Saline wash may offer safer way to treat lung infections

NCT ID NCT07666464

Recruiting now Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether early irrigation of the chest cavity with saline can improve outcomes for people with complicated pleural infections. 244 adults will receive either standard care or saline irrigation twice daily for three days. The goal is to see if this approach reduces death, the need for surgery, or additional enzyme therapy within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: saline (0.9% sodium chloride) irrigation
What this could lead to: If successful, this could offer a safer, simpler alternative to enzyme therapy for treating complicated pleural infections, reducing the need for surgery or additional treatments.
What could go wrong: This is a single trial with 244 participants, and earlier evidence is limited to one small study. The saline irrigation may not prove more effective than standard care, and there is a risk of adverse events like bleeding or infection.

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Conditions

The condition(s) this trial relates to.

pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLEURAL INFECTIONS THERAPY

Contacts and locations

Locations

CHU Amiens Picardie
RECRUITING

Amiens, Picardie, 80054, France

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