Could a dissolving film under the tongue stop PTSD after a crash?

NCT ID NCT06943404

Recruiting now Disease control Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a drug called BXCL501, given as a film under the tongue, can reduce acute stress and prevent post-traumatic stress disorder (PTSD) in people who have been in a motor vehicle collision. One hundred adults who come to the emergency department within 72 hours of a crash will receive either the drug or a placebo for two weeks. Researchers will track their stress symptoms, thinking abilities, and any side effects over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine (BXCL501) sublingual film
What this could lead to: If it works, this could offer a way to reduce stress symptoms and prevent long-term PTSD after a traumatic event like a car crash.
What could go wrong: This is an early phase 2 trial with only 100 people, so results may not apply to everyone. The drug may cause side effects like low blood pressure or drowsiness.

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Conditions

The condition(s) this trial relates to.

acute stress disorder post-traumatic stress disorder Stress Disorders, Traumatic, Acute

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE STRESS DISORDER ACUTE STRESS REACTION POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

UVA University Hospital
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Florida College of Medicine - Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
Washington University in St. Louis
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States

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