University Of North Carolina, Chapel Hill

This study tested a program called Gender-affirming Abriendo Puertas for transgender women living with HIV in Santo Domingo. The program included individual counseling, peer support, and community activities to help participants stay on HIV medication and achieve viral suppressio…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested whether a personalized diet, based on a blood test that identifies food allergies, can help people with eosinophilic esophagitis (EoE). 56 participants were randomly assigned to either a personalized elimination diet or a sham diet. The goal was to see if the pe…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This study adapted a proven mouth care program for nursing homes to work in assisted living facilities for people with dementia. Nursing assistants were trained to provide daily mouth care and given supplies. The goal was to reduce harmful mouth bacteria that can lead to pneumoni…

This completed Phase 2 trial tested several different drugs in 950 people with severe asthma. The goal was to see which treatments improve lung function and control symptoms. Participants tried each treatment for 16 weeks, with breaks in between, to find the best match for their …

This study tested whether sildenafil, a drug used for high blood pressure in the lungs, is safe for premature infants at risk of bronchopulmonary dysplasia (BPD), a serious chronic lung disease. 109 babies born before 29 weeks and needing breathing support were given either silde…

This study tested whether a vaccine already approved for meningitis B (Bexsero) can also protect against gonorrhea infection. Healthy men aged 18–35 received either the meningitis vaccine or a placebo, then were exposed to the gonorrhea bacteria in a controlled setting. The goal …

This study tested whether sending specific motivational messages at just the right moment helps young adults with overweight or obesity meet their daily weight loss goals. Over 200 participants used a smartphone app with a weight loss program, and some received extra messages tar…

This study tested a two-week course of antibiotics (TMP/SMX or minocycline) given twice to people with cystic fibrosis who had early MRSA lung infections. The goal was to see if this approach could clear the bacteria better than standard care. The trial included 37 participants a…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested a culturally-tailored program called HARMONY for African American women at risk for heart disease, stroke, and diabetes. Over 8 sessions plus monthly boosters, participants learned stress management, exercise, and healthy eating. The goal was to see if the progr…

This study looked at whether adding an inhaled medication called Bronchitol (mannitol) can further improve mucus clearance in people with cystic fibrosis who have moderate to severe lung disease and are already taking a triple-combination drug (elexacaftor/tezacaftor/ivacaftor). …

This study tested a 24-week lifestyle program for unemployed adults receiving employment services. The program included online classes and one-on-one coaching on topics like healthy eating, stress management, and exercise. Researchers measured changes in weight, blood pressure, a…

This study tested whether an online family skills training program is practical and well-liked for Black adults trying to lose weight. 21 participants joined with a family member. The program focused on healthy eating and activity habits.

This study tested a new weight loss program called Med-South, which adapts the Mediterranean diet for Southern tastes, against the popular WW (Weight Watchers) program. Over 360 adults with obesity participated for 2 years, with researchers tracking weight loss, blood markers, an…

This study tested whether MRI can detect brown adipose tissue (brown fat) as accurately as PET scans, which use a radioactive tracer. Eight healthy adults had both scans under mild cold conditions. The goal is to see if MRI, which avoids radiation, could replace PET for brown fat…

This pilot study tested whether watching a culturally tailored telenovela (soap opera) online could help Latinas in North Carolina adopt HIV prevention behaviors like using condoms, getting tested, and learning about PrEP. 95 women participated, watching four 10-minute episodes o…

This pilot study tested whether giving vitamin D shortly after a burn injury could prevent chronic pain. Forty adults with burns took either vitamin D or a placebo and were followed for six months. Researchers also studied how vitamin D affects the immune system after a burn. The…

This study tested whether giving pregnant women with hepatitis B a daily pill (tenofovir) plus giving their newborns a hepatitis B vaccine at birth could safely prevent the virus from passing to the baby. The trial enrolled 317 women in the Democratic Republic of Congo and follow…

This study tested three different daily doses of the HIV prevention pill PrEP in 54 pregnant women in Sub-Saharan Africa. The goal was to find the dose that gives the best protection without harming the mother or baby. Researchers measured drug levels in the blood and tracked any…

This study tested a group prenatal care program called TLC for obese women at high risk for gestational diabetes. Over 300 women joined small groups led by a healthcare provider and learned about nutrition, exercise, and healthy habits. The goal was to see if this approach could …

This pilot study tested a counseling tool called MyChoice to help pregnant women in Malawi decide whether to use oral PrEP or condoms for HIV prevention. 100 HIV-negative pregnant women were randomly assigned to receive either the MyChoice shared decision-making intervention or s…

