University Of North Carolina, Chapel Hill

This study aims to find out if giving medication once a day through a chest tube works just as well as giving it twice a day for serious infections around the lungs. Researchers will compare outcomes in 270 hospitalized adults who already have a chest tube draining infected fluid…

This study is testing a mobile phone tool to help community health workers provide better home check-ups for women after C-section surgery in rural Rwanda. The goal is to spot dangerous wound infections earlier, get women to care faster, and reduce health problems and financial h…

This study is testing whether a quick-dissolve film called BXCL501, given in the emergency room after a car accident, can reduce immediate stress reactions and prevent long-term PTSD symptoms. Researchers will enroll 100 adults who come to the ER within 24 hours of a car crash an…

This study is testing whether a liquid placed under the tongue (sublingual immunotherapy) can help children aged 1-11 become less sensitive to cashew nuts. Over 18 months, researchers will see if the treatment safely allows kids to tolerate small amounts of cashew without a serio…

This study aims to find the best surgical method for people in Tanzania who need a second eyelid surgery due to trachoma, a blinding eye disease. It will compare a newer technique (B-RAP) against the standard one (BLTR) in 1,000 patients whose first surgery failed. The goal is to…

This study aims to find out which newer medications work best and are safest for children with inflammatory bowel disease (IBD) when standard anti-TNF drugs have stopped working. It will follow about 1100 children and teens who are already starting one of these newer medications …

This small pilot study is testing if a brief, video-based sleep therapy can prevent PTSD and depression in people at high risk after a car accident. Researchers will enroll 20 adults who go to the emergency room after a crash and are sent home. The goal is to see if this approach…

This small pilot study in Uganda is testing a new idea to prevent malaria in pregnant women. Researchers will give anti-malaria medicine to all members of a pregnant woman's household to see if it creates a 'safe zone' around her. The goal is to see if this approach is practical …

This study is testing a personalized prenatal support program called PTBCARE+ to see if it can lower stress and reduce the risk of early delivery in pregnant people who are at high risk for having a preterm baby. Researchers will compare about 1,200 participants who receive the e…

This study is testing whether a special omega-3 dietary supplement can reduce chronic jaw pain and sensitivity in adults with temporomandibular disorder (TMD). One hundred participants will take either the supplement or a placebo pill daily for eight weeks while tracking their pa…

This small pilot study aims to prepare for future research comparing two common over-the-counter pain medications—ibuprofen and acetaminophen—for treating menstrual cramps in women with Crohn's disease. The study will enroll 24 women to test whether participants can follow the st…

This study aims to see if putting warning labels on sugary drinks changes people's attitudes about weight and obesity. About 543 adults who recently bought sugary drinks will visit a mock store four times. They will be randomly shown either regular labels or warning labels on dri…

This study aims to understand how a ban on menthol cigarettes, when paired with a quit-smoking ad campaign, affects what people buy and their attempts to quit. About 1,185 U.S. adults who currently smoke menthol cigarettes will shop in a simulated store and receive text message a…

This study aims to see if a special fortified porridge and a caregiver training program can improve early learning and brain development in young children in rural Guatemala. Researchers will follow 400 mother-child pairs, starting when the babies are 6 months old, until they tur…

This study is testing whether a 6-week virtual parenting program helps parents feel more confident and knowledgeable about raising their teenager and understanding teen mental health. Researchers will enroll 60 parents of 11-14 year olds and randomly assign half to take the progr…