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Magic mushroom compound may offer new hope for stubborn depression

NCT ID NCT06341426

Ongoing Disease control Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Researchers will measure changes in depression symptoms, safety, and quality of life to see if a second dose adds any benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
psilocybin
What this could lead to
If successful, this could point toward a new treatment option for people with depression that hasn't responded to standard medications.
What could go wrong
This is an early-phase trial with only 92 participants, so results may not apply to everyone. Psilocybin can cause intense psychological experiences and side effects, and the long-term benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Depressive Disorder, Treatment-Resistant major depressive disorder mood disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MAJOR DEPRESSIVE DISORDER MOOD DISORDERS TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

  • Centre for Addiction and Mental Health (CAMH)

    Toronto, Ontario, M6J 1H4, Canada

  • Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

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