Children's Hospital Of Fudan University

This study tested whether a moisturizer containing postbiotics (beneficial yeast and bacteria) can lower the chance of eczema returning in children aged 0-6 years whose skin had cleared up. 98 children used either the special moisturizer or a regular one. The goal was to see if t…

This study tested a new treatment for β-thalassemia major, a severe blood disorder that requires lifelong blood transfusions. Two children received their own stem cells that were gene-edited in a lab to produce healthier red blood cells. The goal was to see if the treatment is sa…

This study looked at whether atorvastatin, a common cholesterol medicine, is safe and can reduce skin bumps called xanthomas in children with Alagille syndrome. Fifteen children aged 0-17 with high cholesterol and skin bumps took the drug for 6 months. Doctors checked if the bump…

This study looked at whether adding a steroid called prednisolone to the usual treatment (immunoglobulin and aspirin) could reduce damage to the heart's arteries in children with Kawasaki disease. Over 3,200 children were enrolled. The main goal was to see if fewer children devel…

This early-phase study tested an engineered probiotic (CBT102-A) in 15 children aged 3–17 with phenylketonuria (PKU), a genetic condition that makes it hard to break down an amino acid called phenylalanine. For 20 days, 10 children received the probiotic and 5 received a placebo.…

This study looked at whether hydroxychloroquine can help children with a rare genetic lung condition that affects surfactant, a substance that keeps lungs open. 25 children took the drug, and doctors checked if their oxygen needs improved over 6 months. The goal was to see if the…

This study tested a digital game-based therapy to improve attention in 40 children aged 8-12 with ADHD. The therapy used multitask games designed to boost focus and control, compared to a simpler grid game. Researchers measured changes in attention and ADHD symptoms to see if the…

This small study tested a drug called esketamine in 3 girls with Rett syndrome, a rare genetic disorder that affects development and movement. The goal was to see if weekly infusions over five weeks could improve symptoms and be safe. The trial is complete, but results are not ye…

This study followed 487 mothers and their babies to see if key nutrients like folate and vitamin D during early pregnancy are linked to eczema (atopic dermatitis) in infants up to 6 months old. Researchers measured nutrient levels in the mothers' blood and checked babies for ecze…

This study gathered information from 271 children in China with a rare lung condition called childhood interstitial lung disease (chILD). Researchers collected genetic and medical data to create a database and biobank, aiming to better understand the causes and features of the di…

This study looked at 800 children who survived blood cancer to see if having a congenital heart defect raises their risk of death or other health problems later in life. Researchers also checked for shared genes between the two conditions. The goal is to better understand and car…

This study looked at 346 children who needed a breathing machine (ventilator) for a long time. Researchers recorded the reasons they needed it, such as nerve or muscle diseases, airway problems, or brain conditions. They also tracked how long children stayed on the ventilator and…