Could a single antibiotic be enough for cystic fibrosis lung infections?
NCT ID NCT05548283
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study looks at people with cystic fibrosis who need intravenous antibiotics for a sudden worsening of lung symptoms (called a pulmonary exacerbation). It compares treatment with one type of antibiotic (beta-lactam) versus two types (beta-lactam plus an aminoglycoside like tobramycin). The goal is to see if using just one antibiotic works as well as two, which could mean fewer side effects and simpler treatment. The study involves 730 participants aged 6 and older and measures lung function and symptom improvement over several weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- beta-lactam antibiotic and aminoglycoside (tobramycin)
- What this could lead to
- If one antibiotic works as well as two, it could simplify treatment for cystic fibrosis lung flare-ups, reducing side effects and drug burden.
- What could go wrong
- This is a Phase 4 study, so the drugs are already approved, but it may find that two antibiotics are still needed for best outcomes. Side effects from aminoglycosides include kidney and hearing issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
Contact Email: •••••@•••••
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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Billings Clinic
RECRUITINGBillings, Montana, 59101, United States
Contact Email: •••••@•••••
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Boston Children's Hospital, Brigham & Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Email: •••••@•••••
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CHOC Children's Hospital
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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Children's Hospital Medical Center of Akron
RECRUITINGAkron, Ohio, 44308, United States
Contact Email: •••••@•••••
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Children's Hospital of New York
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Email: •••••@•••••
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Children's National Medical Center
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Email: •••••@•••••
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Cook Children's Medical Center
RECRUITINGFort Worth, Texas, 76104, United States
Contact Email: •••••@•••••
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact Email: •••••@•••••
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Dayton Children's Hospital
RECRUITINGDayton, Ohio, 45404, United States
Contact Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30327, United States
Contact Email: •••••@•••••
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Helen DeVos Children's Hospital
RECRUITINGGrand Rapids, Michigan, 49546, United States
Contact Email: •••••@•••••
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Indiana University Medical Center
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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Joe DiMaggio Children's Hospital
RECRUITINGHollywood, Florida, 33021, United States
Contact Email: •••••@•••••
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John Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Email: •••••@•••••
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Lenox Hill Hospital Cystic Fibrosis Center
RECRUITINGNew York, New York, 10003, United States
Contact Email: •••••@•••••
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Long Beach Memorial Medical Center
RECRUITINGLong Beach, California, 90806, United States
Contact Email: •••••@•••••
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Maine Medical Center
RECRUITINGPortland, Maine, 04102, United States
Contact Email: •••••@•••••
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Email: •••••@•••••
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Morristown Medical Center
RECRUITINGMorristown, New Jersey, 07960, United States
Contact Email: •••••@•••••
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
Contact Email: •••••@•••••
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Nemours Children's Clinic
RECRUITINGJacksonville, Florida, 32207, United States
Contact Email: •••••@•••••
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New York Medical College at Westchester Medical Center
RECRUITINGValhalla, New York, 10595, United States
Contact Email: •••••@•••••
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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OSF Saint Francis Medical Center
RECRUITINGPeoria, Illinois, 61637, United States
Contact Email: •••••@•••••
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Oklahoma Cystic Fibrosis Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Email: •••••@•••••
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Oregon Health Sciences University
RECRUITINGPortland, Oregon, 97239, United States
Contact Email: •••••@•••••
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Providence Medical Group, Cystic Fibrosis Clinic
RECRUITINGSpokane, Washington, 99204, United States
Contact Email: •••••@•••••
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Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44146, United States
Contact Email: •••••@•••••
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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Rutgers - Robert Wood Johnson Medical School
RECRUITINGNew Brunswick, New Jersey, 08903, United States
Contact Email: •••••@•••••
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SSM Health Cardinal Glennon Children's Hospital
RECRUITINGSt Louis, Missouri, 63104, United States
Contact Email: •••••@•••••
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Saint Luke's Cystic Fibrosis Center of Idaho
RECRUITINGBoise, Idaho, 83702, United States
Contact Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact Email: •••••@•••••
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The Children's Hospital Alabama, University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Email: •••••@•••••
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Toledo Children's Hospital
RECRUITINGToledo, Ohio, 43606, United States
Contact Email: •••••@•••••
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Tucson Cystic Fibrosis Center
RECRUITINGTucson, Arizona, 85724, United States
Contact Email: •••••@•••••
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University of Calgary Adult Cystic Fibrosis Clinic (Calgary, AB)
RECRUITINGCalgary, Alberta, T2N4N1, Canada
Contact Email: •••••@•••••
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University of California San Diego
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
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University of California at Davis Medical Center
RECRUITINGSacramento, California, 95817, United States
Contact Email: •••••@•••••
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 45267, United States
Contact Email: •••••@•••••
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University of Florida
RECRUITINGGainesville, Florida, 32610, United States
Contact Email: •••••@•••••
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
Contact Email: •••••@•••••
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact Email: •••••@•••••
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
Contact Email: •••••@•••••
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University of Massachusetts Memorial Health Care
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact Email: •••••@•••••
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Email: •••••@•••••
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University of Michigan, Michigan Medicine
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75390, United States
Contact Email: •••••@•••••
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University of Texas Southwestern / Children's Health
RECRUITINGDallas, Texas, 75207, United States
Contact Email: •••••@•••••
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University of Washington Medical Center
RECRUITINGSeattle, Washington, 98195, United States
Contact Email: •••••@•••••
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53792, United States
Contact Email: •••••@•••••
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Vanderbilt Children's Hospital
RECRUITINGNashville, Tennessee, 37232, United States
Contact Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23219, United States
Contact Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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West Virginia University - Morgantown
RECRUITINGMorgantown, West Virginia, 26507, United States
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a peer coach help young people take control of their chronic illness?
- Early use of powerful CF drugs may boost growth in young children
- Hands-On therapy may soothe cystic fibrosis pain without drugs
- Newborn screening study aims to catch rare diseases at birth
- Breath sniffing may reveal early clues to cystic fibrosis drug success
- Could a common laxative soothe gut inflammation in cystic fibrosis?