Rewiring the brain: could neurofeedback break the loop of suicidal thoughts?

NCT ID NCT06481033

Completed Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linked to rumination while receiving real-time feedback. The study primarily assesses feasibility and acceptability, with secondary measures tracking changes in rumination and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Real-time fMRI neurofeedback, a brain-training technique that shows veterans their own brain activity in real time to help them learn to control regions linked to rumination.
What this could lead to: If successful, this could lead to a new, non-invasive therapy that helps veterans break the cycle of repetitive suicidal thoughts, potentially reducing suicide risk.
What could go wrong: This is a small pilot study focused on feasibility, not proof of effectiveness. The technique may not work for everyone, and benefits might not last beyond the training sessions.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder mood disorder Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MOOD DISORDERS SUICIDE

Contacts and locations

Locations

James J. Peters VA Medical Center, Bronx, NY

The Bronx, New York, 10468-3904, United States

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