bypass grafting. 56 adults scheduled for elective bypass surgery will be rand…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

This study looks back at the medical records of 1,000 people with coronary artery aneurysms—bulges in the heart's blood vessels. Researchers want to understand how these aneurysms change over time, what factors increase the risk of progression, and whether different treatment str…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study will follow 20,000 patients with complex coronary artery disease to see how non-fatal complications during a heart procedure (stent placement) affect their risk of death over the long term. Researchers aim to identify which complications are most dangerous. The study d…

This study tests two improvements for heart catheterization done through a small artery in the wrist. First, it checks if a special patch can stop bleeding faster. Second, it sees if using ultrasound to guide the needle makes the procedure more successful. About 480 adults needin…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This trial tests whether using a wrist artery access point closer to the hand (distal radial) is safer than the usual wrist access for complex heart procedures like opening blocked arteries. About 708 adults with stable or unstable heart conditions will be randomly assigned to on…

This study tests whether artificial intelligence can evaluate how well surgeons perform a key step in heart bypass surgery. Researchers will compare AI scores to those from human experts. The trial involves 284 patients undergoing bypass grafting and aims to see if AI can reliabl…