University Of North Carolina, Chapel Hill

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this t…

This study tests whether a culturally-tailored program can help American Indian women improve their heart health. About 70 women will either join 8 weekly classes or a control group. Researchers will check blood pressure, stress, and other health markers over 3 months to see if t…

This study tests whether adding a chatbot to a smartphone weight loss program helps young adults lose weight and stay engaged. Twenty overweight or obese adults will use either a standard app or one with a chatbot for 12 weeks. Researchers will measure how often participants use …

This study tests a program called CommunityRx-Kidney Health for people with early-stage chronic kidney disease living in rural North Carolina. The program connects patients with medical care, community resources, and self-care tools to improve their health. Researchers will see i…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals plus c…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous treatment (anti-TNF drugs) stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and pr…

This study tests a new device called LOBO to block abnormal blood vessels in the lungs (PAVMs) that can cause serious problems. About 30 people will get the procedure and be followed for 3 years with scans to see how well the device works. The goal is to see if the device safely …

This early-stage study tests whether two experimental antibodies (MGD014 and MGD020) are safe in people with HIV who are on standard antiretroviral therapy. Some participants also receive a drug called Vorinostat to help expose hidden HIV, or temporarily stop their HIV meds. The …

This study aims to find the best telehealth weight loss approach for older adults (ages 65-85) who have obesity and at least two chronic conditions. Researchers will compare different treatment combinations to see which helps participants lose the most weight over 52 weeks. The g…

This study looks at whether giving medication once a day through a chest tube is as effective as twice a day for treating serious infections around the lungs. About 270 adults hospitalized with pleural infections will be randomly assigned to receive either once-daily or twice-dai…

This study tests whether mirikizumab can reduce symptoms of chronic pouch inflammation in 25 adults. Participants receive the drug every 4 weeks for a year and track their symptoms. The goal is to see if it helps control the condition without needing ongoing antibiotics.

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food-as-medicine program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. Sixty participants will be split into two groups: one gets the standard…

This study tests two different surgical techniques for people who need repeat eyelid surgery for trichiasis, a condition where eyelashes grow inward and scratch the eye. Researchers will enroll 1,000 participants in Tanzania and compare a newer method (B-RAP) with the standard on…

This study tests a drug called finerenone in people who have had a kidney transplant. The goal is to see if it can help protect the new kidney and reduce complications. About 100 adults who received a transplant 1 to 10 years ago will take either finerenone or a placebo. The stud…

This study looks at whether giving people healthy prepared meals and education helps them eat better compared to just getting physical activity coaching. About 120 adults in Anson County who have or are at risk for chronic diseases like obesity, diabetes, or heart disease will ta…

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women with HIV and depression in Malawi. Researchers will enroll 400 women to see if the program reduces depression symptoms and helps them stay in H…

This study tests whether adding data accountability tools and community-based doula support to standard care can reduce racial disparities in pregnancy. About 60,000 patients at 39 prenatal clinics in North Carolina will take part. The goal is to lower the number of low-birthweig…

This study is testing whether a special type of PET/MRI scan can accurately diagnose endometriosis. Researchers will enroll 24 women who are suspected of having the condition. The goal is to see if this imaging method can detect endometriosis without needing surgery, potentially …

This study looks at whether two HIV prevention methods—a long-acting shot and daily pills—are safe for pregnant women and their infants in Malawi. About 621 pregnant women already using or starting HIV prevention will choose either the shot or pills and be followed through pregna…

This study is testing a new approach called PAC-Man to help prevent HIV transmission from mothers to their babies in Malawi. About 2,426 mothers and infants will take part to see if this model improves timely HIV testing and viral load checks compared to standard care. The goal i…

This study tests a program called PriCARE/CARIÑO that helps parents and children ages 1.5 to 6 years build stronger relationships and reduce stress. About 1,932 families will take part to see if the program lowers the risk of child maltreatment and harsh parenting. The goal is to…

This study tests whether combining job support with HIV prevention education helps young adults (ages 18-24) in Baltimore improve their economic stability and reduce risky sexual behaviors. About 500 participants will be randomly assigned to receive either job alerts alone or job…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults in Lilongwe, Malawi will either get the program or usual care. The goal is to see if it reduces heavy drinking and increases HIV preventio…

