University Of North Carolina, Chapel Hill

This trial tests whether tirzepatide (Zepbound) can reduce daily bowel frequency in adults with an ileal pouch-anal anastomosis (IPAA) who have chronic high bowel frequency despite standard anti-diarrheal therapy. Participants will be assigned to receive tirzepatide or standard c…

This study tests a 6-month digital program that combines appetite awareness training with behavioral weight loss techniques, delivered remotely via Zoom. It aims to help Black women with obesity who binge eat at least once a week relearn hunger cues and prevent weight gain. The t…

This study tests whether upadacitinib, a drug already used for other conditions, can help adults with eosinophilic esophagitis (EoE) who still have symptoms despite using topical steroids. Over 12 weeks, 52 participants will take either upadacitinib or a placebo, then all will re…

This study tests a treatment called sublingual immunotherapy (SLIT) for children ages 1-11 with cashew allergy. For 18 months, children receive daily drops under the tongue to see if they can safely eat more cashew without a reaction. The goal is to reduce allergy severity, not c…

This pilot study tests whether giving a malaria drug (dihydroartemisinin piperaquine) to household members of pregnant women can help prevent malaria in the mothers. About 300 participants in Uganda will receive either a single dose or monthly doses. The goal is to see if this ap…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This early-stage study will test if a brief, breath-focused therapy called Acceptance and Commitment Therapy (ACT) is practical and safe for adults with chronic cough. Researchers will enroll 30 people to see if they can stick with the program and find it helpful. The goal is to …

This study tests whether medications that calm mast cells (ketotifen and cromolyn) can safely reduce persistent symptoms like fatigue, pain, and brain fog in people who had a tick-borne illness. Fifty adults aged 21-65 will receive either one of these drugs or a standard antihist…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This study compares two types of food labels to see which one better helps Indonesian adults spot unhealthy products. Researchers will show 1,000 participants either a nutrient warning label or the Nutri-Level label and test their ability to identify foods high in sugar, salt, or…

This study looks at how exercise and a saltwater mist (hypertonic saline) affect mucus clearance in people with primary ciliary dyskinesia (PCD), a rare lung condition where tiny hairs in the airways don't work properly. Researchers will measure how fast the lungs clear inhaled p…

This study aims to find out which cannabis warning messages are most effective at raising awareness and changing perceptions. Researchers will show US adults (both users and non-users) seven different warning messages covering topics like dependence, cognitive function, and cardi…

This study looks at how packaging with warning labels and cartoon characters influences what Colombian teens aged 12 to 17 think about buying and eating ultraprocessed foods. About 1,960 teens will view different product images online and answer questions about how likely they ar…

This study tests whether a training program helps surgeons and hospital staff reduce the number of opioid painkillers they prescribe after surgery. About 40 healthcare workers and patient representatives from hospitals in North Carolina will take part. The goal is to see if the p…

This study looks at how natural hormone changes during the menstrual cycle may make some teenage girls more irritable or depressed, especially those at risk for suicide. Researchers will give 50 girls ages 12-16 either a birth control pill to keep hormones steady or a placebo for…

This study tests a 6-week virtual parenting program called AMP-CARE for parents of teens aged 11-14. It aims to see if the program improves parents' confidence and knowledge about teen mental health. 60 parents will be randomly assigned to take the program right away or later. Th…