Matching depression treatment to your symptoms: a smarter approach?

NCT ID NCT06580041

ENROLLING_BY_INVITATION Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matched to their symptom profile, including medications like pramipexole or behavioral therapies. The goal is to see if personalized treatment leads to greater improvement in depressive symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pramipexole, methylphenidate, phenelzine, mindfulness-based stress sensitivity therapy, complicated grief treatment
What this could lead to: If successful, this could show that choosing treatments based on a person's specific depression symptoms leads to better outcomes than standard trial-and-error approaches.
What could go wrong: This is a relatively small, early-phase study (150 people) at a single site, so results may not apply to everyone. The approach may not prove superior to usual care, and some medications have side effects.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSIVE DISORDER, MAJOR MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Nancy Friend Pritzker Psychiatry Building, University of California, San Francisco

San Francisco, California, 94107, United States

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