This study is testing a 90-day support program called 'Caring Connections' designed to prevent suicide in high-risk teenagers. The program connects teens with mental health services, helps create safety plans, and builds a network of community support, often through faith-based o…

This study tests a mobile health app called Bolster designed to help caregivers of young adults with early psychosis. Researchers want to see if the app can reduce caregiver distress and improve family communication. About 30 caregivers in North Carolina will use the app and repo…

This study tests a new way to help teenagers in rural India with mental health issues like depression and anxiety. Instead of specialists, trained teachers will deliver the care. The goal is to see if this approach is practical and can improve teens' emotional well-being.

This study tests a transitional care program for people with Alzheimer's or dementia who are leaving a skilled nursing facility to go home, to assisted living, or to long-term care. The program also supports their caregivers. The goal is to see if the program can reduce caregiver…

This study tests whether a telehealth program called REAL-Fam can help families in rural areas manage their child's type 1 diabetes. About 16 families will either receive 12 video sessions with an occupational therapist or just 3 check-in meetings. The goal is to see if the progr…

This early study is testing whether a gentle, personalized electrical brain stimulation (tACS) is safe and tolerable for pregnant women with depression. Ten participants (5 with depression and 5 healthy) will receive the stimulation and be monitored for side effects and birth out…

This small pilot study tests whether a 5-week outdoor mindful walking and running program, guided by the Headspace app, is practical and helpful for people with patellofemoral pain (pain around the kneecap). Researchers will enroll 20 adults to see if the program reduces knee pai…

This study tests whether training with a metronome—using slow beats on a treadmill and fast beats while walking on the ground—can improve how people with Parkinson's disease walk. Over 12 one-hour sessions, 45 participants will practice stepping to different speeds and have their…

This study tests whether a numbing injection around the cervix (paracervical block) given during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers after surgery. About 56 participants will receive either the numbing medicine or a p…

This study tests whether a program combining gradual exposure to feared movements and mindfulness meditation can help people who had ACL knee surgery feel less afraid of re-injury. Researchers will compare the program to a waitlist group in 50 participants aged 14-35 who are 6 mo…

This study tests a new approach for people with major depression that hasn't improved with standard treatments. Thirty participants will receive a single session that combines psychotherapy, a type of brain stimulation called TMS, and either real or fake electrical brain stimulat…

This study tests a new fast-dissolving film (BXCL501) to see if it can reduce severe stress and prevent PTSD in people who have just been in a car accident. About 100 adults will receive the film or a placebo in the emergency room and take it at home for two weeks. Researchers wi…

This study looks at whether the Alliance180 Program can improve anxiety, depression, and overall well-being in adults who are or were US veterans, first responders, or frontline healthcare workers. About 50 participants will complete surveys before the program and again up to 6 m…

This study tests a 90-day program called Caring Connections that helps high-risk youth ages 13-19 who have suicidal thoughts or behaviors. The program provides support, safety planning, and connections to services. Researchers will compare this program to usual care to see if it …

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve may get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a 3-D brain imaging technique called tractography can make focused ultrasound treatment for essential tremor more precise and safer. About 24 adults with moderate to severe hand shaking that hasn't responded to medication will receive the procedure. Resea…

This study tests if a special nerve block (phrenic-sparing) can reduce early breathing problems after shoulder surgery in adults with obesity, compared to the standard block. About 68 participants will be randomly assigned to receive one of the two blocks. Researchers will check …

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which one works better for autistic adults with depression or anxiety. About 300 participants from North Carolina and Virginia will receive therapy sessions …

This study tests whether a telehealth behavioral therapy can reduce PTSD and depression symptoms in adults who recently experienced a motor vehicle collision. Twenty high-risk participants will receive either the therapy or a control session. The goal is to see if this approach i…

This study tests two numbing medicines for wrist fracture surgery: standard bupivacaine and a longer-acting version called liposomal bupivacaine (Exparel). About 100 adults having wrist surgery will receive one of the two drugs as a nerve block. The goal is to see which provides …

