ANXIETY DISORDERS

This study looks at whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help shrink tumors and extend survival in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 participants will be randomly assigned…

This study tests whether using a person's genetic information to choose psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with depression, anxiety, or psychotic disorders will receive either genetically tailored treatment or usual care…

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study tests whether adding a computer-based music therapy (GCMRT) to standard talk therapy (CBT) works better than CBT alone for children aged 8-17 with anxiety disorders. About 150 participants will receive weekly CBT for 4 weeks, then 8 weeks of CBT plus either GCMRT or a …

This study tests a short-term group therapy designed to help people with anxiety and depression. One hundred adults will be randomly assigned to receive either this new therapy or the usual group therapy. Researchers will measure changes in anxiety and depression symptoms after t…

This study tests a non-invasive brain stimulation technique called rTMS to see if it can reduce anxiety and improve heart function in women who have had multiple miscarriages and struggle with anxiety. Researchers will use a magnetic coil on the scalp to gently stimulate a brain …

This study compares two intensive formats of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format best reduc…

This study tests a brain-training technique called neurofeedback in 56 adults with stable heart disease and anxiety. Participants learn to control a brain region linked to stress while exposed to cold pain. The goal is to see if real training lowers heart rate more than a sham ve…

This study tests a therapy called SoundHeal for teens in juvenile detention who struggle with emotions like anger and anxiety. About 12 youth aged 12-18 will sit in a special pod with calming sounds, music, gentle vibrations, and soft light, then write about their experience. The…

This study tests whether a telemedicine-delivered cognitive behavioral program (RxWell) can help patients use fewer opioid painkillers after knee or hip replacement. About 150 adults with mild to moderate anxiety or depression symptoms will be enrolled. The program aims to improv…

This study tests a one-hour online program called UKADO for people waiting to start face-to-face therapy for anxiety or depression. About 312 adults will try different versions of the program to see which works best. The goal is to find a way to help people feel better while they…

This study tests a 4-week mindfulness program for mothers with postpartum anxiety. It aims to reduce anxiety, improve emotional control, and increase body awareness using questionnaires and brain scans. About 50 mothers in their first year after childbirth will participate.

This study compares two types of exposure training for people with spider phobia: in-person exposure with a real spider and video-based exposure via video chat. About 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting list. Researchers me…

This study tests a short, 30-minute online program designed to help caregivers (parents or guardians) of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers will measure changes in caregiver anxiety and how they s…

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study looks at whether qigong (a gentle mind-body exercise) or multicomponent exercise (a mix of activities) can reduce panic and anxiety symptoms in people with panic disorder. Researchers will measure changes in panic severity, anxiety, balance, walking, sleep, fatigue, pa…

This study tests whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided education program. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much pa…

This study tests if a brain-training technique called neurofeedback can help people with both coronary heart disease and anxiety. Participants will learn to control a part of their brain linked to stress, using a special audio-visual game. The goal is to see if this can lower hea…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study tests a new telehealth program called DINOSAUR for children ages 4 to 6 with autism who also have anxiety. The program teaches children and their parents strategies to handle worry and uncertainty. Researchers will see if the program reduces anxiety and improves daily …

This study is testing whether a treatment called TMS (transcranial magnetic stimulation) can reduce anxiety and depression in children and teens. About 120 young people aged 6 to 18 with a doctor's diagnosis will receive TMS, which uses magnetic pulses to stimulate the brain. The…

This study looks at whether adding a CBD medication (Epidiolex) to cognitive behavioral therapy helps adults with generalized anxiety disorder feel less anxious. About 90 people will take either CBD or a placebo alongside therapy sessions. The goal is to see if CBD makes the ther…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This study tests a culturally adapted cognitive behavioral therapy (CBT) for depression and anxiety in 50 adults living with HIV in Pakistan. Participants will either receive six therapy sessions from trained health workers or standard care. The goal is to see if this approach is…

This study looks at whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants will attend online group sessions and use a WeChat mini-program for guid…

This study aims to find genetic markers that may predict which children and youth (ages 6-24) with depression, anxiety, or OCD will experience behavioral activation—a side effect like agitation or restlessness—from SSRI antidepressants. Researchers will analyze DNA from 160 parti…

This study is looking at whether brain scans can help predict how well people with depression, insomnia, or social anxiety will respond to internet-based cognitive behavioral therapy (iCBT). Researchers will measure brain activity patterns in 150 patients and 75 healthy volunteer…

This study explores whether a non-invasive brain stimulation technique called rTMS can temporarily alter how people with anxiety disorders cope with fear. Researchers will measure brain activity and reactions to emotional situations in 80 adults who recently started anxiety treat…

This study looks at how exercise affects the brain in adults with anxiety disorders. Researchers will measure specific chemicals from brain cells found in blood samples to understand the biological changes caused by exercise. The goal is to learn more about the brain mechanisms t…

This study is testing whether an artificial intelligence (AI) tool can reliably measure the severity of depression and anxiety in adults. Researchers will compare the AI's assessments of video-recorded interviews with those made by human clinicians. The goal is to develop a more …

This study looks at how brain function and thinking skills are linked to anxiety in children and teens aged 8-17. Participants will have brain scans and complete thinking tasks before and after receiving either talk therapy (CBT) or the medication fluoxetine. The goal is to under…

This study aims to improve MRI scanning methods to better understand how mood and anxiety disorders affect the brain. Researchers will compare brain structure and activity in healthy volunteers and people with major depressive disorder while they perform tasks. The goal is to dev…

This study uses a non-invasive technology called transcranial focused ultrasound (tFUS) to temporarily change activity in a deep brain area involved in anxiety. Researchers want to see if this affects how people with anxiety disorders react to emotional situations. The study invo…

This study looks at how the brain handles threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences i…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assig…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…