DEPRESSION DISORDERS

This study looks at whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help shrink tumors and extend survival in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 participants will be randomly assigned…

This study tests whether an online recovery education and support program, led by trained teen peers and support specialists, can help teens aged 15-18 who have been recently discharged from a psychiatric facility. The program includes one-on-one and small group meetings over 8 w…

This study tests a group mental health program for adults 55 and older who feel lonely, isolated, or have symptoms of anxiety or depression. The program is delivered by phone or video and teaches skills to handle difficult emotions. Researchers want to see if it improves well-bei…

This study tests whether a non-invasive brain stimulation called tACS can help teenagers aged 12-18 who hurt themselves (non-suicidal self-injury) gain better control over impulses. Sixty participants will receive either real or fake (sham) stimulation twice daily for a week. Res…

This study tests whether a new drug called CYB003 can safely reduce symptoms of major depression. About 330 adults with moderate to severe depression will receive either CYB003 or a placebo. The goal is to see if CYB003 improves mood and daily function better than a placebo.

This study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…

This study tests a new approach that combines meditation with real-time brain feedback to help people with moderate depression. 27 adults will try the intervention to see if it reduces depression symptoms and improves mindfulness. No medications are used, and the goal is to ease …

This study will look at 100 adults admitted to NHS mental health wards to learn about their physical and mental health. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like depression, mania, and anxiety. The goal is to bette…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. Researchers will use smartphone surveys and continuous glucose monitors to collect data from over 1,800 participants over two years. The go…

This study explores how depression and other mental health issues impact the severity of symptoms in people with graft-versus-host disease (GvHD), a complication after bone marrow transplant. Researchers will follow 200 adults and use questionnaires to measure mood, symptoms, and…

This study is testing whether an artificial intelligence (AI) tool can reliably measure the severity of depression and anxiety in adults. Researchers will compare the AI's assessments of video-recorded interviews with those made by human clinicians. The goal is to develop a more …

This study aims to find out how common depression is among healthcare workers in cardiothoracic surgery departments in Baghdad. About 200 doctors, nurses, and support staff will fill out a questionnaire called PHQ-9 to measure their depression symptoms. The study does not provide…

This study is testing a new online platform called Okaya that uses artificial intelligence to detect fatigue and depression in people with heart conditions. Researchers will compare the platform's results to standard questionnaires to see how accurate it is. The study involves 10…

This study looks at whether adding patients' own goals and concerns to their mental health care plan helps them stay more engaged. About 2,448 adults receiving collaborative care for anxiety or depression will take part. Researchers will compare standard care to an enhanced versi…

This study looks at whether a special eye-tracking device can spot changes in eye movements caused by long-term use of psychiatric medications like those for ADHD, depression, or anxiety. Researchers will test 50 adults who have been on these medications for over three months. Th…