Can rewriting bad memories ease depression? small study tests new therapy in GP offices

NCT ID NCT07362511

Recruiting now Symptom relief Sponsor: University of Amsterdam Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a therapy called Imagery Rescripting (ImRs) can help reduce depressive symptoms when delivered by mental health assistants in primary care. Twelve adults with depression will wait 2-4 weeks, then receive 5 sessions of ImRs over 10 weeks, where they work with a therapist to change negative memories into more positive ones. Researchers will measure changes in depression severity, self-esteem, and core beliefs up to six months after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Imagery Rescripting (ImRs) - a therapy where patients change negative memories into more positive ones with a therapist's help
What this could lead to: If it works, this could offer a brief, accessible therapy for depression within primary care, reducing the need for specialist referrals.
What could go wrong: This is a very small early study with only 12 participants, no control group, and no blinding, so results may not apply broadly. The therapy may not work for everyone or effects may not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW SELF-ESTEEM MAJOR DEPRESSIVE DIORDER MOOD DISORDERS

Contacts and locations

Locations

UvA Huisartsen
RECRUITING

Amsterdam, North Holland, 1018VZ, Netherlands

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