This study tests a sublingual (under-the-tongue) tablet called TNX-102 SL to see if it can reduce severe stress reactions and prevent post-traumatic stress disorder (PTSD) in people who have just been in a car accident. 180 adults who come to the emergency room within 72 hours of…

This study tests a 60-120 second technique called iCOVER to help people who are extremely stressed or in shock (acute stress reaction). Researchers will compare iCOVER to usual care or simple reassurance in 450 adults in the emergency department. The goal is to see if iCOVER can …

This pilot study tests whether acetaminophen (Tylenol) or ibuprofen (Advil) works better for period cramps in women with Crohn's disease. About 24 women with stable Crohn's will take each medication for two menstrual cycles and report their pain. The main goal is to see if a larg…

This study tests a rehabilitation program for soldiers who have had a mild traumatic brain injury (concussion). The program adds extra activities to standard recovery guidelines to help soldiers return to duty faster and improve their thinking and daily function. About 130 active…

This study looks at whether virtual reality mindfulness meditation can help women aged 14-25 who had ACL knee surgery feel less afraid of re-injury and move better during jumping. Participants will use VR meditation or a sham version for 8 weeks. The goal is to see if this approa…

This study is testing a virtual reality (VR) program for teens ages 13-18 who are in the hospital for suicidal thoughts or behaviors. The VR program lets them practice school and social situations in a safe, guided environment. The goal is to see if the program is easy to use and…

This study looks at whether the hormone estradiol can help perimenopausal women who started having depression, psychosis, or loss of interest in rewards during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use brain s…

This study tests a new cognitive behavioral therapy (CBT) program for parents and caregivers of young people who have experienced psychosis. The goal is to see if the program is practical and helpful for reducing caregiver stress, loneliness, and symptoms of anxiety and depressio…

This study looks at how different colors of light can change pain perception by measuring brain activity. Researchers will compare people with chronic muscle or fibromyalgia pain to healthy volunteers. Participants undergo brain scans while viewing colored lights and receiving mi…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen around birth. All babies are receiving standard cooling therapy. The goal is to find the right dose and check for safety. 16 newborns will…

This pilot study is testing whether a 12-week personalized nutrition supplement (beta-hydroxy-methylbutyrate) is practical and acceptable for adults aged 65 to 85. Researchers will measure how many people join and stick with the program, and also look at changes in strength, walk…

This study tests whether banning menthol cigarettes, along with a quit-smoking campaign, changes what people buy. About 1,185 adults who smoke menthol cigarettes will be followed to see if they stop buying tobacco or switch to other products. The goal is to understand how such a …

This study explores a new type of MRI that uses a harmless gas to create images of lung function in children aged 6-17 with mild cystic fibrosis and healthy children. The goal is to see if this technique is practical and acceptable for kids, and to compare it with standard lung t…

This study looks at how natural hormone changes during the menstrual cycle affect mood and the ability to feel pleasure in women whose depression gets worse before their period. Researchers will give participants hormone patches and pills to stabilize hormone drops, then measure …

This study looks at whether a physical therapy program in the NICU can lower stress for parents and help them care for their preterm babies. About 150 infants born before 29 weeks and their mothers will take part. Researchers will track therapy visits, parent involvement, and bab…

This study looks at how a common heart medication (beta-blocker) changes the body's inflammatory response to stress. Researchers will measure immune markers and brain activity in 120 healthy adults aged 18-30. The goal is to find new ways to reduce heart disease risk by understan…

This study looks at how breathing in woodsmoke changes the way your nose and immune system react to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to mimic infection. Researchers will measure immune markers and…

This study tests whether a 10-session parenting program called Attachment and Biobehavioral Catch-up (ABC) can lower stress-related biomarkers in children aged 2 to 3 who have experienced early life adversity. About 150 caregiver-child pairs will be randomly assigned to receive t…

This study looks at how the brain talks to muscles in people who have had a stroke. Researchers will use a cap and stickers to measure brain and muscle activity while participants squeeze a hand grip. They will also test two types of gentle brain stimulation to see if it helps im…

