Sleep hormone melatonin put to the test against lupus fatigue and inflammation
NCT ID NCT07721324
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial investigates whether taking melatonin before bed can improve sleep quality, reduce fatigue, and lower inflammation in adults with active lupus. Sixty-four participants will either receive standard care plus melatonin or standard care alone for 12 weeks. Researchers will measure changes in blood markers of inflammation and oxidative stress, as well as sleep and quality of life scores.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- melatonin, a hormone that regulates sleep, given as an oral tablet (15 mg/day) for 12 weeks
- What this could lead to
- If it works, melatonin could become a simple, low-cost way to improve sleep, reduce fatigue, and lower inflammation in people with lupus.
- What could go wrong
- This is a small, early-stage trial. Melatonin may not significantly affect lupus symptoms or inflammation, and side effects like drowsiness or dizziness are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Rheumatology Ain Shams University hospitals
Cairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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