University Of North Carolina, Chapel Hill

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This study tests whether an 8-week culturally-adapted program can improve cardiovascular health in American Indian women aged 18-55 who have heart disease risk factors. Participants are randomly assigned to either the program or a control group. Researchers will measure changes i…

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This early-stage study tests whether a single dose of an experimental drug called IAP086 is safe in 30 adults with HIV whose virus is already well-controlled by standard antiretroviral therapy. Participants receive one intravenous infusion and are monitored closely for 28 days. T…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This study tests a group training program called PriCARE/CARIÑO for parents of children aged 18 months to 6 years. The program teaches skills like praising good behavior and ignoring minor misbehavior to improve parent-child relationships and reduce stress. Researchers will follo…

This study tests a program called CommunityRx-Kidney Health for people with early-stage chronic kidney disease living in rural North Carolina. The program connects patients with medical care, social services, and self-care resources to help manage their condition. Researchers wil…

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This large study in North Carolina tests whether giving clinics data tools and racial equity training, plus offering doula support to high-risk Black patients, can reduce low birthweight and discrimination in prenatal care. About 60,000 patients from 39 clinics will take part. Th…

This study tests whether a drug called BXCL501, given as a film under the tongue, can reduce acute stress and prevent post-traumatic stress disorder (PTSD) in people who have been in a motor vehicle collision. One hundred adults who come to the emergency department within 72 hour…

This study tests whether finerenone, a drug already used for kidney disease, can help protect transplanted kidneys. About 100 adults who received a kidney transplant 1 to 10 years ago will take either finerenone or a placebo daily for 12 months. Researchers will check how well th…

This trial tests two surgical methods for repeat eyelid surgery in people with trichiasis, a condition where eyelashes rub against the eye. About 1,000 participants in Tanzania will receive either the B-RAP or BLTR procedure. The goal is to see which technique better prevents eye…

This study tests a 90-day program called Caring Connections for youth aged 13-19 who are at high risk for suicide. The program helps them stay engaged with mental health services, create safety plans, and build a support network. Researchers will compare 40 youth who receive the …

This study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…

This study tests a device called LOBO™ to block abnormal blood vessels in the lungs (PAVMs). About 30 people will get the procedure and be followed for 3 years with CT scans to see if the vessels stay closed. The goal is to see how well the device works compared to standard treat…

This study tests whether mirikizumab (Omvoh) can reduce symptoms of chronic pouchitis, a condition where the internal pouch created after colon surgery becomes inflamed. Twenty-five adults will receive the drug every four weeks for a year. Researchers will track symptom changes u…

This study tests whether using 3-D tractography—a detailed brain imaging method—can make focused ultrasound ablation safer and more effective for people with essential tremor. Twenty-four adults with moderate to severe tremor that hasn't responded to medication will receive the p…

This study tests whether two experimental antibodies (MGD014 and MGD020) are safe in people with HIV who are on standard antiretroviral therapy. Some participants also receive a drug called Vorinostat to help expose hidden HIV, or temporarily stop their regular HIV meds. The goal…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food-as-medicine program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. Sixty participants will be split into two groups: one gets the standard…

This study tests whether providing healthy frozen meals, produce boxes, and nutrition counseling helps adults in Anson County eat better compared to those who only get physical activity coaching. About 120 participants with or at risk for chronic diseases like obesity, diabetes, …

This study compares ultrasound to standard X-ray (fluoroscopy) for checking whether a feeding tube is correctly placed in children. Ten children who recently had a feeding tube replaced will get an ultrasound before their routine X-ray. Researchers want to see if ultrasound is ju…

This study looks at whether a simple questionnaire given during a dental checkup can identify children at risk for sleep-disordered breathing (like sleep apnea). Sixty children aged 8-13 will fill out the questionnaire and then wear a home sleep monitor for one night to measure t…

This study tests a special PET/MRI scan to see if it can accurately diagnose endometriosis. Researchers will scan 24 women with suspected endometriosis and compare the results to surgical findings. If successful, this scan could help diagnose the condition more easily and reduce …

