University Of North Carolina, Chapel Hill

This study is testing whether a diet that eliminates specific foods identified by a person's immune system tests works better than a fake diet to control Eosinophilic Esophagitis (EoE). One hundred participants, aged 16-80 with active EoE, will be randomly assigned to follow eith…

This early-stage study is testing whether a patient's own lung stem cells, grown from a small biopsy and given through an IV, can safely slow the progression of idiopathic pulmonary fibrosis—a serious lung-scarring disease. The trial involves 24 patients with progressive lung fib…

This study is testing whether a brief counseling program can help people who are starting or restarting HIV prevention medication (PrEP) to continue taking it properly while also reducing heavy drinking. Researchers will compare the counseling program to standard care in 562 part…

This study is testing how well an already FDA-approved drug, dupilumab, works for people with a severe form of Eosinophilic Esophagitis (EoE) that causes dangerous narrowing of the esophagus. All 30 participants will receive weekly dupilumab injections under the skin for one year…

This study is testing whether anifrolumab, an existing immune-system drug, can help control hidradenitis suppurativa (HS), a chronic inflammatory skin condition. Fifteen adults with moderate-to-severe HS will receive the drug intravenously over 24 weeks, followed by monitoring. R…

This study is testing a device that freezes and destroys abnormal cells in the esophagus (a condition called Barrett's esophagus) in patients where standard heat-based treatments have not worked well. About 70 participants will have the freezing treatment every few months for up …

This study is testing if the drug baricitinib can help control moderate to severe oral lichen planus, a chronic inflammatory condition that causes painful sores in the mouth. It involves 10 adults who have not improved with other treatments. Participants will take the drug for si…

This study tests if delivering medically tailored meals helps adults with type 2 diabetes who struggle to afford healthy food. Researchers will compare 200 participants: half receive weekly healthy meal deliveries and coaching for 6 months, while the other half receive a small mo…

This study is testing a new program called 'Forging New Paths' for adults with serious mental illness who have had contact with the criminal justice system. The program aims to reduce aggressive behavior and help people stay in their communities by targeting specific risk factors…

This study tests a training program called ACHIEVE that helps prenatal care clinics improve how they handle high blood pressure in pregnant and postpartum patients. The program provides coaching, simulations, and educational materials to clinic staff across 20 clinics in North Ca…

This study is testing how well a heart health education program works when run by local community members. It involves about 210 Black adults living in rural eastern North Carolina who have risk factors for heart disease. The main goal is to see if the program helps lower partici…

This study is testing whether regular text message check-ins and direct messaging with a medical team helps people with Crohn's disease or ulcerative colitis feel more confident managing their condition and achieve better health outcomes. It will involve 900 teenagers and adults …

This study is testing two different ways to train HIV clinic staff in Vietnam to deliver a brief alcohol counseling program to their patients. The goal is to see which training method helps clinics do a better job of offering this counseling, which aims to reduce unhealthy drinki…

This study aims to find the best way to prevent suicide among autistic youth, who face much higher suicide risk than their peers. Researchers are comparing two specially designed safety planning approaches for 12-24 year olds: a basic safety plan versus that same plan with regula…

This study is testing whether teachers in rural Indian primary schools can be trained to provide mental health support to children showing signs of behavioral or emotional difficulties. Over 20,000 participants across 90 schools will be involved, with some schools receiving speci…

This study is testing whether taking omega-3 fish oil supplements for 12 weeks can help reduce migraine pain and improve quality of life for children and teenagers aged 10-17. Researchers are comparing the supplement to a placebo (a dummy pill) in 58 participants to see if it low…

This study compares two different approaches to help parents of youth with intellectual and developmental disabilities become better advocates for their children's healthcare. Researchers are testing whether a structured advocacy skills curriculum or peer-led learning groups work…

This study aimed to find the best spinal pain medication for women with opioid use disorder who are taking buprenorphine and have a cesarean section. It planned to compare two different pain drugs given during the spinal block to see which provided better pain control after surge…

This study is exploring whether looking at specific colors of light can help reduce chronic pain. Researchers are testing the approach in 60 adults with fibromyalgia or chronic low back pain. The main goal is to see if the light therapy is practical to use and to understand how i…

This study aims to understand why preterm births and stillbirths happen in Zambia. Researchers will follow 9,000 pregnant women and their babies for a year after birth, collecting health information and biological samples. The goal is to discover the underlying causes to help dev…

This study aims to understand how people with cystic fibrosis (CF) catch hard-to-treat NTM lung infections. Researchers will follow 100 people with CF from six care centers to see if infections spread between patients in healthcare settings or come from shared water sources. The …

This study aimed to understand if gentle electrical stimulation, delivered through electrodes already placed in the brain for epilepsy surgery planning, could improve a person's working memory. It planned to test this in adults with drug-resistant epilepsy. The goal was to gather…

This study aims to understand how a mother's use of substances like cocaine, alcohol, marijuana, or cigarettes during pregnancy might affect her bond with her baby and the baby's early brain development. Researchers are inviting mothers who have or have not used these substances …

This study aims to understand why some people with cystic fibrosis develop serious liver disease while others do not. Researchers are looking at genes other than the main CF gene that might influence this risk. They are analyzing blood samples and medical information from about 1…

This study aims to understand why lung disease varies so much in people with cystic fibrosis (CF), even when they have the same genetic mutation. Researchers are analyzing the DNA of 600 CF patients to identify other genes that might make the lung disease milder or more severe. T…

This study aims to collect information on how osteoarthritis patients feel after receiving standard low-dose radiation therapy for joint pain. Researchers will follow 40 patients to track their pain levels, joint function, and quality of life over time. The goal is to better unde…

This study aims to understand how breathing low levels of ozone, similar to a typical summer day, affects lung function and causes inflammation in adults with mild asthma. Participants with mild asthma will be exposed to clean air and low-level ozone on separate occasions while d…

This study follows people who had complex hip replacement surgeries 5-10+ years ago to see how they're doing long-term. Researchers are checking pain levels, physical function, and hip health through surveys and X-rays. The goal is to understand what happens to patients many year…

This is a long-term observational study, not a treatment trial. Its purpose is to learn more about Chronic Obstructive Pulmonary Disease (COPD) by following a large group of people over many years. Researchers are observing participants to identify different types of COPD, find b…

The Keep Social randomized control trial (RCT) is a 6-week, online study which will test whether, relative to a placebo control condition, an intervention that encourages high-quality in-person social interactions with strangers and acquaintances reduces young adults' (ages 18 - …