Reading the Brain's signals to predict who benefits from deep brain stimulation
NCT ID NCT06813300
First seen Sep 18, 2026 · Last updated Sep 18, 2026
Summary
Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive and movement tasks before, during, and after their deep brain stimulation procedure. Researchers compare those recordings with symptom scores to look for brain-activity patterns that predict how well the stimulation works.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- electrophysiological recordings of brain activity during cognitive tasks
- What this could lead to
- If researchers can link specific brain-activity patterns to how well deep brain stimulation works, doctors could tune the therapy faster and more precisely for each patient.
- What could go wrong
- The study observes brain signals rather than testing a new treatment, so it may not find reliable biomarkers. Results from a single group of patients may not apply broadly, and recording brain activity during surgery carries the usual risks of the procedure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 250 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2024
- Expected to finish
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Apr 2036
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patient * Patient suffering from a pathology requiring treatment with deep brain stimulation: neurological disease (e.g.: Parkinson Disease, Essential Tremors, dystonia, epilepsy, etc.) or psychiatric disease (e.g.: Obsessive Compulsive Disorder, depression, eating disorders, etc.). * Patient capable of understanding the study procedures and completing the self-questionnaires in French * Patient informed and having signed the informed consent form Exclusion Criteria: * Contraindications to DBS, neurosurgery or anesthesia * Patients with significant hemorrhagic or infectious risks * Patient unable to perform the neurocognitive or sensorimotor tests * Patient who is not a beneficiary of a social security system.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Grenoble-Alpes Hospital Center
NOT_YET_RECRUITINGGrenoble, 38043, France
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Groupe Hospitalo-Universitaire Paris Psychiatrie et Neurosciences, Paris
RECRUITINGParis, 75014, France
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