This study is testing a virtual reality (VR) program called PrESR for teens ages 13-18 who are hospitalized for suicidal thoughts or behaviors. The VR program lets them practice coping skills in simulated school and social situations with a therapist's guidance. The study will ch…

This pilot study tested whether a progressive outdoor mindful running program, guided by the Headspace app, is feasible and helpful for adults with patellofemoral pain (front knee pain). 18 participants completed a 5-week program that introduced mindfulness and guided mindful run…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This study tested whether a simple writing therapy, done over video calls, could help prevent or reduce PTSD in women who recently experienced sexual assault. Thirty women who visited a Sexual Assault Nurse Examiner (SANE) clinic within 7 days of the assault took part. The therap…

This study looked at whether high-intensity resistance training plus creatine supplements can improve muscle quality and thinking skills in perimenopausal women. Fifty-five healthy women aged 38-60 took part, with some getting creatine, some a placebo, and some no supplement. The…

This study tested whether giving teens with ADHD and their parents a question list or a short video before a doctor visit helps them talk more openly and get better care. About 126 English-speaking teens aged 11-17 with ADHD took part. The goal was to see if these tools improve s…

This study looked at whether women who had surgery for prolapse or incontinence could safely remove their urinary catheter at home one day after surgery, instead of waiting 3-4 days. 128 women who failed a voiding trial before leaving the hospital took part. The main goal was to …

This study tested a mobile health app designed to help young adults aged 18-25 reduce heavy drinking. 40 participants were randomly assigned to use the app or just complete surveys. Over 4 weeks, they received text message surveys to track drinking and engagement. The goal was to…

This study tested a moderated online platform called Altitudes for parents and caregivers of young people with psychosis. Seventeen caregivers used the site for six months, accessing educational content and connecting with peers. The goal was to see if the platform was easy to us…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support to reduce hospital transfers and improve symptom co…

This pilot study tested whether a care model called PREVAIL is practical and acceptable for adults with rheumatoid arthritis. The model includes a screening tool to identify activity limitations, a recommendation to the rheumatologist for exercise or physical therapy, and an onli…

This pilot study tested whether a dietary supplement containing fiber and green tea extract could increase feelings of fullness from alcohol in 64 at-risk drinkers. Participants took either the supplement or a placebo before drinking alcohol in a lab setting. The goal was to see …

This study looked at whether a regular stretching routine could improve heart health in pregnant women with obesity. 224 women were assigned to either a stretching program or usual care (moderate exercise). The researchers measured blood pressure and other heart-related markers f…

This pilot study tracks changes in a specific inflammatory marker (IL-1β) in the nasal passages of adolescents during an asthma attack. Researchers collect nasal fluid samples daily for five days during an attack and compare them to baseline samples taken when the participant is …

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This study tested whether an AI tool called Evidently could help outpatient doctors spend less time reviewing medical records and documenting care. 128 doctors from the University of North Carolina were randomly assigned to use the tool or continue their usual routine for eight w…

This study looked at whether a time-restricted eating plan (fasting for 16 hours, 2-3 days a week) is feasible and acceptable for older adults aged 65-80 who have mild cognitive impairment and obesity. 33 participants completed the 12-week program, working with a psychologist to …

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study looked at how the nasal immune system of people with COPD reacts to a live flu vaccine (FluMist). Researchers compared those who have frequent COPD flare-ups to those who do not, to see if differences in immune response or viral replication might explain the flare-ups.…

This study tested whether giving HIV self-test kits to HIV-negative pregnant women for their male partners would increase the number of men who get tested for HIV. Two hundred women in Malawi were split into two groups: one where partners got a clinic referral slip, and another w…

This study tested whether a mobile health app called LIVEBORN can help nurse midwives improve how they support newborns who have trouble breathing right after birth. Over 14,000 newborns and their nurses took part. The app gave either real-time guidance or a summary after the eve…

This study tested whether a special dashboard called AWARE helps ICU doctors and nurses make decisions faster and more accurately than using standard electronic health records. 113 healthcare providers participated in a randomized trial where they answered clinical questions usin…

This study tested a 12-week virtual education program for primary care providers in North Carolina to improve how they manage atrial fibrillation (AFib). 70 providers joined online sessions to learn about AFib care and EKG interpretation. Researchers measured changes in provider …