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This study tests a program that combines job-finding support with HIV prevention education for 500 young adults aged 18-24 in Baltimore who face economic hardship. Participants are randomly assigned to receive either job alerts alone or job alerts plus extra HIV prevention texts,…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults from an STI clinic in Lilongwe, Malawi, will either get the program or usual care. The goal is to see if the program reduces heavy drinkin…

This study is testing a new approach called PAC-Man to help prevent HIV from passing from mothers to their babies. About 2,426 mothers and infants in Malawi will take part. The goal is to see if this model helps more babies get tested for HIV early and ensures mothers receive pro…

This study is testing a 90-day support program called 'Caring Connections' designed to prevent suicide in high-risk teenagers. The program connects teens with mental health services, helps create safety plans, and builds a network of community support, often through faith-based o…

This study tests whether a non-invasive brain stimulation technique called TMS can help with apathy—a common lack of motivation—in people with Parkinson's disease. Sixty participants will receive TMS to two different brain areas on separate visits and perform a task where they ch…

This study tests whether walking with a metronome at different speeds can improve how people with Parkinson disease walk. 45 participants will do 12 training sessions on a treadmill and overground, using slow and fast beats to encourage larger and faster steps. Researchers will m…

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 …

This study looks at whether having a therapy dog present during a dental visit can lower stress in children. About 225 kids aged 4 to 8 will be randomly assigned to have a dental exam with or without a dog. Researchers will measure stress by tracking heart rate and testing saliva…

This study tests a new Cognitive Behavioral Therapy (CBT) program designed to help parents and caregivers of young people who have experienced psychosis. The program includes four core sessions plus extra modules based on each caregiver's needs. Researchers will check if the prog…

This study tests a mobile health app called Bolster designed to help caregivers of young adults (ages 15-30) with early psychosis. The goal is to reduce caregiver stress and improve family communication. About 30 caregivers in North Carolina will use the app and report on their w…

This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly …

This pilot study tests whether a short, video-based sleep therapy can help prevent PTSD and depression in people who recently had a car accident. Twenty adults at high risk for PTSD will receive either the sleep therapy or a control session over three weeks. The goal is to see if…

This study looks at whether using virtual reality for mindfulness meditation can help women aged 14–25 who had ACL knee surgery feel less afraid of re-injury and move better. Participants will use VR meditation or a sham version, and researchers will measure fear levels, jumping …

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study tests whether a sublingual tablet (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who come to the emergency room after a car crash. 180 participants will receive either the drug or a placebo for two weeks, starting in the ER. Research…

This study looks at whether a daily protein supplement called Triple Support Protein can help healthy women aged 30-60 improve their blood sugar levels and overall well-being. Forty women will take the supplement or a placebo for 4 weeks and have their blood sugar, insulin, and b…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This study tests a program called Connect-Home ADRD that helps nursing home staff and caregivers support dementia patients when they move to home, assisted living, or long-term care. About 360 patients and their caregivers will take part. The goal is to see if the program reduces…

This study tests a structured rehabilitation program for active-duty soldiers who have had a mild traumatic brain injury (concussion). The program includes low-intensity aerobic exercise, balance, and cognitive activities tailored to each soldier's symptoms and job demands. Resea…

This study tests whether a resilience training program can improve mental health and well-being in child care staff. About 640 workers from 80 centers will either take part in a resilience program or a physical activity program for 3 months, then be followed for a year. The goal …

This study tests whether a 3-day program called Alliance180, which includes working with horses, can improve anxiety, depression, and overall well-being in adults who are or were US veterans, first responders, or frontline healthcare workers. Fifty participants will fill out ques…

This study is testing whether a daily omega-3 supplement called SPM Active® can increase certain fatty acids in the blood and improve feelings of burnout, life satisfaction, and sleep quality. Researchers will enroll 33 adults aged 45-60 with obesity (BMI 30-40). Participants wil…

This study tests different telehealth weight loss programs for adults aged 65-85 who have obesity and at least two chronic health conditions. Participants will receive a personalized diet and exercise plan designed to be safe for their specific health needs. The goal is to find t…

