Can daily CBD reshape your stress response? a study puts it to the test.

NCT ID NCT07069478

Recruiting now Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study investigates whether people who use cannabidiol (CBD) regularly react differently to acute stress compared to those who do not. Healthy adults aged 21–70 who either use CBD daily or not at all will undergo a series of stressful tasks — including public speaking, mental arithmetic, and an ice-water hand immersion — while researchers measure changes in mood, heart activity, and stress hormone levels. The goal is to understand the psychobiological mechanisms behind CBD's potential stress-relieving effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cannabidiol (CBD)
What this could lead to: If regular CBD use dampens the stress response, it could point toward a natural approach for managing everyday stress and anxiety.
What could go wrong: This is an observational comparison, not a controlled trial, so it cannot prove cause and effect. Differences between CBD users and non-users (like tobacco use) may influence results.

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Conditions

The condition(s) this trial relates to.

acute stress disorder red-green color blindness Stress Disorders, Traumatic, Acute

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE STRESS REACTION CANNABIDIOL CBD STRESS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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