University Of North Carolina, Chapel Hill

This study tests whether adding an AI chatbot to a 12-week smartphone weight loss program helps young adults with overweight or obesity lose more weight and stay engaged. Twenty participants will either get the standard program or the program plus a chatbot for extra support. Res…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tiss…

This study tests a mobile health tool used by community health workers to follow up with women at home after a C-section. The tool asks about symptoms and takes a photo of the wound to check for infection. Researchers want to see if this approach helps catch complications earlier…

This study looks at how well dupilumab, an already approved drug, works for people with severe eosinophilic esophagitis (EoE) that has caused narrowing of the esophagus. About 23 participants aged 16 and older will receive weekly injections of dupilumab for one year. The goal is …

This study tests whether baricitinib, a drug used for arthritis, can help people with moderate to severe oral lichen planus—a painful mouth condition. Ten adults who haven't improved with other treatments will take the drug for six months. Researchers will measure changes in mout…

This study tests whether anifrolumab, an antibody drug, can reduce skin abscesses and nodules in people with hidradenitis suppurativa (HS). Fifteen adults with moderate-to-severe HS will receive the drug intravenously over 24 weeks. The main goal is to see if at least half of par…

This study tests a program called Tealeaf, where teachers in rural Indian schools provide mental health support to children with behavioral issues. Over 20,000 students from 90 schools will take part. The goal is to see if this teacher-led approach can improve children's behavior…

This study looks at whether a program called Heart Matters can help Black adults in rural eastern North Carolina lower their blood pressure. About 173 people with at least one heart disease risk factor (like high blood pressure or obesity) will take part. The program is led by co…

This early-stage study tests whether a person's own lung stem cells, grown from a small biopsy and given through an IV, are safe for treating idiopathic pulmonary fibrosis (IPF). Twenty-four adults with IPF will receive either a low or high dose of stem cells or standard care. Th…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This study tests a community-based program called Thriving Hearts across ten North Carolina counties. Pregnant individuals at risk for hypertensive disorders receive a care kit with a home blood pressure monitor and stress management tools, plus extra support from healthcare prov…

This study tests a mobile health program called Fit for Duty-mobile to help 350 active-duty Air Force members aged 18-39 prevent weight gain over 2 years. Participants use a smartphone app, get coaching calls, and wear a Fitbit. The goal is to see if this approach can stop unheal…

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

This study tests whether a brief alcohol intervention (a few counseling sessions) helps people who are starting or restarting PrEP (HIV prevention pills) to drink less and stick with their PrEP routine. About 562 participants in Hanoi will be randomly assigned to receive the inte…

This study tests a 9-week virtual group program that teaches mindfulness, yoga, nutrition, and self-massage to help people with chronic pain. It is being offered at Federally-Qualified Health Centers, which serve low-income patients. The goal is to see if the program can be succe…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults will receive one or two doses and be followed for a year to see if their symptoms…

This study tests whether special lights placed over doorways can help reduce nighttime falls in assisted living residents with Alzheimer's or related dementias. The lights are low-intensity and outline the bathroom or entry door, providing visual cues to improve balance. Research…

This study tests whether a 2-minute perineal massage before a pessary exam can reduce pain and discomfort. 68 women with prolapse or incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, non-drug way to improve comfort during r…

This study aimed to compare two pain medicines given into the spinal fluid during C-section for patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery. However, the trial was withdrawn before any pa…

This study looks at whether taking omega-3 supplements (fish oil) for 12 weeks can reduce migraine pain and improve quality of life in children aged 10 to 17. Half of the 58 participants will receive omega-3 oil, and the other half will receive a placebo (coconut oil). Researcher…

This study explores whether shining specific colors of light into the eyes can help people with chronic low back pain or fibromyalgia feel less pain. Sixty adults will use a portable light device for 2 hours daily over 5 days. The goal is to see if this approach is practical and …

