New hope against superbug in cystic fibrosis: early antibiotic combo shows promise

NCT ID NCT03489629

Completed Disease control Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a two-week course of antibiotics (TMP/SMX or minocycline) given twice to people with cystic fibrosis who had early MRSA lung infections. The goal was to see if this approach could clear the bacteria better than standard care. The trial included 37 participants aged 2 to 45 and measured how many had negative MRSA cultures after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trimethoprim Sulfamethoxazole (TMP/SMX) or Minocycline
What this could lead to: If successful, this approach could help clear MRSA infections earlier in people with cystic fibrosis, potentially reducing lung damage and hospital stays.
What could go wrong: This was a small, early-phase trial with only 37 participants. The results may not apply to everyone, and the antibiotics can have side effects like allergic reactions or stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Indiana University

Indianapolis, Indiana, 46202, United States
N.C. Memorial Hospital and N.C. Children's Hospital

Chapel Hill, North Carolina, 27599, United States
National Jewish Health

Denver, Colorado, 80206, United States
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Texas Children's Hospital, Baylor College of Medicine

Houston, Texas, 77030, United States
University of Michigan Health System

Ann Arbor, Michigan, 48109, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Washington Medical Center and Seattle Children's

Seattle, Washington, 98195, United States

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