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Can daily CBD reshape your stress response? a study puts it to the test.

NCT ID NCT07069478

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study investigates whether people who use cannabidiol (CBD) regularly react differently to acute stress compared to those who do not. Healthy adults aged 21–70 who either use CBD daily or not at all will undergo a series of stressful tasks — including public speaking, mental arithmetic, and an ice-water hand immersion — while researchers measure changes in mood, heart activity, and stress hormone levels. The goal is to understand the psychobiological mechanisms behind CBD's potential stress-relieving effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cannabidiol (CBD)
What this could lead to
If regular CBD use dampens the stress response, it could point toward a natural approach for managing everyday stress and anxiety.
What could go wrong
This is an observational comparison, not a controlled trial, so it cannot prove cause and effect. Differences between CBD users and non-users (like tobacco use) may influence results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 125 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults who are relatively healthy and aged 21-70 years. * Must keep a normal sleep schedule (sleep during nighttime, awake during daytime). * Must either (1) use CBD daily/regularly or (2) not use CBD regularly. Exclusion Criteria: * Participated in previous acute stress studies that included a similar stress induction. * Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100). * Self-reported current pregnancy. * Self-reported current use of illicit substances (other than cannabis). * Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.) * Students of the principal researcher

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Conditions

The condition(s) this trial relates to.

acute stress disorder red-green color blindness Stress Disorders, Traumatic, Acute

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute stress reaction Cannabidiol CBD Stress

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

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