Matching depression treatment to your symptoms: a smarter approach?
NCT ID NCT06580041
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matched to their symptom profile, including medications like pramipexole or behavioral therapies. The goal is to see if personalized treatment leads to greater improvement in depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pramipexole, methylphenidate, phenelzine, mindfulness-based stress sensitivity therapy, complicated grief treatment
What this could lead to
If successful, this could show that choosing treatments based on a person's specific depression symptoms leads to better outcomes than standard trial-and-error approaches.
What could go wrong
This is a relatively small, early-phase study (150 people) at a single site, so results may not apply to everyone. The approach may not prove superior to usual care, and some medications have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Nancy Friend Pritzker Psychiatry Building, University of California, San Francisco
San Francisco, California, 94107, United States