Can a single Immune-Targeting drug quiet an autoimmune kidney disease?
NCT ID NCT05914155
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether rituximab, an infusion drug that calms certain immune cells, can help people with idiopathic membranous nephropathy and nephrotic syndrome. Participants receive either rituximab or a placebo, and the study tracks how many achieve a significant reduction in urine protein, a key sign of kidney improvement. The goal is to see if this treatment can offer a safer, steroid-free way to manage the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- rituximab (an infusion drug that targets certain immune cells)
- What this could lead to
- If successful, rituximab could become a steroid-free option to help people with this kidney disease achieve remission and avoid progression to kidney failure.
- What could go wrong
- This is a phase 3 trial, but results are not guaranteed. Rituximab can have side effects like infusion reactions and increased infection risk, and not all patients may respond.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anjo Kosei Hospital
Anjo, Aichi-ken, 4468602, Japan
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Asahikawa Medical University Hospital
Asahikawa, Hokkaido, 0788510, Japan
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Fujita Health University hospital
Toyoake, Aichi-ken, 4701192, Japan
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Hamamatsu University Hosptial
Hamamatsu, Shizuoka, 4313129, Japan
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Juntendo University Urayasu Hospital
Urayasu, Chiba, 2790021, Japan
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Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 9208641, Japan
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Kasugai Municipal Hospital
Kasugai, Aichi-ken, 486-8510, Japan
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Konan Kosei Hospital
Kōnan, Aichi-ken, 4838704, Japan
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Kumamoto University Hospital
Kumamoto, Kumamoto, 8608556, Japan
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Kurume University Hospial
Kurume, Fukuoka, 8300011, Japan
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Kyoto University Hospital
Kyoto, Kyoto, 6068507, Japan
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Kyushu University Hospital
Fukuoka, Fukuoka, 8128582, Japan
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Mie University Hospial
Tsu, Mie-ken, 5148507, Japan
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Nagoya University Hospital
Nagoya, Aichi-ken, 4668560, Japan
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Osaka University Hospital
Osaka, Osaka, 5650871, Japan
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Tazuke Kofukai, Medical Research Institute, Kitano Hospital
Osaka, Osaka, 5308480, Japan
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Tohoku University Hospital
Sendai, Miyagi, 9808574, Japan
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University Hospital,Kyoto Prefectural University of Medicine
Kyoto, Kyoto, 6028566, Japan
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