One infusion may keep childhood kidney disease at bay — a trial puts it to the test

NCT ID NCT07765914

Not yet recruiting Disease control Sponsor: Children's Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether adding a single infusion of zuberitamab to standard steroid therapy can help children aged 1 to 18 with newly diagnosed steroid-sensitive nephrotic syndrome stay relapse-free longer. Participants receive either standard steroids alone or steroids plus zuberitamab, and are followed for up to 12 months with daily urine tests and regular checkups. The study aims to see if the extra treatment improves disease control and to assess its safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zuberitamab (a biologic given as a single intravenous infusion)
What this could lead to: If it works, adding zuberitamab to standard steroids could help children with nephrotic syndrome avoid relapses and reduce the need for repeated steroid courses.
What could go wrong: This is an early-phase trial with a limited number of participants, so results may not apply to all children. Zuberitamab can cause infusion reactions and may increase infection risk, requiring preventive antibiotics.

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Conditions

The condition(s) this trial relates to.

nephrotic syndrome nephrotic syndrome of childhood - steroid sensitive idiopathic steroid-sensitive nephrotic syndrome prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEPHROTIC SYNDROME

Contacts and locations

Locations

Children's Hospital of Fudan University

Shanghai, Shanghai Municipality, China
Guiyang Maternal and Child Health Care Hospital

Guiyang, China
Second Xiangya Hospital of Central South University

Changsha, China
Shanghai Children's Hospital

Shanghai, China
Shanghai Children's Medical Center

Shanghai, China
Wuhan Children's Hospital

Wuhan, China
Wuxi Women's & Children's Hospital

Wuxi, China
Xiamen Maternity & Child Care Hospital

Xiamen, China
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, China

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