ACUTE STRESS REACTION

This study tests whether a drug called BXCL501, given as a film under the tongue, can reduce acute stress and prevent post-traumatic stress disorder (PTSD) in people who have been in a motor vehicle collision. One hundred adults who come to the emergency department within 72 hour…

This study tests whether taking vitamin D daily for 8 weeks helps healthy adults keep their thinking, simple physical tasks, and mood steady during very stressful situations. 52 participants will take either vitamin D or a placebo, then perform tasks while wearing a belt that giv…

This study tests whether a sublingual tablet (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who come to the emergency room after a car crash. 180 participants will receive either the drug or a placebo for two weeks, starting in the ER. Research…

This study tests a short intervention called iCOVER, designed to help people quickly regain focus and calm after an acute stress reaction. The intervention takes just 60-120 seconds and can be given by peers or medical staff. Researchers will enroll 450 adults in an emergency dep…

This study looks at whether two FDA-approved drugs, propranolol and hydrocortisone, can prevent mental and physical performance drops after a stressful experience. Healthy adults aged 18-40 who are afraid of spiders will be briefly exposed to a tarantula, then given one of the dr…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just resting. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rate, str…