Children's Hospital Of Fudan University

This early-stage study tested a new gene-edited stem cell transplant in 2 children with severe β-thalassemia, a serious blood disorder requiring lifelong transfusions. The treatment aims to help the body produce healthy red blood cells and reduce or stop the need for transfusions…

This study looked at whether adding a steroid called prednisolone to the usual treatment (immunoglobulin and aspirin) could reduce heart artery damage in children with Kawasaki disease. Over 3,200 children took part. The goal was to see if the combination therapy lowers the chanc…

This study tested whether a moisturizer containing postbiotic Saccharomyces and Lactobacillus can reduce the risk of eczema returning in children aged 0-6 years who are in remission. 98 children used either the special emollient or a standard one for 12 weeks. The goal was to see…

This study tested the safety and effectiveness of atorvastatin (Lipitor) in 15 children with Alagille syndrome who had skin cholesterol deposits called xanthomas. The children took the drug for 6 months, and doctors graded the size and number of the lumps. The goal was to see if …

This study looked at whether hydroxychloroquine, a medicine used for malaria and autoimmune conditions, can help children with a rare genetic lung disease that affects the lungs' natural cleaning fluid. 25 children took the drug, and researchers checked if their need for extra ox…

This study tested an engineered probiotic called CBT102-A in 15 children with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. The children took the probiotic or a placebo for 20 days. The goal was to see if the probiotic cou…

This early study tested esketamine, a form of ketamine, in 3 girls with Rett syndrome. The goal was to see if weekly infusions over five weeks could improve symptoms and be safe. The trial is complete, but with only 3 participants, it's too small to draw firm conclusions.

This study tested whether playing a specially designed multitask game for 25 minutes a day, at least 5 days a week, could improve attention in children aged 8-12 with ADHD. Forty children participated, and researchers measured changes in attention using a computer test called TOV…

This study looked at 346 children who needed a breathing machine (ventilator) for a long time. Researchers recorded the reasons they needed it, such as nerve or muscle diseases, airway problems, or brain conditions. They also tracked how long the children stayed on the ventilator…

This study looked at 271 children in China with a rare lung condition called childhood interstitial lung disease (chILD). Researchers collected medical information and genetic samples to find out what causes the disease. The goal was to create a database and biobank to help docto…

This study followed 487 pregnant women in Shanghai to see if key nutrients like folate and vitamin D affect the chance of their baby developing eczema (atopic dermatitis) by 6 months old. Researchers measured nutrient levels in the mothers' blood and checked babies for eczema usi…

This completed study looked at 800 children who survived blood cancer to see if having a congenital heart defect raises their risk of death or other health problems later in life. Researchers also checked for shared genetic links between the two conditions. The goal is to better …