Could a probiotic pill help kids with PKU?
NCT ID NCT05948020
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an engineered probiotic called CBT102-A in 15 children with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. The children took the probiotic or a placebo for 20 days. The goal was to see if the probiotic could safely lower blood phenylalanine levels, potentially easing the need for a strict diet.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
engineered probiotic (CBT102-A)
What this could lead to
If it works, this could offer a new way to manage PKU by helping the body break down phenylalanine without a strict diet.
What could go wrong
This is a very early, small trial (15 children) testing safety and short-term effects. The probiotic may not lower phenylalanine enough or could cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Fudan University
Shanghai, China