Can a 2-Minute chat reverse acute stress? new trial aims to find out
NCT ID NCT06482567
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a short intervention called iCOVER, designed to help people quickly regain focus and calm after an acute stress reaction. The intervention takes just 60-120 seconds and can be given by peers or medical staff. Researchers will enroll 450 adults in an emergency department who show signs of distress or dissociation, and compare iCOVER to usual care or simple reassurance. The goal is to see if iCOVER improves thinking and functioning right after the stressful event.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iCOVER (a brief behavioral intervention using steps: Identify, Connect, Offer commitment, Verify facts, Establish order, Request action)
What this could lead to
If it works, this could provide a quick, easy-to-use tool for peers or medical staff to help someone snap out of an acute stress reaction and think clearly again.
What could go wrong
This is an early efficacy trial with 450 participants, so results may not apply broadly. The intervention is very brief and may not work for everyone or in all stressful situations.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cooper University Health Care
RECRUITINGCamden, New Jersey, 08103, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Henry Ford Health System
RECRUITINGDetroit, Michigan, 48202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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McLean Hospital, Harvard Medical School
ACTIVE_NOT_RECRUITINGBelmont, Massachusetts, 02478, United States
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University of Massachusetts Chan Medical School
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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Washington University, St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact