Children's Hospital Of Fudan University

This study looks at whether atorvastatin, a medicine usually used for high cholesterol, is safe and helpful for children with Kawasaki disease who also have heart artery issues. About 9 children will take atorvastatin along with standard treatments. Researchers will check for sid…

This early-stage study tests a new gene therapy called CS-206 for people with severe sickle cell disease. The treatment uses a patient's own blood stem cells, which are modified with a gene-editing tool to correct the disease. Five participants aged 12 to 18 will receive a single…

This early-stage trial tests whether adding a traditional Chinese medicine granule (Sanghe Jianghuo) to standard hormone therapy can better control early puberty in 100 girls aged 5-9. The goal is to slow down breast development and bone aging, and improve final height, while als…

This study compares different blood purification techniques to see which best reduces harmful inflammation in children with sepsis. About 120 children aged 29 days to 18 years with sepsis-related organ failure will be enrolled. The goal is to find a better way to lower inflammato…

This early study tests the safety and effectiveness of decitabine in 6 boys (ages 1 month to 18 years) with XMEN disease, a rare genetic condition that weakens the immune system and harms the liver. The drug aims to improve liver function and immune cell activity. The study is no…

This early-stage study will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus and scleroderma that haven't responded to other treatments. The goal is to see if the therapy is safe and can help control the disease. Childre…

This study will test whether a machine-assisted system can help screen toddlers for autism early. Researchers will compare the system's results with standard clinical diagnoses in 1,000 children aged 1.5 to 2.5 years. The goal is to see if the system can accurately tell apart aut…

This study looks at whether child life services—special support to help children cope with medical procedures—can make skin prick testing for allergies less painful and less scary for kids. About 140 children aged 1 to 18 will either get this extra support or standard care. Resea…

This study will test a new DNA-based method (mNGS) to identify the germs causing lung infections in 400 children who need a breathing machine. The goal is to see if this test is more accurate than standard lab cultures. If successful, it could help doctors choose the right antibi…

This study looks at how careful antibiotic use affects survival and recovery in 1,000 children admitted to the pediatric ICU for more than 48 hours. Researchers will track survival rates and length of stay to see if better antibiotic management improves outcomes. The goal is to f…

This study will see if a new set of guidelines for tube feeding helps critically ill children in intensive care get better nutrition. About 500 children and their nurses from multiple hospitals will take part. The goal is to make sure kids get the right amount of energy and that …

This study tests a set of nutrition best practices for very premature infants (born before 32 weeks or under 3.3 pounds). The goal is to see if personalized feeding, extra zinc, and carnitine can improve growth, organ health, and brain development. About 200 babies will take part…