ANXIETY DISORDERS

This study is testing whether adding a digital mindfulness program to regular medical care helps adults with emotional disorders like depression or anxiety recover faster and stay better over two years. Researchers will compare people who get the mindfulness program plus their us…

This study is testing whether a new computer-based therapy can make standard talk therapy more effective for children and teens with anxiety. The new therapy uses music that plays when a child looks at faces on a screen, aiming to retrain attention patterns. Researchers will comp…

This study is testing if adding a common antidepressant (fluoxetine) to standard immunotherapy helps people with advanced liver or gallbladder cancer who also have depression or anxiety. Researchers want to see if the combination works better at shrinking tumors and helping patie…

This study is testing if a non-invasive brain stimulation treatment called TMS can help reduce symptoms of anxiety and depression in children and teenagers. It will involve 120 young people aged 6 to 18 who have been diagnosed with these conditions. The goal is to see if this dru…

This large study is testing whether using a person's genetic information can help doctors prescribe psychiatric medications more effectively. It will compare standard prescribing against a method that uses genetic test results to guide drug choice and dosage. The goal is to see i…

This study is testing whether adding an FDA-approved CBD medication to standard talk therapy (CBT) helps adults with generalized anxiety disorder. Researchers will use brain scans to see if CBD helps the brain better control emotions during treatment. About 90 participants aged 1…

This study is testing whether a special computer-based brain training program can help people with anxiety, depression, or PTSD. Participants will be randomly assigned to use either the active training program or a less effective 'sham' version. Researchers will measure changes i…

This study is testing a group therapy program called Resilience Training for Teens that aims to prevent high school students with mild emotional symptoms from developing serious mental illnesses. Researchers will work with 70 teens aged 14-19 who are experiencing early signs of d…

This study is testing whether short, self-guided online programs can teach parents skills to better manage anxiety in their young children (ages 2-7). Researchers will randomly assign 90 parents to one of three educational programs and track changes over 8 months. The goal is to …

This study is testing a brief, free online program designed to help caregivers of children with anxiety. The 30-minute session teaches skills to better support anxious children and reduce family stress. Researchers are adapting the program for Latin, Haitian, and Haitian-American…

This study is testing whether a single session combining a non-invasive brain stimulation technique (rTMS) with training in emotion regulation skills can help people who struggle to calm down when upset. Researchers want to see if this combined approach changes brain activity and…

This study is testing different versions of a short, one-hour online program designed to help people manage symptoms of depression and anxiety while they wait for a regular therapy appointment. Researchers will compare eight different versions of the program to see which combinat…

This study is testing a brief program called Omnis Salutis, designed to help recent Veterans with conditions like PTSD, depression, anxiety, or substance use. The program involves three sessions where Veterans learn to communicate their health goals to doctors and loved ones. Res…

This study is testing a short-term group talk therapy designed to help people with anxiety or depression. It will compare this new therapy to a standard group therapy to see which is more effective at reducing symptoms. The study aims to enroll 100 adults from community mental he…

This study is testing whether intensive, condensed versions of cognitive-behavioral therapy (CBT) can help veterans and service members with PTSD and anxiety disorders. Researchers are comparing two different delivery methods—individual sessions over two weeks versus group sessio…

This study is testing a specially adapted self-help workbook to see if it can help reduce symptoms of anxiety and depression for people in prison. About 96 participants will work through the 8-week workbook on their own, with researchers checking in to see if it's helpful and pra…

This study is testing a 4-week mindfulness program designed to help new mothers experiencing anxiety after childbirth. It aims to reduce anxiety symptoms while also improving emotional control and body awareness. Researchers will use questionnaires and brain scans to measure chan…

This study tests two ways to help people with a fear of spiders. One group does a live therapy session with a real spider, another watches a therapy session over video chat, and a third group waits. Researchers will measure changes in fear, disgust, and willingness to approach sp…

This study is testing a new online therapy program called DINOSAUR, designed to help reduce anxiety in young children (ages 4-6) who have autism. The program uses a form of talk therapy adapted for kids with autism and is delivered to families over video calls. Researchers want t…

This study is testing a new sensory tool called the HealPod to help teens in juvenile detention manage difficult emotions like anger and anxiety. The pod uses sound, gentle vibrations, and light during a 5-minute session, followed by journaling and therapy. Researchers want to se…

This is a small pilot study to see if a culturally adapted talk therapy is practical and acceptable for people living with HIV who also have depression and anxiety in Pakistan. Fifty participants will be randomly assigned to either receive six sessions of this special therapy or …

This study is testing a smartphone app designed to help people recover from knee or hip replacement surgery. The app uses digital therapy techniques and coach support to help patients manage anxiety, depression, and pain. Researchers want to see if using the app can help patients…

This study is testing whether two types of exercise training—Qigong (a gentle mind-body practice) and a mixed exercise program—can help people with panic disorder. Researchers want to see if these activities can reduce anxiety and panic attacks while also improving balance, stren…

This study aims to understand how a non-invasive brain stimulation device (rTMS) might change how people with anxiety disorders react to and cope with fearful situations. Researchers are recruiting 80 adults currently in treatment for anxiety to measure brain activity, heart rate…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This study is testing whether an artificial intelligence (AI) tool can reliably measure the severity of depression and anxiety in adults. Researchers will compare the AI's analysis of video interviews to assessments made by human clinicians. The goal is to see if AI can provide c…

This study aims to understand how anxiety affects the developing brain in children and teenagers. Researchers will use brain scans and thinking tasks to compare youth with anxiety disorders to healthy youth, both before and after they receive standard treatments like therapy or m…

This study aims to see if brain scans can better predict how well a person will respond to online therapy for depression, social anxiety, or insomnia, compared to just asking them. Researchers will scan the brains of 150 people before they start a 12-week online therapy program. …

This study aims to find genetic markers that can predict which children and young adults might experience a troubling side effect called 'behavioral activation' from common antidepressant medications (SSRIs). Researchers will compare the DNA of 160 young people (ages 6-24) who ei…

This study aims to understand how the brain processes fear and threat in people with depression, anxiety, or both. Researchers will give 165 participants a single dose of an anxiety medication (or a placebo) and use brain scans and eye-blink tests to measure their fear responses.…

This study aims to develop better brain scanning techniques to understand mood and anxiety disorders like depression. Researchers will use MRI scans and thinking tests to compare brain structure and activity in 300 healthy volunteers and 90 people with major depression. The goal …

This study is investigating whether a non-invasive technology called transcranial focused ultrasound (tFUS) can temporarily change activity in deep brain areas involved in anxiety. Researchers are recruiting 40 people who recently started treatment for anxiety to complete tasks a…