ANXIETY DISORDERS

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can improve tumor control and survival in 240 people with advanced liver or gallbladder cancer who also have depression or anxiety. Participants will receive either fluoxetine or a pl…

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to support their teen's mental health. Researchers will see if the program is practical and helpful for families.

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether an AI-guided cognitive behavioral therapy program can reduce symptoms of mild depression and anxiety in adults. Over 10 weeks, 120 participants will either receive AI-guided therapy through a digital platform or standard care. The goal is to see if AI can…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study tests if a smartphone app called Sidekick can help teenagers with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens aged 13-18 will use the app alongside their usual outpatient treatment. The goal is to see if the app is practical, …

This study tests a new telehealth program called DINOSAUR to help young children (ages 4 to 6) with autism who also have anxiety. The program teaches children and their parents strategies to reduce worry and handle uncertainty. About 70 children will take part in this 14-week onl…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a brain-training technique called neurofeedback can help people with both heart disease and anxiety control their heart rate during stress. 56 adults will either receive real or fake (sham) neurofeedback while their brain activity and heart rate are measu…

This study tests whether a non-invasive brain-training technique called neurofeedback can help people with both coronary heart disease and anxiety. Participants will learn to control a part of their brain linked to stress, using real-time feedback from a headband. The goal is to …

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study is testing whether adding a low or moderate dose of FDA-approved cannabidiol (Epidiolex) to cognitive behavioral therapy (CBT) helps adults with generalized anxiety disorder more than CBT plus a placebo. Researchers will measure changes in brain activity related to emo…

This study compares two types of exposure training for people with spider phobia: in-person exposure with a real spider and videochat-based exposure where someone else handles the spider. 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting…

This study looks at whether qigong or multicomponent exercise training can improve physical and mental health in people with panic disorder. Researchers will enroll 60 adults diagnosed with panic disorder and have them do 8 weeks of exercise. The goal is to see if these activitie…

This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The …

This study is testing whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will track symptom changes using questionnaires. The goal is to see if th…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests a short, 30-minute online program for caregivers of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers want to see if it reduces caregiver anxiety and helps them better support their child.

This study tests a 4-week mindfulness program designed specifically for new mothers and birthing parents with clinical anxiety. Researchers will measure changes in anxiety, emotion regulation, and body awareness using questionnaires and brain scans. The goal is to see if this min…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study tests a computer program called COGENT, designed to improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults will be randomly assigned to either the COGENT training or a sham program. Researchers will compare changes in …

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

This study explores whether a non-invasive brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also suffer from anxiety. Fifty-five women will receive six different intensities of stimulation while their heart rate…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study looks at how exercise affects brain markers linked to anxiety. Thirty adults with anxiety disorders will follow a 4-week virtual exercise program. Researchers will measure specific brain chemicals from blood samples to understand the biological changes behind exercise'…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study is testing whether an AI tool can accurately measure depression and anxiety symptoms from video interviews. Researchers will compare the AI's ratings to those of human clinicians. The goal is to create a more consistent way to evaluate symptoms in clinical trials, whic…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants …