University Of North Carolina, Chapel Hill

This study tests a new approach to address the youth mental health crisis in rural India by training teachers to provide mental health support to their students. Teachers in 60 low-cost private schools will learn to weave evidence-based therapeutic techniques into their daily int…

This study is testing a community support program called CommunityRx-Kidney Health (CRx-K) for people with chronic kidney disease (CKD) living in rural North Carolina. The program provides patients with education, a personalized list of local health and social resources (like foo…

This study is testing if virtual family support sessions can help rural families in North Carolina get their young child (under age 4) into autism therapy faster after a diagnosis. It will compare families who receive four virtual coaching sessions with a trained guide to familie…

This study aims to find the most effective telehealth approach to help older adults with obesity and multiple chronic conditions lose weight. Researchers will test two different weight loss programs—one focused on medical guidance and one focused on behavior coaching—and adjust t…

This study is testing if a program that provides healthy food vouchers works better when paired with a continuous glucose monitor (CGM) and nutrition counseling. It will involve 60 adults with type 2 diabetes who also struggle to afford or access healthy food. The goal is to see …

This study is testing whether the medication mirikizumab can help control chronic inflammation in the pouch created after colon removal surgery for ulcerative colitis. Twenty-five adults with ongoing pouch problems will receive monthly injections for one year while tracking their…

This study is testing a new telehealth program called REAL-Fam to see if it's practical to study on a larger scale. It aims to help rural families better manage their child's type 1 diabetes by improving daily routines, family teamwork, and quality of life. Researchers will compa…

This study is testing a new device called LOBO™ to block abnormal connections between arteries and veins in the lungs. Researchers want to see how well the plug works to close these vessels and if it stays closed over 3 years, compared to older methods. About 30 people with these…

This study is testing a short counseling program called Treat4All, designed to help people reduce heavy alcohol use. It aims to see if this helps people better manage their HIV treatment if they have the virus, or start and stay on preventive medication (PrEP) if they are at high…

This early-stage study is testing the safety of two new antibody drugs, MGD014 and MGD020, in people with HIV who are on stable treatment. Researchers want to see if adding a pill (Vorinostat) that helps expose hidden HIV in the body, or temporarily stopping standard treatment, m…

This study aims to find the best caffeine dose for newborns who experienced oxygen deprivation at birth, which can cause brain injury. Researchers will test caffeine in 16 infants who are already receiving cooling therapy to protect their brains. The main goal is to determine saf…

This study is testing whether a personalized, active rehabilitation program can help soldiers with mild traumatic brain injuries (concussions) recover faster and more completely. The program provides guided physical and mental activities that start soon after injury and adjust ba…

This study is observing how well the medication Zymfentra works for people with Crohn's disease or ulcerative colitis in real-world settings. About 200 adult patients who are already prescribed Zymfentra as part of their regular care will complete online surveys about their sympt…

This study is testing if a program that delivers healthy, doctor-approved meals and provides lifestyle coaching is better than just receiving meals alone. It aims to help adults with HIV who also have type 2 diabetes or are at high risk for it, and who struggle to afford enough h…

This study aims to see if providing free healthy prepared meals and nutrition education improves people's diets more than just getting exercise coaching. It involves 120 adults from Anson County, NC, who have or are at risk for chronic conditions like diabetes or heart disease. P…

This study is testing a new type of PET/MRI scan to see if it can better detect endometriosis, a painful condition where tissue similar to the uterine lining grows outside the uterus. Researchers will enroll 24 women who have symptoms and are scheduled for surgery to see how accu…

This study is testing a new community-based care model to prevent HIV from passing from mothers to their babies in Malawi. Mobile health teams will bring faster infant testing and treatment services directly to families in their communities, aiming to reach those who struggle to …

This study is testing a 2-year mobile health program designed to help young, active-duty Air Force personnel prevent weight gain. It will enroll 350 participants who will use a smartphone app and a Fitbit activity tracker to receive guidance on diet and exercise. The goal is to p…

This study is testing a new 90-day support program called 'Caring Connections' designed to prevent suicide in teenagers and young adults who are at high risk. The program connects youth with community resources, helps create safety plans, and provides follow-up support through lo…

This study is testing whether combining job opportunity information with HIV prevention education helps young adults in Baltimore improve their financial stability and reduce their risk of getting HIV. About 500 young adults, aged 18-24, who are facing economic hardship and are s…

This study is testing a 90-day support program called 'Caring Connections' designed to prevent suicide in high-risk teenagers. The program connects teens with mental health services, helps create safety plans, and builds a network of community support, often through faith-based o…

This study is testing a new support program for people with Alzheimer's or dementia and their caregivers during the transition from a nursing facility to home or another care setting. The program provides extra help and education to nursing facility staff and assigns a specialist…

This study is testing whether a very brief technique called iCOVER can help people who are experiencing an acute stress reaction. The technique takes 60-120 seconds and involves simple steps like making eye contact, asking factual questions, and helping the person re-engage in pu…

This study is testing two different remote support programs for child care center staff to see which one better improves their mental well-being and resilience to stress. About 640 staff members from 80 centers will be randomly assigned to either a resilience-building program or …

This study is testing a 5-week program that combines mindfulness meditation and graded exposure exercises, delivered through an app, to help people who have had ACL knee surgery. The goal is to see if the program can reduce patients' fear of getting hurt again and improve their p…

This study is testing whether a special 3-day program called Alliance180, which includes time with horses, can improve mental and physical well-being. It is for U.S. veterans, first responders, and frontline healthcare workers who are dealing with stress or trauma. Researchers wi…

This study is testing whether specific walking training using metronomes can improve how people with Parkinson's disease walk. Participants will complete 12 training sessions using slow and fast metronome beats on a treadmill and overground walking. Researchers will measure walki…

This small pilot study is testing whether a mindful running program, guided by the Headspace app, is practical and helpful for adults with chronic kneecap pain. Researchers want to see if combining mindfulness with running can reduce pain, lessen fear of movement, and improve run…

This study is testing whether a simple numbing injection given around the cervix during vaginal hysterectomy surgery helps patients use fewer strong opioid painkillers afterward. Researchers will compare 56 patients who receive the numbing medicine to those who receive a placebo …

This is a small, early-stage study to see if a personalized, non-invasive brain stimulation technique is safe and tolerable for pregnant women with depression. Researchers will test the approach on 10 participants—five healthy women and five with antenatal depression—to check for…

This study is testing a new virtual reality (VR) tool designed to help teenagers who are hospitalized for suicidal thoughts or behaviors. The VR program creates realistic school and social situations where teens can safely practice coping skills with a therapist's guidance while …

This study is testing whether a specific type of nerve block, designed to spare a breathing muscle, can lower the risk of early breathing problems after shoulder surgery in adults with obesity. Researchers will compare this new approach to the standard nerve block to see if it re…

This study aims to find the best way to control pain after surgery for a broken wrist. Researchers are comparing two different numbing injections given near the shoulder to block pain signals. They want to see if a newer, longer-lasting version helps people recover better and nee…

This study is testing a mobile app designed to support caregivers of young adults experiencing early psychosis. The goal is to see if the app is practical to deliver and if it helps reduce caregiver stress and improve family communication. The pilot will involve about 30 caregive…

This study is testing a new therapy program designed to help caregivers and family members of people who have experienced psychosis. It aims to see if the program is practical and acceptable, and if it can improve caregivers' feelings of stress, loneliness, and overall well-being…

This study aims to find out which of two common talk therapies works better for autistic adults struggling with depression or anxiety. Researchers will compare Cognitive-Behavioral Therapy (CBT) and Mindfulness-Based Therapy (MBT), both delivered online, in 300 adults from North …

This study is testing a 16-week physical activity program called PACE for adults with intellectual disabilities. The program includes weekly group fitness classes, coaching sessions, and online resources. Researchers want to see if it helps participants become more active, improv…

This study is testing different ways to deliver physical therapy in the Neonatal Intensive Care Unit (NICU) to see which method works best. It aims to help parents feel less stressed and more confident in caring for their very premature babies, while also supporting the infants' …

This study aims to see if using hormone patches and pills can help women whose depression gets worse before their period. Researchers will test if stabilizing hormone levels during this time improves mood and the brain's ability to feel pleasure. About 75 women will try the hormo…

This study is testing two different online group therapy programs to help reduce the emotional distress that often comes with managing type 1 diabetes. Researchers will enroll 200 adults with type 1 diabetes who report significant distress. If the initial group program doesn't wo…

This study is testing an improved version of a non-surgical, FDA-approved ultrasound treatment for essential tremor, a condition that causes uncontrollable shaking. Researchers are using advanced 3D brain mapping to more precisely target and destroy the tiny brain area causing th…

This study is testing whether a specific parenting program can reduce stress levels in young children who have faced difficult life circumstances. About 150 caregivers and their toddlers will be randomly assigned to either receive the 10-session program right away or be placed on…

This study is testing whether putting warning labels on sugary drinks changes what people buy. About 543 adults who drink sugary beverages will shop in a mock store with either warning labels or regular labels over four visits. Researchers will track their purchases and survey th…

This study aims to understand if stimulating the brain with magnets can improve communication between the brain and weakened muscles after a stroke. Researchers will test 20 people who had a stroke at least 6 months ago. During a single 3-hour visit, participants will perform han…

This study aims to see if brief, simple tests measuring muscle strength, breathing, walking, and memory can predict which older adults (age 65+) are more likely to have complications after major abdominal surgery. Researchers will perform these tests during routine pre-surgery vi…

This study aims to understand if a therapist's and a client's brain activity sync up during a therapy session for depression. Researchers will measure brain waves in 45 students with mild to moderate depression and their therapists during a single session of either behavioral act…

This study aims to understand how light might help relieve pain by looking at brain activity. Researchers will use MRI scans to see how different colored lights affect brain connections and responses to pain in 30 people with chronic musculoskeletal pain and 30 healthy volunteers…

This study is testing a new type of MRI scan that uses a safe, inert gas to take pictures of how air moves in children's lungs. Researchers want to see if this scan can detect very early lung changes in kids with cystic fibrosis who otherwise seem healthy on standard breathing te…

This study is testing whether a daily omega-3 supplement called SPM Active® can increase certain beneficial compounds in the blood and improve feelings of burnout, life satisfaction, and sleep quality in adults with obesity. Researchers will enroll 33 adults aged 45-60 to take th…

This study aims to find out if wearing clear aligners for orthodontic treatment increases the amount of tiny plastic particles (microplastics) in a person's body. Researchers will follow 150 patients receiving clear aligner treatment, collecting their saliva and urine samples bef…

This study is testing whether putting new health warning labels on alcohol bottles changes how much people drink. Researchers will enroll about 720 adults who drink alcohol at least once a week. Participants will be randomly assigned to receive either warning labels or regular la…

This study aims to understand why women going through menopause who experience depression may have a higher risk of developing heart disease. Researchers will enroll 30 women to measure their body's stress responses during a brief social stress test. The goal is to gather knowled…

This study aims to better understand how lung function changes over time in adults with cystic fibrosis. Researchers will use a special MRI technique that involves breathing in a safe contrast gas to create detailed pictures of how air moves through the lungs. Participants will h…

This study is testing new wearable sensors that stick to the skin to measure vital signs like heart rate and breathing. Researchers want to see if these sensors are comfortable, safe, and work as well as standard medical equipment. Healthy volunteers will wear the sensors during …

This study is exploring whether a specific knee joint manipulation can improve how quickly the brain and muscles work together in people who have had ACL reconstruction surgery. Researchers will enroll 30 adults aged 18-35 who are 4 months to 10 years post-surgery and have slower…

This study aims to understand why depression rates differ between teenage boys and girls during puberty. Researchers will use a smartphone app and hormone measurements to see how testosterone affects mood and brain activity in 60 adolescents. The goal is to learn more about the b…

This study aims to understand how emotions, stress, and the body's systems affect the way people with borderline personality disorder (BPD) make decisions. Researchers will compare about 106 adults with BPD to healthy volunteers. Participants will play decision-making games, unde…

This is a small, early-stage study to see if a nutritional supplement called beta-hydroxy-methylbutyrate (HMB) is practical and acceptable for older adults to use. Researchers will give the supplement to 25 people aged 65-85 with multiple chronic conditions for 12 weeks. The main…

This study aims to improve care for children with hypospadias, a birth condition affecting the penis, by helping their parents. Researchers are testing two different educational websites to see which one better prepares parents for discussions with their child's urologist. The st…

This study aims to understand why some people with alpha-gal syndrome get stomach pain, diarrhea, and nausea after eating red meat. Researchers will give 30 participants pork with and without the alpha-gal sugar in a blinded test to see which one triggers symptoms. They will coll…

This study aims to understand what sensations can be created using spinal cord stimulation and how changing the stimulation settings affects these feelings. Researchers are enrolling 10 adults who are already getting spinal cord implants for chronic pain treatment. The goal is to…

This study aims to understand how psychological stress increases inflammation in the body, which is a known risk factor for heart disease. Researchers will give 120 healthy young adults either a common beta-blocker drug (propranolol) or a placebo, then measure their brain activit…