Children's Hospital Of Fudan University

This study tests whether Sanghe Jianghuo Granules, a traditional Chinese herbal medicine, can safely slow down early puberty in girls aged 5 to 8.5 years. The trial will involve 200 participants who will take the granules or a placebo twice daily for 3 months. The main goal is to…

This early-stage study tests a one-time gene therapy (CS-206) in 5 teenagers with severe sickle cell disease. The treatment uses the patient's own blood stem cells, modified with a gene-editing tool, to help produce healthy red blood cells. The goal is to reduce painful blockages…

This study tests the drug decitabine in 6 boys with XMEN disease, a rare genetic condition that weakens the immune system and damages the liver. The goal is to see if decitabine can improve liver function and immune cell activity. It is a very early, small trial focused on safety…

This study tests whether adding a traditional Chinese medicine herbal formula (Sanghe Jianghuo Granules) to standard Western treatment can better manage precocious puberty in girls aged 5 to 9. The goal is to slow down early breast development and bone aging, and improve final he…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study compares three blood purification methods in 120 children with sepsis, aged 29 days to 18 years. The goal is to see which method best reduces inflammatory chemicals and organ damage. Researchers will also check survival rates at 28 days.

This study will test a machine-assisted system that uses five simple behavioral tasks—like responding to their name or pointing—to screen toddlers for autism. Researchers will enroll 1,000 children aged 1.5 to 2.5 years, including those with autism, developmental delays, language…

This study tests a child-friendly breathing exercise program for children aged 6-18 recovering from severe pneumonia. The program is designed to be fun and engaging, aiming to improve recovery and make caregivers happier with the care. Researchers will compare kids who do the exe…

This study tests whether child life services—special support to help kids cope with medical procedures—can reduce pain and fear during skin prick allergy tests. About 140 children aged 1-18 will either receive this extra support or standard care. Researchers will measure pain, ho…

This study looks at a special nutrition plan for very premature babies (born before 32 weeks or weighing less than 3.3 pounds). The plan includes personalized breast milk feeding, extra zinc, and a nutrient called carnitine. Researchers want to see if this helps babies grow bette…

This study will see if a new set of guidelines for tube feeding helps critically ill children get better nutrition. About 500 children in intensive care units across several hospitals will take part. Nurses will follow the new standard, and researchers will check if it leads to f…

This study tests a new genetic method (mNGS) to quickly identify bacteria causing pneumonia in 400 children on breathing machines. Ventilator-associated pneumonia is a common and serious complication. By comparing mNGS results with standard lab tests, researchers hope to improve …

This study looks at how antibiotics are managed in the pediatric intensive care unit (PICU) for 1000 children. The goal is to see if better antibiotic practices can improve survival and shorten hospital stays. No new drugs are tested; instead, the research team will observe curre…