Herbal granules aim to slow early puberty in young girls
NCT ID NCT07637019
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether Sanghe Jianghuo Granules, a traditional Chinese herbal medicine, can safely slow down early puberty in girls aged 5 to 8.5 years. The trial will involve 200 participants who will take the granules or a placebo twice daily for 3 months. The main goal is to see if breast development regresses, with secondary checks on hormone levels and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sanghe Jianghuo Granules (a traditional Chinese medicine blend of mulberry leaf, lotus leaf, rehmannia, anemarrhena, skullcap, and other herbs)
- What this could lead to
- If it works, this could offer a natural alternative to standard hormone therapy for early puberty, potentially with fewer side effects.
- What could go wrong
- This is an early-stage trial with only 200 participants, so results may not apply to all. The placebo group gets 10% active ingredient, which could blur the true effect. Also, the treatment is based on traditional Chinese medicine concepts, which may not be accepted globally.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Hospital of Shandong University of TCM
Jinan, Shandong, 250011, China
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Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, 210102, China
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The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, 510405, China
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The First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, Henan, 450000, China
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Xiamen Children's Hospital
Xiamen, Fujian, China
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