New hope against superbug in cystic fibrosis: early antibiotic combo shows promise
NCT ID NCT03489629
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a two-week course of antibiotics (TMP/SMX or minocycline) given twice to people with cystic fibrosis who had early MRSA lung infections. The goal was to see if this approach could clear the bacteria better than standard care. The trial included 37 participants aged 2 to 45 and measured how many had negative MRSA cultures after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Trimethoprim Sulfamethoxazole (TMP/SMX) or Minocycline
What this could lead to
If successful, this approach could help clear MRSA infections earlier in people with cystic fibrosis, potentially reducing lung damage and hospital stays.
What could go wrong
This was a small, early-phase trial with only 37 participants. The results may not apply to everyone, and the antibiotics can have side effects like allergic reactions or stomach upset.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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N.C. Memorial Hospital and N.C. Children's Hospital
Chapel Hill, North Carolina, 27599, United States
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National Jewish Health
Denver, Colorado, 80206, United States
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St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Texas Children's Hospital, Baylor College of Medicine
Houston, Texas, 77030, United States
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University of Michigan Health System
Ann Arbor, Michigan, 48109, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Washington Medical Center and Seattle Children's
Seattle, Washington, 98195, United States