This study compares two types of nerve blocks for shoulder surgery in adults with obesity. The standard block can sometimes weaken breathing muscles, while the experimental 'phrenic-sparing' block aims to avoid that. Researchers will measure breathing problems and pain control in…

This study tests a program called REAL-Fam, designed to help families in rural areas manage a child's type 1 diabetes. About 16 families will either receive 12 telehealth sessions focused on diabetes routines and family participation, or just 3 basic check-in meetings. The goal i…

This study tests a short intervention called iCOVER, designed to help people quickly regain focus and calm after an acute stress reaction. The intervention takes just 60-120 seconds and can be given by peers or medical staff. Researchers will enroll 450 adults in an emergency dep…

This study tests whether combining graded exposure therapy with mindfulness meditation (via the Headspace app) can reduce injury-related fear and improve reaction time in people who had ACL reconstruction. Fifty participants aged 14-35, who are 6 months to 10 years post-surgery a…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve can get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a numbing medicine injected around the cervix during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers afterward. About 56 participants will receive either the numbing medicine or a placebo (saltwater) inje…

This study tests if a longer-lasting painkiller (liposomal bupivacaine) works better than the standard one for wrist fracture surgery. About 100 adults will receive a nerve block before surgery, and their pain and recovery will be tracked for 48 hours. The goal is to find a way t…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which works better for autistic adults with depression and anxiety. About 300 participants from North Carolina and Virginia will receive therapy via teleheal…

This study looks at how medicines are processed in the bodies of children under 8 who are receiving drugs not specifically approved for their age or condition. Researchers measure drug levels in blood, urine, and spinal fluid to understand absorption, distribution, and eliminatio…

This study enrolls 324 parent-child pairs to see if a specially designed educational website helps parents feel more supported during hypospadias care. Parents are randomly assigned to either the study website or a basic information site. The goal is to learn how to improve commu…

This study aims to find the genes that keep airways healthy and understand how genetic mutations cause primary ciliary dyskinesia (PCD), a rare disease that leads to serious lung problems. Researchers will study people with suspected PCD and healthy family members. The goal is to…

This study looks at how stress and personality traits influence decision-making in people with borderline personality disorder (BPD) compared to healthy adults. About 106 participants aged 18-45 will complete online tasks, a stress test, surveys, and have their heart rate, sweat …

This study looks at how jaw surgery affects speech in people with bite problems like open bite or underbite. Researchers will record patients' speech and tongue movements before and after surgery to see what changes. The goal is to understand why many jaw surgery patients have sp…

This study helps U.S. healthcare centers figure out if patients are getting NTM lung infections from the hospital environment. Researchers will compare germs from patients' lungs with germs from water and dust in the hospital and homes. The goal is to create a standard method to …

This study investigates how colored light affects pain by scanning the brains of 60 people—half with chronic musculoskeletal pain (like fibromyalgia) and half healthy. Participants will view different light patterns while their brain activity is measured, and some will also recei…

This study looks at how breathing in woodsmoke changes the way your nose's immune system responds to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to mimic infection. Researchers will measure immune markers an…

This study looks at what happens when menthol cigarettes and flavored little cigars are removed from store shelves, combined with quit-smoking ads sent by text. About 1,185 adults who smoke menthol cigarettes will shop in a mock store and answer surveys. The goal is to see if the…

This study looks at how the brain talks to muscles in people who have had a stroke. Researchers will use gentle, non-invasive brain stimulation and measure brain and muscle activity while participants squeeze a device with their weak hand. The goal is to see if this stimulation c…

This study looks at whether breastfeeding mothers who eat one avocado daily for 12 weeks can increase key brain-supporting nutrients in their milk. Researchers will measure nutrients like choline and lutein in the milk and test the babies' memory and thinking skills at 4.5 and 6 …

This study looks at whether breastfeeding mothers who eat whole eggs pass along more brain-boosting nutrients (like choline and DHA) to their babies compared to mothers who eat only egg whites. About 84 mothers and their 3-month-old infants will take part over three months. Resea…

