Ancient remedies take on early puberty: can herbs and needles slow it down?

NCT ID NCT06510764

Recruiting now Disease control Sponsor: Children's Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a combination of Chinese herbs (Ziyin-Xiehuo granules) and tiny acupuncture needles placed under the skin can help girls with idiopathic precocious puberty. The 170 participants will receive either the herbs plus acupuncture or a placebo. Researchers will check if breast tissue shrinks and if bone age progresses more slowly over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ziyin-Xiehuo Chinese medicine herbs and intradermal acupuncture
What this could lead to: If it works, this could offer a natural alternative to standard hormone therapy for managing early puberty in girls.
What could go wrong: This is a Phase 3 trial, but it's relatively small (170 participants) and uses traditional medicine, which may not work for everyone. The herbs and needles could cause mild side effects like skin irritation.

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Conditions

The condition(s) this trial relates to.

idiopathic central precocious puberty precocious puberty

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUPUNCTURE ALTERNATIVE MEDICINE PRECOCIOUS PUBERTY TREATMENT

Contacts and locations

Locations

Children's Hospital of Fudan University
RECRUITING

Shanghai, 201102, China
Children's Hospital of Fudan university
RECRUITING

Shanghai, Shanghai Municipality, 201102, China

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