This study looks at how stress and personality traits influence decision-making in people with borderline personality disorder (BPD). Researchers will have 106 participants (ages 18-45) complete online tasks, surveys, and a stress test while monitoring heart rate, sweat, and bloo…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This study looks at whether adding warning labels about added sugar on sugary drinks can influence what people choose to buy. About 543 adults who regularly buy sugary drinks will shop in a mock store and answer surveys over four weekly visits. The goal is to see if the labels re…

This study looks at whether breastfeeding mothers who eat whole eggs pass more brain-boosting nutrients (like choline and DHA) to their babies through breast milk. 84 mother-infant pairs will take part, with some moms eating whole eggs and others eating egg whites. Researchers wi…

This study aims to understand what sensations can be created by stimulating the spinal cord in people who already have a spinal cord stimulator for chronic pain. Researchers will test how changing the stimulation strength affects what participants feel. The goal is to learn how t…

This study looks at whether the brain activity of a therapist and a client can become synchronized during a therapy session for mild to moderate depression. Researchers will measure brain waves using EEG while participants receive either behavioral activation therapy or psychoedu…

This study looks at how interrupting long periods of sitting can affect your heart and blood vessels. Researchers will test different strategies in 56 adults aged 30-60 who sit a lot and exercise little. The goal is to find practical ways to reduce sitting that could lower the ri…

This study looks at whether warning labels on sugary drinks affect people's biases about weight. About 543 adults will shop in a pretend store and answer surveys over four weekly visits. The goal is to see if these labels change how people judge others with obesity. No treatment …

This study looks at why depression and heart disease often occur together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55 to see if changes in these pathways explain the link. The goal is to find new ways t…

This study tests whether new front-of-package health warnings on alcohol containers can reduce how much people drink. About 720 adults who drink at least once a week will bring their own alcohol to study visits and receive either new warning labels or standard control labels. Res…

This study enrolls 324 parent-child pairs to find better ways to support parents during hypospadias care. Parents and children are placed into different groups and followed for at least 6 months. Researchers will measure how well the support works by looking at parent feedback an…

This study compares two programs for child care staff: one focused on building resilience and stress management, the other on physical activity. About 640 staff from 80 centers will take part for 15 months. The goal is to see which program better improves well-being over time.

This study tests a program called PACE that helps adults with intellectual disability become more physically active. About 120 adults, along with their caregivers and coaches, will take part. The program focuses on increasing daily steps and moderate-to-vigorous activity, and the…

This study looks at whether taking a daily supplement called SPM Active® for 12 weeks can increase certain omega-3-related substances in the blood and improve well-being in adults with obesity. About 33 people aged 45-60 with a BMI between 30 and 40 will take two soft-gel capsule…

This study looks at whether breastfeeding mothers who eat one avocado daily for 12 weeks can increase important nutrients in their milk, like choline and lutein, which may help their baby's brain development. About 88 healthy mothers and their 3-month-old infants will take part. …

This study looks at whether wearing clear aligners (like Invisalign) causes tiny plastic particles to get into your saliva and urine. Researchers will collect samples from 150 orthodontic patients before and during treatment. The goal is to understand if these aligners release mi…

This study looks at whether easy-to-do tests for muscle strength, breathing, and frailty can help predict complications after major abdominal surgery in people aged 65 and older. About 100 participants will complete these tests during a routine pre-surgery visit, and researchers …

This study tests whether virtual family navigation helps families in rural North Carolina start autism intervention sooner for toddlers under 4. Sixty families will either get 4 coaching sessions with a navigator or standard educational materials. The goal is to see if this suppo…

This study looks at why some people with Alpha-Gal syndrome get stomach pain, diarrhea, or vomiting after eating pork. Researchers will give 30 adults pork with and without a certain sugar (alpha-gal) in a blinded test to see if it triggers an allergic reaction. They will also me…

This study aims to see if newly developed wearable sensors are comfortable and safe for healthy adults aged 18 to 99. Researchers will compare the sensors' readings of heart rate, breathing, and blood flow to those from approved medical devices. The goal is to gather information …

This study looks at how well lungs work in adults with cystic fibrosis using a special MRI that uses an inhaled gas. Researchers will track 30 people over a year to see how their lungs change, especially during a flare-up. The goal is to better understand lung problems, not to tr…