Could less steroid be just as good for kids with kidney disease?
NCT ID NCT06635720
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a lower dose of the steroid prednisone can treat relapses of nephrotic syndrome in children as effectively as the standard dose. Fifty children aged 1 to 18 with active relapses will be randomly assigned to either the reduced-dose or standard-dose regimen. The goal is to see if this approach is feasible and safe, potentially leading to fewer steroid side effects in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prednisone (steroid)
What this could lead to
If successful, this could lead to a safer, lower-dose steroid regimen for children with nephrotic syndrome, reducing side effects while maintaining disease control.
What could go wrong
This is a small pilot study (50 children) at one hospital, so results may not apply broadly. The lower dose might be less effective at controlling relapses.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Hospital for Sick Children
Toronto, Ontario, M5G 1E8, Canada