Mindfulness training may ward off psychosis in At-Risk students

NCT ID NCT06929442

Recruiting now Prevention Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The goal is to see if teaching mindfulness, self-compassion, and mentalization reduces delusions, anxiety, and depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Resilience Training (mindfulness, self-compassion, mentalization skills)
What this could lead to: If it works, this could point toward a simple, non-drug way to reduce the risk of developing serious mental illness in young adults.
What could go wrong: This is an early-stage trial with only 192 participants, so results may not apply to everyone. The intervention is short (4 weeks) and may not have lasting effects.

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Conditions

The condition(s) this trial relates to.

anxiety disorder mood disorder psychotic disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DISORDERS MOOD DISORDERS PSYCHOTIC DISORDERS

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Charlestown, Massachusetts, 02129, United States

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