Esketamine vs. ECT: a new hope for suicidal depression?
NCT ID NCT06355180
First seen Oct 31, 2025 · Last updated Jun 19, 2026 · Updated 35 times
Summary
This study tested whether esketamine, a fast-acting antidepressant, works as well as electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression or bipolar disorder. 340 adults received either esketamine infusions or ECT over two weeks. The main goal was to see how many people no longer had significant suicidal thoughts after treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beijing Anding Hospital
Beijing, Beijing Municipality, 100088, China
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Beijing Chaoyang District Third Hospital
Beijing, China
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Beijing Daxing District Xinkang Hospital
Beijing, China
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Inner Mongolia Autonomous Region Mental Health Center
Hohhot, China
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The Second People's Hospital of Dali Bai Autonomous Prefecture
Dali, China
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Wuhu Fourth People's Hospital
Wuhu, Anhui, 241002, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Esketamine
What this could lead to
If esketamine works as well as ECT, it could offer a faster, less invasive option to reduce suicidal thoughts in people with depression.
What could go wrong
This is a non-inferiority trial, so esketamine may not be better than ECT. Results are preliminary and need confirmation in larger, longer studies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.