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Can a ketamine nasal spray quickly ease severe depression in suicidal teens?

NCT ID NCT07227454

Recruiting now Symptom relief Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests whether a nasal spray containing esketamine, given alongside standard care, can rapidly reduce symptoms of major depression and suicidal thoughts in adolescents. About 258 teens with acute suicidal ideation or behavior will receive either esketamine or a psychoactive placebo. The main goal is to see if depression scores improve within 24 hours and last through 25 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Esketamine (a nasal spray form of ketamine)
What this could lead to
If it works, this could provide a fast-acting option to ease severe depression and suicidal thoughts in teenagers, potentially saving lives during a crisis.
What could go wrong
This is a Phase 3 trial, but it's still experimental. Esketamine can cause side effects like dizziness, nausea, or dissociation. The placebo used is a psychoactive drug (midazolam), which may complicate results. Success is not guaranteed.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE DISORDER, MAJOR

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AOU Meyer

    RECRUITING

    Florence, 50134, Italy

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, 80131, Italy

  • Azienda Ospedaliera Universitaria Policlinico Riuniti di Foggia

    RECRUITING

    Foggia, 71122, Italy

  • Azienda Ospedaliero Universitaria di Sassari

    RECRUITING

    Sassari, 07100, Italy

  • Bradley Hospital

    RECRUITING

    East Providence, Rhode Island, 02915, United States

  • Centro Integrado Facili

    RECRUITING

    São Bernardo do Campo, 09726 150, Brazil

  • Clinica Univ. de Navarra

    RECRUITING

    Pamplona, 31008, Spain

  • Debreceni Egyetem Klinikai Kozpont

    RECRUITING

    Debrecen, 4031, Hungary

  • Endeavor Health Evanston Hospital

    RECRUITING

    Evanston, Illinois, 60201, United States

  • Fundacao Faculdade de Medicina Hospital da Clinicas da Faculdade de Medicina de Sao Paulo

    RECRUITING

    São Paulo, 05403 010, Brazil

  • Fundacio Althaia Xarxa Assistencial Universitaria de Manresa

    RECRUITING

    Manresa, 08243, Spain

  • Hosp. Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hosp. Sant Joan de Deu

    RECRUITING

    Esplugues de Llobregat, 08950, Spain

  • Hosp. Univ. Central de Asturias

    RECRUITING

    Oviedo, 33011, Spain

  • Hosp.Univ.Parc Tauli

    RECRUITING

    Sabadell, 08208, Spain

  • Instituto Apice

    RECRUITING

    Salvador, 40170 108, Brazil

  • Instituto de Pesquisa Pensi Sandra Mutarelli Setubal

    RECRUITING

    São Paulo, 01 227 200, Brazil

  • John S Dunn Behavioral Sciences Center at UTHealth Houston

    RECRUITING

    Houston, Texas, 77021, United States

  • Mackay Memorial Hospital Tamsui Branch

    RECRUITING

    New Taipei City, 251, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100, Taiwan

  • Peachford Hospital-Atlanta Behavioral Research

    RECRUITING

    Atlanta, Georgia, 30338, United States

  • Petz Aladar Megyei Oktato Korhaz

    RECRUITING

    Győr, 9023, Hungary

  • Presidio Ospedaliero Santa Marta e Santa Venera

    RECRUITING

    Acireale, 95024, Italy

  • Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose

    RECRUITING

    Criciúma, 88811 000, Brazil

  • Szegedi Tudomanyegyetem

    RECRUITING

    Szeged, 6720, Hungary

  • Taipei Medical University Hospital

    RECRUITING

    Taipei, 110, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 112, Taiwan

  • Tri-Service General Hospital

    RECRUITING

    Taipei, 114, Taiwan

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of Cincinnati

    RECRUITING

    Cincinnati, Ohio, 45219, United States

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