Could daily antibiotics shield babies from Post-Surgery infections?

NCT ID NCT05925309

Recruiting now Disease control Sponsor: Children's Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving oral antibiotics after Kasai surgery can prevent cholangitis, a serious bile duct infection, in infants with biliary atresia. About 356 babies will be randomly assigned to receive either preventive antibiotics or standard care, and they will be followed for two years. The goal is to see if the antibiotics reduce infection rates without causing major side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral antibiotics (prophylactic)
What this could lead to: If it works, this could show that preventive antibiotics lower the risk of serious bile duct infections after Kasai surgery, improving outcomes for babies with biliary atresia.
What could go wrong: This is an early-stage trial with no phase designation, and the results may not apply to all patients. Antibiotics can cause side effects like diarrhea or resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary atresia cholangitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTI-BACTERIAL AGENTS BILIARY ATRESIA CHOLANGITIS

Contacts and locations

Locations

Children's Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 201102, China

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