University Of North Carolina, Chapel Hill

This study tests whether baricitinib, a drug that calms the immune system, can help people with moderate to severe oral lichen planus—a painful, long-lasting mouth condition. Ten adults who have not responded to other treatments will take the drug for six months. Researchers will…

This early-phase trial tests whether a person's own lung stem cells, grown from a small biopsy and given through an IV, are safe for treating idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. About 24 adults aged 40-80 with IPF wil…

This study tests whether a brief alcohol intervention (a few counseling sessions) helps people who drink heavily stay on PrEP, the daily pill that prevents HIV. About 562 adults in Hanoi who are starting or restarting PrEP will either get the alcohol counseling or standard care. …

This study looks at how well dupilumab, an FDA-approved drug, works for people with severe eosinophilic esophagitis (EoE) and narrowed food pipes. About 23 participants will receive weekly injections for one year. The goal is to reduce inflammation and improve swallowing, with re…

This study tests a program called Forging New Paths for adults with serious mental illness who have been involved with the criminal justice system. About 72 participants will either receive the program plus usual care or usual care alone. Researchers will measure changes in aggre…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus in people who still have abnormal cells after several standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing treatment. The goal is to see if it c…

This study tests whether anifrolumab, a drug that blocks certain immune processes, can help people with hidradenitis suppurativa (HS) — a painful skin condition causing boils and tunnels. About 15 adults with moderate-to-severe HS will receive the drug intravenously over 24 weeks…

This study looks at how to best roll out a brief alcohol counseling program (BAI) in HIV clinics across Vietnam. The goal is to reduce unhealthy drinking, which can lead to risky behaviors and HIV spread. Over 3,200 people living with HIV and clinic staff are taking part. One gro…

This study tests a program called Thriving Hearts that helps pregnant people and new mothers in 10 North Carolina counties. The program provides support at the individual, healthcare provider, and community level to reduce high blood pressure disorders during pregnancy. About 17,…

This study tests a mobile health program designed to help young U.S. Air Force personnel prevent weight gain over two years. About 350 active-duty members aged 18-39 with a BMI between 21 and 30 will use a smartphone app and a Fitbit tracker. The goal is to see if this approach c…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults with treatment-resistant depression will receive one or two psilocybin sessions a…

This study looks at whether omega-3 supplements (like fish oil) can help reduce migraine pain and improve daily life in children and teens aged 10 to 17. Over 12 weeks, researchers will measure changes in blood omega-3 levels and track pain intensity. The goal is to find a simple…

This study tests whether a 2-minute perineal massage before a pessary check can reduce pain and improve comfort. About 68 women with prolapse or stress incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, drug-free way to make…

This study looks at how well a group program for chronic pain works in health centers that serve low-income patients. The program combines medical advice, gentle movement, and mind-body techniques. Researchers will train clinic staff and track how many patients join, how much it …

This study aimed to compare two pain medicines given during spinal anesthesia for cesarean delivery in patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery over 36 hours. However, the study was wi…

This study tests whether adding low, horizontal and vertical lights around bathroom and entry doorframes can help reduce nighttime falls in people with Alzheimer's or related dementias. About 335 assisted living residents with dementia will take part, with each person experiencin…

This study tests if special colored light shown to the eyes can lower pain in people with chronic low back pain or fibromyalgia. Sixty adults will wear a light device for 2 hours daily over 5 days. The goal is to see if this light therapy is feasible and reduces pain intensity.

This study follows 40 adults aged 55 and older with osteoarthritis who are receiving low-dose radiation therapy as part of their usual care. Researchers will track changes in pain, physical function, and quality of life over one year to see if this treatment helps ease symptoms. …

This study follows 210 adults who had a complex or conversion hip replacement more than 5–10 years ago. Researchers review medical records and clinic visits to measure pain, physical function, and hip health using surveys and X-rays. The goal is to understand how well these patie…

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. The goal is to see which program better reduces suicidal thoughts and behaviors. Researchers will track participants for one year to measure effectiveness.

This study follows 770 people who have had a type of stent-graft repair for aortic aneurysms in the chest or belly. The main goal is to see how well the kidneys and other organs work over two years after the procedure. Researchers will use scans and blood tests to gather informat…

This study looks at how breathing in low levels of ozone (a common air pollutant) affects lung function and airway inflammation in adults with mild asthma. Researchers will compare the effects of ozone versus clean air on 18 participants aged 18 to 45. The goal is to understand h…

This study explores why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants to find "modifier genes" that might influence liver health. The goal is to better understan…

This study tests whether an artificial intelligence (AI) tool can help outpatient doctors reduce the time they spend reviewing medical records and doing paperwork. About 150 doctors will be randomly assigned to either use the AI tool right away or continue their usual routine for…

This study aimed to see if moving and manipulating the knee joint could improve how quickly the brain and muscles react in people who had ACL surgery. Researchers planned to test 30 adults aged 18-35 who were 4 months to 10 years past their surgery. The study was withdrawn before…

This study aimed to see if rhythmic electrical stimulation of the brain could improve working memory in people with drug-resistant epilepsy. Researchers planned to test this in patients already undergoing brain surgery monitoring. However, the study was withdrawn before any volun…

This study looks at how using drugs like cocaine, alcohol, marijuana, or cigarettes during pregnancy may affect the way mothers and babies bond. Researchers will study the baby's brain and behavior to understand these effects. The study involves 150 mothers and their newborns.

This study looks at how mild electrical stimulation to certain brain areas changes working memory in 50 adults with epilepsy who already have electrodes implanted for monitoring. Participants do a memory task while receiving short bursts of stimulation. The goal is to learn which…

This study tests whether a mobile health tool used by community health workers can improve follow-up care for women who had a c-section in rural Rwanda. About 1,350 women will be randomly assigned to either home visits using the tool or standard clinic follow-up. The goal is to s…

This study compares two programs for parents of teens and young adults (ages 11-27) with intellectual or developmental disabilities. One program teaches advocacy skills, the other connects parents with peers for shared learning. Researchers will measure changes in parent confiden…

This study looks at whether training and coaching for clinic staff can improve how they measure blood pressure and educate patients about hypertension during and after pregnancy. About 4,000 providers and staff from prenatal clinics in North Carolina will take part. The goal is t…

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical details and biological samples to learn why some babies are born too early. The goal is to find new ways to prevent preterm birth and stillbirth.

This study looks at how different genes can make cystic fibrosis lung disease better or worse in different people. Researchers are studying 600 people with CF to find genetic clues that explain why some have milder lung problems. The goal is to learn more, not to test a new treat…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study follows nearly 3,000 people with COPD (a lung disease) and some healthy smokers and non-smokers over several years. Researchers are collecting health data, lung function tests, and imaging to find patterns in how COPD progresses and to develop better ways to measure th…

This study aims to find out how nontuberculous mycobacteria (NTM) — a hard-to-treat lung infection — spreads among people with cystic fibrosis (CF). Researchers will collect dust and water samples from clinics and patients' homes, and map water sources to see if they match the NT…

This study follows 250 former NFL players (ages 50–70) for 5 years to see how concussions and repeated head hits affect long-term brain health. Researchers use brain scans, blood tests, and thinking/mood questionnaires to track changes. The goal is to use these findings to design…