This study tested a six-session virtual education program called 'AF at Home' for adults with atrial fibrillation. Participants attended Zoom classes over three weeks to learn about self-monitoring and managing their condition. The goal was to see if the program improved quality …

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at how pregnancy changes the levels of the HIV drug doravirine in the blood. Seven pregnant women living with HIV took a single dose of doravirine during their second and third trimesters, and again after giving birth. The goal was to find the right dose for pre…

This study looked at whether offering special wellness visits at clinics, linked with primary schools, encourages teens to get tested for HIV and use contraception. About 1,500 students in their final year of primary school took part, and researchers followed them for two years. …

This study tested the safety and tolerability of two types of prebiotic powders (hGOS and GOS) compared to a placebo in 60 healthy adults over 4 weeks. Participants added the powder to drinks daily and reported any gut symptoms. Researchers also checked changes in gut bacteria an…

This study tested whether an educational session at a church could help Latino adults learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty Spanish-speaking participants watched videos and completed surveys. The goal was to understand barr…

This study looked at whether virtual coaching helps rural pharmacists better counsel patients who are hesitant about COVID-19 vaccines. Twenty pharmacies took part, first receiving standard training and then adding one-on-one video coaching. Researchers measured how well pharmaci…

This study looked at how two different hand muscles recover from muscle relaxants given during surgery. In 57 patients, researchers used EMG monitors to compare recovery in the thumb muscle versus the pinky muscle. The goal was to see if one muscle gives a better signal for when …

This study looked at whether it's possible to have firefighters train each other in a 6-week exercise program. 52 career firefighters from three local fire departments took part. The goal was to see if the program was easy to run and if firefighters would stick with it. The resul…

This completed study followed 105 children and adults with primary ciliary dyskinesia (PCD), a rare lung condition, to track how their breathing and quality of life change during respiratory flare-ups. Researchers measured lung function, symptoms, and daily impacts to gather info…

This study tested whether a pay-it-forward approach—where one person's donation covers testing for the next person—could increase gonorrhea and chlamydia testing among men in China. Over 1,200 men who had sex in the past year but hadn't been tested recently took part. The goal wa…

This study involved 40 women in early menopause who reported increased irritability. Researchers gave them either estrogen patches or placebo patches to see how their brains reacted to hormone changes. The goal was to understand the brain mechanisms behind mood swings, not to tes…

This study tested two strategies to improve how often people with type 2 diabetes are referred to and attend diabetes self-management education (DSMES) classes. Researchers gave providers alerts in the electronic health record and offered peer support to patients. The goal was to…

This study tested how rhythmic brain stimulation (TMS) affects memory and brain connectivity in 71 healthy adults aged 18-35. Participants performed a memory task while receiving timed pulses to the front and top of the brain. The goal was to see if changing brain wave patterns c…

This study tested whether video-based coaching helps surgeons improve their skills and patient outcomes for ventral hernia repair. 59 surgeons from a national quality network participated, comparing live coaching, video feedback, or no coaching. The goal was to see if reviewing t…

This study tested a new virtual reality program designed to help teenagers who were hospitalized for suicidal thoughts practice skills for returning to school. The program, called PrESR, lets teens experience realistic school scenarios with a therapist's guidance while still in t…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This study looked at whether providing medically tailored meals to an entire household, rather than just one person, and delivering them with a dedicated driver instead of a commercial shipper, can improve diet quality and reduce loneliness. 103 participants were enrolled. The go…

This study tested whether a supplement called recombinant bovine lactoferrin (rbLf) can help regulate iron levels, improve gut health, and boost exercise performance in healthy adults. About 110 active men and women took rbLf, regular lactoferrin from cow's milk, or a placebo dai…

This study looked at how high-intensity interval training (HIIT) and protein drinks affect metabolism in overweight women going through perimenopause. Researchers measured energy use and fat burning before and after exercise in 28 women. The goal was to understand how muscle and …

This study tested whether warning labels on foods containing non-nutritive sweeteners (like artificial sweeteners) help Chilean parents identify those products and choose healthier options for their children. Over 3,900 parents were shown different label designs and asked to pick…

This study tested whether adding a warning label that says a product is ultraprocessed changes how Chilean parents view and intend to buy these foods. Over 3,600 parents were shown similar products with or without the extra label. Researchers measured purchase intentions and whet…

This study looked at how well people with Primary Ciliary Dyskinesia (PCD) clear mucus from their lungs, based on which gene mutation they have. Researchers measured lung clearance in 27 participants, including healthy volunteers and PCD patients with different genetic mutations.…