Could a common antidepressant boost cancer immunotherapy?

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can improve tumor control and survival in 240 people with advanced liver or gallbladder cancer who also have depression or anxiety. Participants will receive either fluoxetine or a placebo alongside their immunotherapy. The goal is to see if treating mood symptoms can also enhance the anti-cancer immune response.