Could a probiotic pill help kids with PKU?
NCT ID NCT05948020
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an engineered probiotic called CBT102-A in 15 children with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. The children took the probiotic or a placebo for 20 days. The goal was to see if the probiotic could safely lower blood phenylalanine levels, potentially easing the need for a strict diet.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- engineered probiotic (CBT102-A)
- What this could lead to
- If it works, this could offer a new way to manage PKU by helping the body break down phenylalanine without a strict diet.
- What could go wrong
- This is a very early, small trial (15 children) testing safety and short-term effects. The probiotic may not lower phenylalanine enough or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Fudan University
Shanghai, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a PKU diet reshape the gut microbiome? a study investigates
- Study aims to tailor PKU drug dosing for patients with organ impairment
- Hidden eating disorders may affect PKU patients on strict diets
- New pill could tame phenylketonuria by blocking amino acid absorption
- PKU diagnosis: a study on breaking the news to families
- New pill for PKU shows promise in early human testing