Brain scans may reveal who benefits from depression therapy

NCT ID NCT04581902

Recruiting now Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to find brain-based markers that can predict how well people with major depression respond to repetitive transcranial magnetic stimulation (rTMS) therapy. Researchers will use MRI and EEG to track brain changes in 50 adults with moderate to severe depression who have not responded well to medication. The goal is to improve diagnosis and personalize treatment for depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS)
What this could lead to: If successful, this could help doctors predict which patients will benefit from TMS therapy for depression, making treatment more personalized.
What could go wrong: This is a small, early-stage study focused on finding biomarkers, not testing a new treatment. The results may not apply to all patients or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE DISORDER, MAJOR

Contacts and locations

Locations

University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

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