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. One program is a safety planning intervention (SPI-A), and the other adds follow-up contacts (SPI-A+). Researchers will track changes in suicidal thoughts and behaviors over a…

This study follows 40 adults aged 55+ with osteoarthritis who are getting low-dose radiation as part of their usual care. Researchers will track pain, function, and quality of life for up to a year to see if the treatment helps. The goal is to understand how well this approach wo…

This study collects blood and tissue samples from 1,000 adults with Barrett's esophagus or esophageal cancer during their routine endoscopy. The goal is to build a biorepository that links clinical data with specimens, enabling future research into these conditions. Participants …

This study looks at whether regular text message check-ins and the ability to text your IBD care team can improve disease management and quality of life. About 900 people with Crohn's disease or ulcerative colitis will take part. Some will get extra symptom surveys and texting ac…

This study compares two programs for parents of teens and young adults (ages 11-27) with intellectual or developmental disabilities. One program teaches parents how to advocate for their child's health, while the other connects them with other parents for shared learning. Researc…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study tests whether putting health warnings on alcohol containers can reduce drinking. 720 adults who drink at least once a week will bring their own alcohol to study visits, where labels warning about cancer, high blood pressure, and liver scarring will be added to some bot…

This study aimed to see if a hands-on knee joint manipulation could improve thinking and movement in people who had ACL reconstruction. It planned to enroll 30 adults aged 18-35 who were 4 months to 10 years past surgery. However, the study was withdrawn before any participants w…

This study follows 250 former NFL players and healthy volunteers aged 50-70 over 5 years. Researchers use brain scans, blood tests, and thinking/memory assessments to understand how concussions and repeated head impacts affect long-term brain health. The goal is to gather informa…

This study looks at how electrical stimulation of the brain affects working memory in 50 people with epilepsy who already have electrodes implanted. Participants perform a memory task while receiving different types of stimulation. The goal is to understand brain rhythms and impr…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study looks at whether encouraging young adults (ages 18-29) to have more in-person conversations with people they don't know well can help reduce feelings of loneliness and social isolation. About 1,900 participants will use a smartphone app to track their location and answ…

This study was designed to test whether giving small electrical pulses directly to the brain could improve working memory in people with epilepsy. Researchers planned to use electrodes already placed in the brain for epilepsy surgery. However, the study was withdrawn before any p…

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical details and biological samples to learn why preterm births happen, with the goal of finding new ways to prevent them. No treatment is given—this is an …

This study aims to understand how drugs like cocaine, alcohol, marijuana, and cigarettes taken during pregnancy affect the way mothers and babies bond. Researchers will look at the baby's brain and behavior shortly after birth. The study involves 150 mothers and their newborns.

This study looks at how breathing in low levels of ozone—similar to what you might encounter on a typical day in Chapel Hill—affects lung function and airway inflammation in adults with mild asthma. Researchers will compare ozone exposure to filtered air in 18 participants. The g…

This study follows 210 people who had a complex or conversion hip replacement more than 5–10 years ago. Researchers want to see how well the hip is working now by using surveys about pain and daily activities, plus X-rays. The goal is to understand long-term outcomes and what aff…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…

This study tests a program to help prenatal clinics improve how they measure and treat high blood pressure in pregnant and postpartum patients. About 4,000 clinic staff from North Carolina will receive training, coaching, and practice sessions. Researchers will check if the progr…

This study aims to understand how nontuberculous mycobacteria (NTM) spread among people with cystic fibrosis (CF). NTM infections are hard to treat and common in CF, but their sources are unclear. Researchers will track 100 participants with CF and NTM, testing dust and water in …

This study looks at genes, other than the CF gene, that might explain why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants with CF who have serious liver problems. …

This study examines how different genes influence the severity of lung disease in people with cystic fibrosis. Researchers will analyze genetic data from 600 participants to identify gene variants linked to milder or more severe lung problems. The goal is to better understand the…