DEPRESSION DISORDERS

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can improve tumor control and survival in 240 people with advanced liver or gallbladder cancer who also have depression or anxiety. Participants will receive either fluoxetine or a pl…

This study is testing whether an AI platform called Okaya can accurately detect fatigue and depression in people with heart conditions. Participants will complete standard questionnaires and an AI assessment that analyzes facial and vocal features. The goal is to see if the AI ma…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study tests an online recovery program for teens aged 15-18 who have been discharged from a psychiatric hospital after suicidal thoughts, attempts, depression, or anxiety. The program pairs them with trained peer support specialists and teen peers for one-on-one and group me…

This study tests a 10-session meditation practice combined with real-time brain feedback to help ease depression. Twenty-seven adults with moderate depression will participate. The goal is to see if this approach can improve mood and reduce symptoms.

This study compares heated yoga, sauna sessions, and a mindfulness app to see which best reduces symptoms of depression. Researchers at Massachusetts General Hospital are recruiting 120 adults aged 18-65 with moderate to severe depression. Participants will attend twice-weekly se…

This study tests a six-week group program delivered by phone or Zoom for adults 55 and older who feel lonely, isolated, or anxious. The program uses counseling techniques to help participants cope with difficult emotions and build connections. Researchers will compare the program…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can help teenagers who hurt themselves without wanting to die. Sixty teens aged 12-18 will receive either real or fake stimulation for 7 days. Researchers will measure changes in self-harm beh…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study looks at how common depression is among healthcare workers in cardiothoracic surgery departments in Baghdad, Iraq. About 200 doctors, nurses, and support staff will fill out a questionnaire called PHQ-9 to measure their depressive symptoms. The goal is to understand th…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study looks at how depression and other mental health issues impact symptom severity and quality of life in people with graft-versus-host disease (GvHD). Researchers will follow 200 adults with GvHD, using questionnaires to measure psychiatric status and symptoms. The goal i…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study is testing whether an AI tool can accurately measure depression and anxiety symptoms from video interviews. Researchers will compare the AI's ratings to those of human clinicians. The goal is to create a more consistent way to evaluate symptoms in clinical trials, whic…