This study aims to see if newly developed wearable sensors are comfortable and safe for healthy adults aged 18 to 99. Researchers will also check if these sensors accurately measure vital signs like heart rate and breathing compared to approved medical devices. The goal is to gat…

This study looks at whether warning labels on sugary drinks affect people's biases about weight. Over 500 adults will shop in a mock store and answer surveys about their beliefs regarding people with obesity. The goal is to understand potential unintended effects of nutrition lab…

This study compares two online training programs for assisted living staff who care for people with dementia. One program is a self-paced web course called essentiALZ; the other adds a virtual mentoring group called Project ECHO. Researchers will track changes in staff knowledge,…

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if …

This study looks at how interrupting long periods of sitting with short walking or standing breaks affects heart and blood vessel health. Researchers will compare different break schedules in 56 sedentary adults aged 30-60. The goal is to find simple, practical strategies that co…

This study tests whether a 12-week personalized nutrition supplement (beta-hydroxy-methylbutyrate) can improve physical function in adults aged 65-85 with frailty and multiple chronic conditions. The main goal is to see if the study procedures are feasible and acceptable to parti…

This study tests whether putting warning labels on sugary drinks helps people choose healthier options. Over 500 adults will shop in a mock store and see either a warning label or a plain label on drinks. Researchers will track how much sugar people buy and drink over four weekly…

This study tests a new MRI method that uses an inhaled gas to create detailed images of lung ventilation in people with cystic fibrosis. Researchers will track 30 adults with mild lung disease over a year, comparing the MRI results to standard breathing tests. The goal is to see …

This study looks at how different ways of providing physical therapy in the NICU affect preterm infants born before 29 weeks. Researchers will compare standard care with more immersive therapy models to see which helps improve infants' motor skills and reduces parent stress. Abou…

This study explores a new type of MRI that uses an inhaled gas to create images of lung ventilation in children ages 6-17. Researchers will compare results between children with mild cystic fibrosis and healthy children to see if the technique is feasible and sensitive to early l…

This study tests whether a 10-session parenting program called Attachment and Biobehavioral Catch-up (ABC) can reduce stress-related biomarkers in children aged 2 to 3.5 years who have experienced early adversity. About 150 caregiver-child pairs will be randomly assigned to recei…

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This study looks at whether easy, quick tests for frailty and muscle strength can help predict complications after major abdominal surgery in adults aged 65 and older. About 100 participants will do brief assessments during a routine pre-surgery visit, and researchers will check …

This study looks at how sex hormones during puberty might affect mood differently in boys and girls. Researchers are testing a 4-week smartphone training program called Healthy Minds Program in 60 adolescents aged 11-14. The goal is to understand the brain and hormone changes tha…

This study looks at why depression and heart disease often occur together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55. The goal is to find clues that could lead to better ways to reduce heart disease ri…

This study explores whether teachers can be trained to deliver mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach is practical and effective for improving teen mental health.

This study looks at whether the brain activity of a therapist and a client can become synchronized during a therapy session for mild to moderate depression. Researchers will measure brain waves using EEG while students receive either behavioral activation therapy or education abo…

This study looks at how natural ups and downs of estrogen and progesterone during the menstrual cycle affect mood and the ability to feel pleasure in women whose depression gets worse before their period. Researchers will give 75 women hormone patches and pills to temporarily sta…

This study tests whether a single dose of the beta-blocker propranolol can reduce inflammation caused by psychological stress. Researchers will measure immune markers and brain activity in 120 healthy young adults before and after a stressful task. The goal is to understand the l…

This study tests whether virtual coaching, called Family Navigation, helps families in rural North Carolina start autism therapy faster for toddlers under 4. Some families get 4 telehealth sessions with a trained navigator, while others receive standard educational materials. The…

This observational study tracks 150 orthodontic patients to measure microplastic particles in their saliva and urine before and during clear aligner treatment. Researchers want to see if wearing clear aligners increases microplastic exposure over time. The study does not test any…