Brain study reveals why menopause hormones trigger irritability in some women

NCT ID NCT05388656

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 24 times

Summary

This study looked at why some women in early menopause become irritable when their estrogen levels change. Forty healthy women aged 45-59 with moderate to severe irritability took either estrogen or a placebo for three weeks. Researchers measured their brain activity and mood to understand the link between hormones and irritability.

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Contacts and locations

Locations

  • Carolina Crossing B, Suite 1

    Chapel Hill, North Carolina, 27517, United States

Conditions

Explore the condition pages connected to this study.